ENSG00000058272

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261207 ENSG00000058272 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12A protein_coding protein_coding 11.95167 2.302593 20.27704 0.1489021 0.9117827 3.132975 0.1888319 0.7128340 0.000000 0.71283400 0.0000000 -6.175592 0.06964167 0.2837333 0.00000000 -0.28373333 2.966413e-01 1.766936e-07 FALSE TRUE
ENST00000450142 ENSG00000058272 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12A protein_coding protein_coding 11.95167 2.302593 20.27704 0.1489021 0.9117827 3.132975 6.6300929 1.4405144 10.651209 0.61130645 0.1778663 2.877735 0.62323333 0.6529333 0.52673333 -0.12620000 6.675046e-01 1.766936e-07 FALSE TRUE
ENST00000550007 ENSG00000058272 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12A protein_coding retained_intron 11.95167 2.302593 20.27704 0.1489021 0.9117827 3.132975 0.8353256 0.0000000 1.506568 0.00000000 0.7731971 7.244666 0.04905000 0.0000000 0.07453333 0.07453333 1.875097e-02 1.766936e-07   FALSE
ENST00000550107 ENSG00000058272 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12A protein_coding protein_coding 11.95167 2.302593 20.27704 0.1489021 0.9117827 3.132975 2.4429316 0.0710909 4.272446 0.04338182 0.1743373 5.722751 0.13375417 0.0303000 0.21143333 0.18113333 1.766936e-07 1.766936e-07 FALSE TRUE
ENST00000551781 ENSG00000058272 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R12A protein_coding retained_intron 11.95167 2.302593 20.27704 0.1489021 0.9117827 3.132975 0.5092430 0.0000000 1.863534 0.00000000 1.0586757 7.549618 0.03207083 0.0000000 0.09033333 0.09033333 4.686609e-01 1.766936e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000058272 E001 0.4427912 0.2127903310 3.767969e-01 5.211087e-01 12 79773563 79773567 5 - 0.094 0.270 1.831
ENSG00000058272 E002 155.5333968 0.0243619203 1.707965e-13 4.703718e-12 12 79773568 79774405 838 - 1.877 2.505 2.102
ENSG00000058272 E003 267.3496121 0.0005885989 8.532221e-34 1.910643e-31 12 79774406 79775540 1135 - 2.201 2.568 1.227
ENSG00000058272 E004 80.0503432 0.0003699640 4.281528e-02 9.620488e-02 12 79775541 79775777 237 - 1.730 1.886 0.526
ENSG00000058272 E005 51.5617748 0.0005894704 7.704369e-03 2.303665e-02 12 79775778 79775913 136 - 1.531 1.748 0.737
ENSG00000058272 E006 20.4385321 0.0115966525 1.961292e-02 5.065795e-02 12 79775914 79775917 4 - 1.131 1.420 1.017
ENSG00000058272 E007 24.5737136 0.0040413352 8.254129e-02 1.635177e-01 12 79775918 79775922 5 - 1.225 1.434 0.731
ENSG00000058272 E008 23.9051988 0.0058791649 3.041886e-01 4.462034e-01 12 79775923 79775928 6 - 1.225 1.375 0.525
ENSG00000058272 E009 21.5028808 0.0043596018 6.639263e-01 7.718696e-01 12 79775929 79775930 2 - 1.192 1.286 0.332
ENSG00000058272 E010 20.9116947 0.0039127742 5.688207e-01 6.954365e-01 12 79775931 79775934 4 - 1.178 1.286 0.381
ENSG00000058272 E011 48.7228747 0.0021213492 3.758285e-01 5.202328e-01 12 79775935 79776015 81 - 1.528 1.641 0.385
ENSG00000058272 E012 48.1548433 0.0011593570 9.729727e-01 9.871246e-01 12 79778550 79778600 51 - 1.533 1.586 0.182
ENSG00000058272 E013 2.9507565 0.0052246214 3.738033e-01 5.182171e-01 12 79778601 79779320 720 - 0.450 0.653 0.941
ENSG00000058272 E014 0.2966881 0.0270020453 1.000000e+00   12 79779321 79779338 18 - 0.094 0.000 -9.835
ENSG00000058272 E015 0.4439371 0.0215702528 1.000000e+00 1.000000e+00 12 79779339 79779351 13 - 0.135 0.000 -10.456
ENSG00000058272 E016 2.0743993 0.0802819688 1.096855e-01 2.050989e-01 12 79779352 79780745 1394 - 0.431 0.000 -12.118
ENSG00000058272 E017 45.1827046 0.0013964372 7.464940e-01 8.342244e-01 12 79781815 79781862 48 - 1.507 1.534 0.092
ENSG00000058272 E018 0.7405115 0.3122699713 7.058079e-01 8.041024e-01 12 79781863 79782341 479 - 0.206 0.000 -10.162
ENSG00000058272 E019 0.4847352 0.2572109248 3.673159e-01 5.116759e-01 12 79782571 79782595 25 - 0.095 0.273 1.847
ENSG00000058272 E020 51.9382703 0.0104016453 2.217670e-01 3.524985e-01 12 79786374 79786478 105 - 1.579 1.524 -0.187
ENSG00000058272 E021 0.4804688 0.0222738967 3.498365e-01 4.940216e-01 12 79786479 79786776 298 - 0.094 0.273 1.848
ENSG00000058272 E022 3.4482659 0.0127212482 9.859298e-01 9.952069e-01 12 79786777 79788647 1871 - 0.519 0.559 0.187
ENSG00000058272 E023 50.9797162 0.0009971483 7.467601e-01 8.344380e-01 12 79788648 79788783 136 - 1.551 1.624 0.249
ENSG00000058272 E024 2.0787914 0.0850366137 9.476132e-01 9.710373e-01 12 79789598 79789680 83 - 0.390 0.436 0.247
ENSG00000058272 E025 20.8758033 0.0008901225 9.150779e-01 9.502293e-01 12 79790467 79790483 17 - 1.185 1.245 0.213
ENSG00000058272 E026 0.5975289 0.0320873691 7.552307e-01 8.406406e-01 12 79793797 79793862 66 - 0.172 0.000 -10.744
ENSG00000058272 E027 42.8918501 0.0051508650 4.794883e-01 6.178570e-01 12 79793863 79793928 66 - 1.496 1.487 -0.031
ENSG00000058272 E028 79.0086780 0.0004208834 2.301535e-02 5.777994e-02 12 79795638 79795759 122 - 1.764 1.682 -0.277
ENSG00000058272 E029 82.8661252 0.0003391355 1.036019e-02 2.965038e-02 12 79796782 79796916 135 - 1.786 1.690 -0.325
ENSG00000058272 E030 50.9610144 0.0011724612 5.647927e-01 6.920204e-01 12 79796917 79796950 34 - 1.566 1.576 0.035
ENSG00000058272 E031 39.0541654 0.0040740439 2.062764e-01 3.340532e-01 12 79797195 79797233 39 - 1.464 1.405 -0.204
ENSG00000058272 E032 29.2346742 0.0230399342 1.276051e-01 2.308106e-01 12 79797234 79797268 35 - 1.351 1.202 -0.523
ENSG00000058272 E033 32.4309741 0.0110034992 3.099619e-01 4.523221e-01 12 79797269 79797329 61 - 1.383 1.325 -0.200
ENSG00000058272 E034 24.4553635 0.0013257589 3.750363e-01 5.194490e-01 12 79797330 79797346 17 - 1.263 1.223 -0.142
ENSG00000058272 E035 36.6903453 0.0065598268 4.951194e-02 1.082990e-01 12 79797347 79797395 49 - 1.446 1.305 -0.487
ENSG00000058272 E036 53.4303995 0.0106226210 1.529521e-02 4.115719e-02 12 79798494 79798584 91 - 1.607 1.434 -0.591
ENSG00000058272 E037 71.9713114 0.0029800664 4.889550e-03 1.562260e-02 12 79805592 79805768 177 - 1.729 1.586 -0.484
ENSG00000058272 E038 0.8899506 0.0136746146 4.281934e-01 5.709931e-01 12 79805769 79805816 48 - 0.237 0.000 -11.479
ENSG00000058272 E039 37.4006684 0.0005434965 7.315362e-04 3.012703e-03 12 79806166 79806297 132 - 1.464 1.200 -0.923
ENSG00000058272 E040 19.5038819 0.0009506254 6.708577e-03 2.046636e-02 12 79806298 79806333 36 - 1.199 0.902 -1.083
ENSG00000058272 E041 3.1127568 0.0050239802 1.849130e-01 3.073776e-01 12 79806816 79807225 410 - 0.535 0.273 -1.475
ENSG00000058272 E042 55.4865915 0.0004465892 1.309865e-03 5.010195e-03 12 79807226 79807330 105 - 1.622 1.435 -0.642
ENSG00000058272 E043 58.7494590 0.0004379909 2.268509e-06 1.743386e-05 12 79808483 79808577 95 - 1.658 1.342 -1.087
ENSG00000058272 E044 80.9616705 0.0003590548 3.766038e-06 2.757458e-05 12 79809795 79810010 216 - 1.788 1.545 -0.826
ENSG00000058272 E045 0.1515154 0.0430115695 8.707000e-01   12 79810395 79810511 117 - 0.050 0.000 -8.707
ENSG00000058272 E046 56.5371747 0.0004867803 1.001311e-04 5.224327e-04 12 79817394 79817518 125 - 1.636 1.391 -0.840
ENSG00000058272 E047 65.5343485 0.0003650455 9.722331e-08 9.894528e-07 12 79820774 79820931 158 - 1.707 1.359 -1.195
ENSG00000058272 E048 38.4389633 0.0005972959 1.770100e-04 8.654162e-04 12 79821078 79821111 34 - 1.479 1.175 -1.059
ENSG00000058272 E049 47.0573062 0.0005533765 2.203479e-05 1.352610e-04 12 79821112 79821166 55 - 1.563 1.245 -1.099
ENSG00000058272 E050 42.4979186 0.0718326680 4.368033e-02 9.780180e-02 12 79822116 79822190 75 - 1.516 1.258 -0.891
ENSG00000058272 E051 0.4482035 0.0286623021 1.000000e+00 1.000000e+00 12 79828128 79828319 192 - 0.135 0.000 -10.381
ENSG00000058272 E052 36.3420627 0.0461970914 2.618535e-02 6.432572e-02 12 79828320 79828370 51 - 1.450 1.184 -0.932
ENSG00000058272 E053 36.1238992 0.0006685107 6.822800e-04 2.834373e-03 12 79828371 79828464 94 - 1.450 1.175 -0.959
ENSG00000058272 E054 51.1594023 0.0004848402 1.293740e-03 4.955273e-03 12 79832332 79832491 160 - 1.589 1.391 -0.683
ENSG00000058272 E055 0.0000000       12 79832492 79832596 105 -      
ENSG00000058272 E056 51.2622613 0.0004638010 3.882675e-06 2.832677e-05 12 79845302 79845420 119 - 1.603 1.266 -1.161
ENSG00000058272 E057 0.0000000       12 79848788 79848931 144 -      
ENSG00000058272 E058 45.4009060 0.0006405995 2.365294e-07 2.235236e-06 12 79872808 79872938 131 - 1.558 1.121 -1.525
ENSG00000058272 E059 0.0000000       12 79913797 79913911 115 -      
ENSG00000058272 E060 53.0460507 0.0067360669 1.966880e-04 9.496878e-04 12 79934695 79934951 257 - 1.612 1.325 -0.988
ENSG00000058272 E061 18.6023016 0.0010363136 6.174480e-02 1.295619e-01 12 79934952 79935130 179 - 1.168 0.988 -0.650
ENSG00000058272 E062 0.4482035 0.0286623021 1.000000e+00 1.000000e+00 12 79935353 79935460 108 - 0.135 0.000 -10.381