ENSG00000059691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263985 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding protein_coding 28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 2.8906866 2.630611 2.7537779 0.3879855 0.66562850 0.06577001 0.10920833 0.08320000 0.10610000 0.02290000 0.830197219 0.005471848 FALSE TRUE
ENST00000503160 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding nonsense_mediated_decay 28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 5.4384021 7.877181 4.0602715 3.1515236 1.05490939 -0.95438475 0.18970417 0.22256667 0.15226667 -0.07030000 0.561925266 0.005471848 FALSE TRUE
ENST00000508611 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding protein_coding 28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 1.6343212 3.009566 1.8889056 0.5243358 0.51246650 -0.66917282 0.05932917 0.09650000 0.07083333 -0.02566667 0.699740468 0.005471848 FALSE FALSE
ENST00000510720 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding nonsense_mediated_decay 28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 0.5571729 2.547167 0.1532781 1.5653597 0.07672594 -3.96914308 0.01674167 0.06856667 0.00600000 -0.06256667 0.049393468 0.005471848 TRUE TRUE
ENST00000515812 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding protein_coding 28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 6.3716721 6.938682 5.8162374 0.8696287 0.13484261 -0.25417487 0.22690417 0.22350000 0.22120000 -0.00230000 1.000000000 0.005471848 FALSE TRUE
MSTRG.25611.5 ENSG00000059691 HEK293_OSMI2_2hA HEK293_TMG_2hB GATB protein_coding   28.13223 32.96942 26.33772 6.481062 0.8254116 -0.3238881 9.1591032 8.707657 10.2560636 1.8486807 0.23382690 0.23587076 0.32543750 0.26236667 0.38970000 0.12733333 0.005471848 0.005471848 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000059691 E001 10.7548521 0.0235119587 0.4430943716 0.584662368 4 151670504 151670837 334 - 1.119 1.018 -0.365
ENSG00000059691 E002 6.7671166 0.0026444101 0.5557079623 0.684533898 4 151670838 151670848 11 - 0.926 0.858 -0.258
ENSG00000059691 E003 7.7603315 0.0023108107 0.8907408025 0.934222457 4 151670849 151670857 9 - 0.946 0.933 -0.049
ENSG00000059691 E004 16.0413335 0.0011868597 0.2876463525 0.428160807 4 151670858 151670862 5 - 1.167 1.262 0.336
ENSG00000059691 E005 15.7600842 0.0011490663 0.0593945042 0.125604021 4 151670863 151670887 25 - 1.105 1.275 0.603
ENSG00000059691 E006 71.1207016 0.0004623554 0.0002850421 0.001319013 4 151670888 151670943 56 - 1.747 1.909 0.549
ENSG00000059691 E007 222.3506409 0.0059154570 0.0118177509 0.033098822 4 151670944 151671135 192 - 2.264 2.376 0.372
ENSG00000059691 E008 262.2482162 0.0081058752 0.0276456630 0.067305530 4 151671136 151671302 167 - 2.337 2.445 0.361
ENSG00000059691 E009 6.9214130 0.0234656124 0.6962555340 0.796669357 4 151672609 151672761 153 - 0.926 0.872 -0.204
ENSG00000059691 E010 192.0775437 0.0024685775 0.0013286465 0.005071079 4 151672762 151672896 135 - 2.203 2.318 0.386
ENSG00000059691 E011 13.8420949 0.0381682923 0.6027096855 0.723648117 4 151672897 151675888 2992 - 1.212 1.125 -0.308
ENSG00000059691 E012 161.0128320 0.0002183006 0.0077214567 0.023079215 4 151679813 151679891 79 - 2.154 2.233 0.264
ENSG00000059691 E013 1.0371971 0.1256083123 0.7278724072 0.820451240 4 151686908 151687083 176 - 0.337 0.260 -0.519
ENSG00000059691 E014 184.6040120 0.0002192539 0.0034244555 0.011510056 4 151688630 151688736 107 - 2.212 2.293 0.270
ENSG00000059691 E015 132.9344164 0.0002524519 0.6843451300 0.787338729 4 151688737 151688763 27 - 2.114 2.130 0.052
ENSG00000059691 E016 0.0000000       4 151691658 151691724 67 -      
ENSG00000059691 E017 168.7924591 0.0002301634 0.7144869364 0.810678733 4 151701329 151701395 67 - 2.217 2.230 0.041
ENSG00000059691 E018 178.5050193 0.0003102035 0.8420677119 0.901533203 4 151701396 151701456 61 - 2.245 2.253 0.025
ENSG00000059691 E019 147.5114435 0.0002589015 0.7369625312 0.827266827 4 151701457 151701518 62 - 2.172 2.164 -0.025
ENSG00000059691 E020 3.0762331 0.0132532977 0.0206372482 0.052823314 4 151703179 151703341 163 - 0.785 0.419 -1.646
ENSG00000059691 E021 9.2904774 0.0345755488 0.9594953364 0.978565421 4 151703342 151703850 509 - 1.000 0.988 -0.046
ENSG00000059691 E022 146.9760807 0.0002436340 0.1486072315 0.259775725 4 151703851 151703895 45 - 2.191 2.151 -0.132
ENSG00000059691 E023 149.7307176 0.0002441627 0.5922456330 0.714826443 4 151705185 151705229 45 - 2.183 2.171 -0.042
ENSG00000059691 E024 146.1409642 0.0002642019 0.6963689945 0.796735452 4 151705230 151705269 40 - 2.156 2.170 0.048
ENSG00000059691 E025 190.8475556 0.0002665990 0.1263275895 0.229034191 4 151707988 151708101 114 - 2.303 2.266 -0.123
ENSG00000059691 E026 169.9431798 0.0003122027 0.1123664963 0.208993939 4 151716009 151716131 123 - 2.256 2.215 -0.136
ENSG00000059691 E027 0.1451727 0.0441566524 0.3590962641   4 151716132 151716244 113 - 0.143 0.000 -11.076
ENSG00000059691 E028 192.7796809 0.0010807545 0.0017193305 0.006343298 4 151716876 151717001 126 - 2.336 2.242 -0.316
ENSG00000059691 E029 150.2608076 0.0060498646 0.0084993753 0.025036312 4 151717002 151717074 73 - 2.249 2.112 -0.460
ENSG00000059691 E030 0.0000000       4 151717075 151717331 257 -      
ENSG00000059691 E031 186.7917170 0.0042250392 0.0275954306 0.067205794 4 151719425 151719538 114 - 2.324 2.220 -0.345
ENSG00000059691 E032 0.3299976 0.0274424043 0.3184875192   4 151719539 151721945 2407 - 0.000 0.188 10.734
ENSG00000059691 E033 17.7099310 0.0341432664 0.1209763471 0.221331968 4 151721946 151722215 270 - 1.143 1.314 0.605
ENSG00000059691 E034 1.2511787 0.0108647759 0.0134017421 0.036849879 4 151722216 151724480 2265 - 0.000 0.461 12.543
ENSG00000059691 E035 227.4317346 0.0090890519 0.3156087932 0.458366341 4 151758772 151758922 151 - 2.391 2.314 -0.255
ENSG00000059691 E036 169.9510059 0.0043678476 0.0008113341 0.003299590 4 151760807 151761007 201 - 2.311 2.159 -0.505