ENSG00000059588

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000040877 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding protein_coding 25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 3.033445 3.4125519 3.5541060 0.20248352 0.5425759 0.0584678 0.13168750 0.15080000 0.1608667 0.01006667 0.9287393104 0.0002165263 FALSE TRUE
ENST00000462259 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding processed_transcript 25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 5.401253 3.3252618 4.1014594 0.58611078 0.3185363 0.3018506 0.20371250 0.15133333 0.1857667 0.03443333 0.7083765632 0.0002165263   FALSE
ENST00000496673 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding processed_transcript 25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 5.832449 8.7915868 3.1125973 2.51370765 0.4266927 -1.4950171 0.23353333 0.35806667 0.1413000 -0.21676667 0.0004388237 0.0002165263 TRUE FALSE
MSTRG.3306.11 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding   25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 1.315311 0.7902659 0.6663089 0.44168129 0.3966626 -0.2427971 0.05242083 0.04113333 0.0298000 -0.01133333 0.9790738252 0.0002165263 FALSE TRUE
MSTRG.3306.16 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding   25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 4.381964 3.3137020 3.8249806 0.42503231 0.1710507 0.2064283 0.17203750 0.14220000 0.1734333 0.03123333 0.3306625333 0.0002165263 TRUE TRUE
MSTRG.3306.23 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding   25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 1.356042 0.2272541 1.4918331 0.05259627 0.3369944 2.6622195 0.05205833 0.01030000 0.0673000 0.05700000 0.0002165263 0.0002165263 FALSE TRUE
MSTRG.3306.6 ENSG00000059588 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP1 protein_coding   25.23501 23.70696 22.07891 4.274731 0.2468671 -0.1025967 1.385654 0.2671844 3.2115730 0.26718443 0.6350476 3.5388472 0.05855417 0.00830000 0.1460333 0.13773333 0.0140854743 0.0002165263 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000059588 E001 0.000000       1 234391313 234391338 26 -      
ENSG00000059588 E002 1.876718 0.0078384617 2.355778e-03 8.326089e-03 1 234391339 234391377 39 - 0.115 0.651 3.514
ENSG00000059588 E003 9.712305 0.0062662224 1.082370e-02 3.074148e-02 1 234391378 234391409 32 - 0.869 1.162 1.082
ENSG00000059588 E004 108.285250 0.0162820582 1.864956e-11 3.715145e-10 1 234391410 234391597 188 - 1.710 2.220 1.714
ENSG00000059588 E005 165.872944 0.0065651683 6.037364e-12 1.302095e-10 1 234391598 234391745 148 - 2.012 2.363 1.172
ENSG00000059588 E006 191.552313 0.0031397801 1.495871e-10 2.561587e-09 1 234392416 234392552 137 - 2.142 2.394 0.841
ENSG00000059588 E007 1.987538 0.0072900578 4.548977e-01 5.954797e-01 1 234392553 234392724 172 - 0.402 0.536 0.680
ENSG00000059588 E008 197.411335 0.0002320958 1.159430e-16 4.942630e-15 1 234393362 234393476 115 - 2.171 2.397 0.754
ENSG00000059588 E009 114.552901 0.0002616146 1.620547e-10 2.759868e-09 1 234393477 234393486 10 - 1.935 2.163 0.762
ENSG00000059588 E010 279.667670 0.0019470638 1.087545e-08 1.331560e-07 1 234393646 234393837 192 - 2.349 2.529 0.599
ENSG00000059588 E011 0.816796 0.0144898368 5.802192e-01 7.049941e-01 1 234398178 234398381 204 - 0.206 0.310 0.779
ENSG00000059588 E012 174.349305 0.0002245888 1.398348e-06 1.124704e-05 1 234398382 234398553 172 - 2.167 2.311 0.479
ENSG00000059588 E013 1.034091 0.0116453624 6.608489e-02 1.368545e-01 1 234400251 234400323 73 - 0.451 0.130 -2.390
ENSG00000059588 E014 18.141057 0.0134797621 8.073401e-01 8.776102e-01 1 234400853 234400948 96 - 1.285 1.267 -0.061
ENSG00000059588 E015 127.931689 0.0091822533 6.192191e-03 1.912037e-02 1 234401181 234401262 82 - 2.016 2.186 0.567
ENSG00000059588 E016 2.232944 0.1947980952 7.390841e-01 8.288050e-01 1 234405312 234405480 169 - 0.450 0.545 0.460
ENSG00000059588 E017 175.095078 0.0013682019 2.271075e-07 2.154581e-06 1 234405903 234406099 197 - 2.149 2.326 0.591
ENSG00000059588 E018 159.108178 0.0354485359 1.510274e-01 2.630574e-01 1 234406100 234407955 1856 - 2.261 2.140 -0.404
ENSG00000059588 E019 22.010471 0.0028578862 6.130582e-06 4.278422e-05 1 234409357 234409573 217 - 1.506 1.163 -1.193
ENSG00000059588 E020 4.202026 0.0039065571 7.715803e-03 2.306486e-02 1 234410404 234410444 41 - 0.868 0.490 -1.612
ENSG00000059588 E021 71.987405 0.0021573774 7.999609e-08 8.278672e-07 1 234410445 234410531 87 - 1.714 1.982 0.901
ENSG00000059588 E022 97.040613 0.0004407902 5.314890e-04 2.277259e-03 1 234418084 234418233 150 - 1.921 2.061 0.468
ENSG00000059588 E023 97.108331 0.0003497851 8.505600e-01 9.072897e-01 1 234420702 234420812 111 - 1.987 2.008 0.070
ENSG00000059588 E024 0.000000       1 234420813 234420814 2 -      
ENSG00000059588 E025 107.527102 0.0009906009 1.359814e-02 3.730169e-02 1 234425673 234425793 121 - 2.078 2.002 -0.256
ENSG00000059588 E026 81.918021 0.0004197142 1.080075e-03 4.235411e-03 1 234427317 234427388 72 - 1.975 1.860 -0.388
ENSG00000059588 E027 120.626162 0.0079325208 2.761569e-01 4.155665e-01 1 234427576 234427766 191 - 2.112 2.058 -0.181
ENSG00000059588 E028 129.209407 0.0024526777 2.939086e-02 7.075431e-02 1 234429136 234429324 189 - 2.152 2.077 -0.251
ENSG00000059588 E029 117.458526 0.0002643558 8.464283e-03 2.494839e-02 1 234429416 234429555 140 - 2.111 2.038 -0.242
ENSG00000059588 E030 88.445806 0.0005085533 6.609061e-04 2.755671e-03 1 234429556 234429677 122 - 2.009 1.892 -0.392
ENSG00000059588 E031 113.015539 0.0005930856 1.429452e-04 7.162647e-04 1 234430087 234430301 215 - 2.115 1.996 -0.397
ENSG00000059588 E032 95.118745 0.0037381504 1.366478e-05 8.795706e-05 1 234433410 234433571 162 - 2.072 1.879 -0.649
ENSG00000059588 E033 82.046432 0.0003644134 1.723866e-12 4.060946e-11 1 234437275 234437372 98 - 2.039 1.772 -0.898
ENSG00000059588 E034 117.789013 0.0026595257 2.036970e-10 3.408992e-09 1 234446803 234446975 173 - 2.186 1.936 -0.839
ENSG00000059588 E035 86.033643 0.0008423354 2.912238e-11 5.621138e-10 1 234448480 234448576 97 - 2.054 1.799 -0.858
ENSG00000059588 E036 24.188449 0.0007739987 2.432734e-07 2.293591e-06 1 234448577 234448579 3 - 1.552 1.194 -1.246
ENSG00000059588 E037 93.995190 0.0003225252 2.746523e-16 1.120656e-14 1 234450428 234450566 139 - 2.107 1.815 -0.978
ENSG00000059588 E038 71.373933 0.0004181444 4.786053e-14 1.424962e-12 1 234457667 234457756 90 - 1.994 1.684 -1.045
ENSG00000059588 E039 58.583481 0.0025825788 1.663316e-09 2.366581e-08 1 234459230 234459326 97 - 1.905 1.598 -1.038
ENSG00000059588 E040 58.139466 0.0047161232 1.472785e-07 1.448148e-06 1 234460261 234460396 136 - 1.897 1.603 -0.996
ENSG00000059588 E041 46.829528 0.0054416131 1.013679e-03 4.005973e-03 1 234463837 234463934 98 - 1.769 1.574 -0.663
ENSG00000059588 E042 40.530809 0.0103238282 1.093630e-01 2.046231e-01 1 234465656 234465708 53 - 1.671 1.559 -0.381
ENSG00000059588 E043 1.917695 0.0829847876 9.532670e-01 9.747694e-01 1 234466738 234466876 139 - 0.451 0.443 -0.043
ENSG00000059588 E044 62.678339 0.0049888689 2.558448e-01 3.927830e-01 1 234467502 234467650 149 - 1.832 1.777 -0.185
ENSG00000059588 E045 52.130626 0.0124243703 7.239403e-02 1.473224e-01 1 234471188 234471257 70 - 1.786 1.661 -0.424
ENSG00000059588 E046 50.222393 0.0112987037 8.604281e-02 1.690560e-01 1 234472714 234472811 98 - 1.767 1.651 -0.392
ENSG00000059588 E047 2.945454 0.0354806356 6.396722e-01 7.530136e-01 1 234472812 234472883 72 - 0.536 0.619 0.378
ENSG00000059588 E048 76.847285 0.0125144275 2.335636e-11 4.582428e-10 1 234478173 234479179 1007 - 2.068 1.605 -1.565