ENSG00000058600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299853 ENSG00000058600 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3E protein_coding protein_coding 47.14178 45.89828 45.17236 1.64838 0.06671427 -0.02299473 24.232043 31.141054 20.166199 1.3715847 0.5889580 -0.6266266 0.51722500 0.67810000 0.44636667 -0.23173333 6.054750e-19 6.05475e-19 FALSE TRUE
ENST00000563024 ENSG00000058600 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3E protein_coding protein_coding 47.14178 45.89828 45.17236 1.64838 0.06671427 -0.02299473 5.553318 2.193867 6.867078 1.3251400 0.8957915 1.6417583 0.11435833 0.04623333 0.15206667 0.10583333 4.410626e-01 6.05475e-19 FALSE FALSE
ENST00000564061 ENSG00000058600 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3E protein_coding retained_intron 47.14178 45.89828 45.17236 1.64838 0.06671427 -0.02299473 2.645394 1.523163 2.671157 0.1565632 0.2502588 0.8063449 0.05754583 0.03343333 0.05916667 0.02573333 4.563237e-02 6.05475e-19 FALSE TRUE
ENST00000569787 ENSG00000058600 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3E protein_coding retained_intron 47.14178 45.89828 45.17236 1.64838 0.06671427 -0.02299473 7.446093 4.334188 8.904822 0.3635815 0.9689896 1.0371195 0.15427083 0.09516667 0.19706667 0.10190000 2.766234e-03 6.05475e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000058600 E001 0.0000000       16 22297232 22297374 143 +      
ENSG00000058600 E002 1.9071109 0.0155108982 8.158547e-01 8.834423e-01 16 22297375 22297408 34 + 0.415 0.456 0.219
ENSG00000058600 E003 2.0586264 0.0124327888 9.001211e-01 9.402634e-01 16 22297409 22297410 2 + 0.477 0.456 -0.104
ENSG00000058600 E004 6.3442116 0.0119244205 1.125119e-02 3.176465e-02 16 22297411 22297419 9 + 1.025 0.698 -1.267
ENSG00000058600 E005 12.4664298 0.0655408953 3.262260e-01 4.696678e-01 16 22297420 22297426 7 + 1.187 1.060 -0.458
ENSG00000058600 E006 14.7569983 0.0438692370 2.626696e-01 4.004600e-01 16 22297427 22297429 3 + 1.260 1.124 -0.481
ENSG00000058600 E007 16.6704257 0.0196084613 2.656754e-01 4.037398e-01 16 22297430 22297432 3 + 1.296 1.180 -0.408
ENSG00000058600 E008 18.1001883 0.0207674686 4.723075e-01 6.113413e-01 16 22297433 22297433 1 + 1.305 1.231 -0.258
ENSG00000058600 E009 40.5836915 0.0103605983 1.091985e-01 2.043617e-01 16 22297434 22297454 21 + 1.671 1.554 -0.399
ENSG00000058600 E010 107.4066263 0.0072108235 1.908642e-01 3.148310e-01 16 22297455 22297537 83 + 2.058 1.987 -0.238
ENSG00000058600 E011 3.6996053 0.0049029505 7.499291e-01 8.367453e-01 16 22298953 22299036 84 + 0.623 0.673 0.215
ENSG00000058600 E012 0.2955422 0.0287081080 7.597813e-01   16 22302470 22302805 336 + 0.146 0.102 -0.594
ENSG00000058600 E013 0.1472490 0.0425202749 3.317093e-01   16 22302806 22302930 125 + 0.146 0.000 -9.531
ENSG00000058600 E014 85.8793779 0.0124297661 3.853885e-01 5.295772e-01 16 22302931 22302953 23 + 1.953 1.895 -0.194
ENSG00000058600 E015 105.4053319 0.0089331816 2.388130e-01 3.727582e-01 16 22302954 22302973 20 + 2.048 1.980 -0.229
ENSG00000058600 E016 184.2089226 0.0017744659 8.951070e-02 1.743849e-01 16 22302974 22303004 31 + 2.282 2.226 -0.187
ENSG00000058600 E017 234.1026861 0.0016801923 1.081271e-01 2.027632e-01 16 22305156 22305206 51 + 2.382 2.334 -0.162
ENSG00000058600 E018 0.3332198 0.0284401820 7.624223e-01   16 22305379 22305494 116 + 0.146 0.102 -0.592
ENSG00000058600 E019 279.6556579 0.0001925075 6.063309e-04 2.556323e-03 16 22308148 22308204 57 + 2.475 2.402 -0.243
ENSG00000058600 E020 220.0979352 0.0002303743 3.959414e-04 1.758871e-03 16 22308205 22308225 21 + 2.379 2.294 -0.284
ENSG00000058600 E021 1.0780097 0.0560298221 3.774021e-01 5.217278e-01 16 22308226 22308481 256 + 0.415 0.253 -1.016
ENSG00000058600 E022 274.2603436 0.0001875802 6.849166e-03 2.083453e-02 16 22308925 22308961 37 + 2.459 2.402 -0.190
ENSG00000058600 E023 209.4575474 0.0011396230 3.852260e-02 8.831491e-02 16 22308962 22308974 13 + 2.344 2.287 -0.190
ENSG00000058600 E024 303.4858279 0.0012566231 2.650344e-02 6.495654e-02 16 22308975 22309040 66 + 2.502 2.447 -0.184
ENSG00000058600 E025 0.8062000 0.1143626845 9.956917e-01 1.000000e+00 16 22309041 22309427 387 + 0.255 0.253 -0.011
ENSG00000058600 E026 271.7415532 0.0012331368 3.206592e-01 4.638167e-01 16 22309428 22309505 78 + 2.435 2.411 -0.081
ENSG00000058600 E027 141.1447705 0.0002663337 4.492936e-01 5.904851e-01 16 22309506 22309510 5 + 2.121 2.147 0.089
ENSG00000058600 E028 0.9587596 0.0128880192 7.515120e-01 8.379439e-01 16 22309511 22309850 340 + 0.255 0.314 0.406
ENSG00000058600 E029 15.9241710 0.0011552540 3.452966e-03 1.158980e-02 16 22309851 22310321 471 + 1.354 1.111 -0.855
ENSG00000058600 E030 171.1061911 0.0010683122 3.879140e-01 5.320347e-01 16 22313620 22313657 38 + 2.201 2.231 0.102
ENSG00000058600 E031 195.8404174 0.0002048150 8.063719e-01 8.769201e-01 16 22313658 22313727 70 + 2.272 2.282 0.031
ENSG00000058600 E032 110.9716830 0.0002818872 1.580614e-01 2.725383e-01 16 22314079 22314081 3 + 2.060 2.014 -0.154
ENSG00000058600 E033 186.4559927 0.0012740608 5.196586e-01 6.537253e-01 16 22314082 22314128 47 + 2.267 2.248 -0.062
ENSG00000058600 E034 0.2934659 0.0290363502 7.599666e-01   16 22314914 22315088 175 + 0.146 0.102 -0.594
ENSG00000058600 E035 272.6391267 0.0009297749 2.442756e-01 3.792288e-01 16 22315089 22315208 120 + 2.398 2.430 0.107
ENSG00000058600 E036 238.2966909 0.0002099420 5.856693e-01 7.093248e-01 16 22316601 22316686 86 + 2.352 2.368 0.053
ENSG00000058600 E037 4.0738031 0.0107061461 1.957257e-02 5.056820e-02 16 22316981 22316994 14 + 0.869 0.530 -1.420
ENSG00000058600 E038 207.4000666 0.0002139272 1.230801e-01 2.243458e-01 16 22316995 22317039 45 + 2.326 2.290 -0.121
ENSG00000058600 E039 300.0386578 0.0001610214 9.593986e-01 9.785252e-01 16 22317115 22317206 92 + 2.459 2.463 0.013
ENSG00000058600 E040 379.0029037 0.0002873301 5.261624e-01 6.594299e-01 16 22318826 22318946 121 + 2.553 2.568 0.050
ENSG00000058600 E041 316.8215864 0.0002492306 4.541161e-01 5.947894e-01 16 22322850 22322931 82 + 2.493 2.480 -0.045
ENSG00000058600 E042 324.3261261 0.0002773724 4.652359e-03 1.496455e-02 16 22324354 22324413 60 + 2.531 2.474 -0.190
ENSG00000058600 E043 443.3295536 0.0001523228 1.368597e-01 2.437105e-01 16 22324503 22324660 158 + 2.645 2.622 -0.079
ENSG00000058600 E044 241.6431951 0.0001756090 1.774827e-03 6.518848e-03 16 22325205 22325266 62 + 2.315 2.393 0.261
ENSG00000058600 E045 3.1763413 0.0051570563 1.641541e-03 6.093808e-03 16 22325267 22325359 93 + 0.845 0.367 -2.176
ENSG00000058600 E046 730.0613288 0.0001364323 3.576034e-11 6.796438e-10 16 22325761 22326278 518 + 2.782 2.879 0.321
ENSG00000058600 E047 99.6378707 0.0058489268 6.510202e-07 5.628083e-06 16 22326279 22328318 2040 + 2.129 1.874 -0.855
ENSG00000058600 E048 20.1657954 0.0112520756 1.282211e-03 4.917627e-03 16 22328319 22328509 191 + 1.468 1.178 -1.011
ENSG00000058600 E049 248.4977397 0.0017120203 9.186997e-04 3.680008e-03 16 22328510 22328587 78 + 2.311 2.416 0.350
ENSG00000058600 E050 36.6091746 0.0048894446 3.002013e-21 2.210347e-19 16 22328588 22329091 504 + 1.856 1.214 -2.202
ENSG00000058600 E051 78.9158462 0.0057734231 1.697961e-01 2.879465e-01 16 22331435 22332059 625 + 1.929 1.855 -0.251
ENSG00000058600 E052 314.4610911 0.0001898821 2.287891e-10 3.791079e-09 16 22332060 22332122 63 + 2.387 2.528 0.469
ENSG00000058600 E053 371.1876019 0.0001325918 4.373619e-08 4.772003e-07 16 22332123 22332185 63 + 2.479 2.589 0.367
ENSG00000058600 E054 943.4026158 0.0034073365 1.165740e-02 3.271744e-02 16 22333644 22335101 1458 + 2.908 2.981 0.245