ENSG00000058262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000243253 ENSG00000058262 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC61A1 protein_coding protein_coding 272.0855 366.7605 234.3333 6.118307 2.094207 -0.6462539 233.89680 298.67022 206.5085091 22.33444 2.45108730 -0.5323306 0.86585417 0.8136000 0.881233333 0.06763333 0.573313795 1.280143e-48 FALSE TRUE
ENST00000498837 ENSG00000058262 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC61A1 protein_coding processed_transcript 272.0855 366.7605 234.3333 6.118307 2.094207 -0.6462539 11.76335 40.18502 0.5196687 23.96827 0.05683794 -6.2457827 0.03457917 0.1103667 0.002233333 -0.10813333 0.007694111 1.280143e-48 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000058262 E001 7.576338 0.0032512979 5.687414e-03 1.778433e-02 3 128051641 128051669 29 + 1.057 0.807 -0.945
ENSG00000058262 E002 12.109477 0.0261436888 1.488903e-02 4.023798e-02 3 128051670 128051729 60 + 1.220 0.998 -0.803
ENSG00000058262 E003 15.904941 0.0031348676 1.338317e-04 6.759087e-04 3 128051730 128051841 112 + 1.354 1.093 -0.920
ENSG00000058262 E004 17.048775 0.0456037653 1.213334e-02 3.385163e-02 3 128051842 128051910 69 + 1.374 1.123 -0.883
ENSG00000058262 E005 17.996073 0.0124551517 1.138631e-03 4.432734e-03 3 128051911 128052191 281 + 1.394 1.159 -0.828
ENSG00000058262 E006 6.535342 0.0024697899 6.592548e-04 2.749512e-03 3 128052244 128052344 101 + 1.043 0.698 -1.333
ENSG00000058262 E007 87.744095 0.0301766522 1.009096e-01 1.918533e-01 3 128052345 128052425 81 + 1.970 1.912 -0.194
ENSG00000058262 E008 122.335940 0.0224632077 1.428111e-01 2.518630e-01 3 128052426 128052436 11 + 2.095 2.067 -0.093
ENSG00000058262 E009 530.197994 0.0103714218 1.307747e-03 5.002801e-03 3 128052437 128052488 52 + 2.763 2.678 -0.281
ENSG00000058262 E010 946.359074 0.0083533884 4.069242e-04 1.801392e-03 3 128052489 128052559 71 + 3.012 2.932 -0.266
ENSG00000058262 E011 2.092868 0.0090314811 5.445120e-01 6.749733e-01 3 128052560 128052758 199 + 0.396 0.551 0.782
ENSG00000058262 E012 5.960565 0.0071415238 1.444999e-01 2.541436e-01 3 128052759 128052834 76 + 0.907 0.787 -0.465
ENSG00000058262 E013 1345.741970 0.0054387131 3.677943e-05 2.138463e-04 3 128052835 128052902 68 + 3.160 3.089 -0.236
ENSG00000058262 E014 1469.185722 0.0031328927 1.245770e-06 1.013865e-05 3 128055516 128055581 66 + 3.190 3.132 -0.193
ENSG00000058262 E015 1738.923266 0.0015011227 2.850726e-11 5.510832e-10 3 128055673 128055751 79 + 3.263 3.206 -0.188
ENSG00000058262 E016 2408.813236 0.0018780019 2.508102e-12 5.765013e-11 3 128056709 128056840 132 + 3.413 3.341 -0.240
ENSG00000058262 E017 2231.337912 0.0023597455 9.215310e-09 1.143670e-07 3 128060102 128060211 110 + 3.373 3.313 -0.197
ENSG00000058262 E018 2570.341206 0.0015419772 1.163549e-10 2.031246e-09 3 128060508 128060661 154 + 3.427 3.379 -0.160
ENSG00000058262 E019 1154.905320 0.0009897384 9.256909e-11 1.642804e-09 3 128064877 128064898 22 + 3.076 3.034 -0.139
ENSG00000058262 E020 1445.549628 0.0007889661 2.182625e-09 3.036585e-08 3 128064899 128064938 40 + 3.160 3.140 -0.067
ENSG00000058262 E021 2106.753055 0.0009041225 3.596331e-09 4.808145e-08 3 128064939 128065020 82 + 3.322 3.305 -0.057
ENSG00000058262 E022 1286.265082 0.0007174995 1.190009e-08 1.446728e-07 3 128065021 128065037 17 + 3.107 3.092 -0.049
ENSG00000058262 E023 59.243116 0.0006832010 2.883100e-13 7.678823e-12 3 128065038 128065256 219 + 1.908 1.644 -0.895
ENSG00000058262 E024 31.336610 0.0068076712 5.298586e-05 2.967105e-04 3 128066609 128066703 95 + 1.618 1.397 -0.758
ENSG00000058262 E025 2835.195300 0.0001766736 1.033153e-11 2.146374e-10 3 128066954 128067151 198 + 3.431 3.447 0.054
ENSG00000058262 E026 2325.285504 0.0005027232 5.308674e-01 6.633942e-01 3 128067421 128067612 192 + 3.310 3.381 0.233
ENSG00000058262 E027 9.411830 0.0018828771 4.039730e-01 5.477332e-01 3 128067781 128067982 202 + 1.013 0.993 -0.075
ENSG00000058262 E028 1632.329623 0.0002201849 3.467000e-01 4.908254e-01 3 128067983 128068059 77 + 3.144 3.233 0.294
ENSG00000058262 E029 18843.552698 0.0058355506 7.255458e-12 1.544757e-10 3 128069476 128071683 2208 + 4.103 4.341 0.791