ENSG00000057935

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405094 ENSG00000057935 HEK293_OSMI2_2hA HEK293_TMG_2hB MTA3 protein_coding protein_coding 13.50193 13.11893 15.8791 0.726654 0.8172879 0.2752885 1.4825401 2.0140448 1.584326 0.1814043 0.1002450 -0.34429473 0.11581250 0.15500000 0.1008667 -0.054133333 0.18140332 0.0006486645 FALSE TRUE
ENST00000406911 ENSG00000057935 HEK293_OSMI2_2hA HEK293_TMG_2hB MTA3 protein_coding protein_coding 13.50193 13.11893 15.8791 0.726654 0.8172879 0.2752885 6.7872183 7.7494426 7.299526 0.3166188 0.1894939 -0.08617519 0.50400417 0.59163333 0.4629333 -0.128700000 0.04340554 0.0006486645 FALSE TRUE
MSTRG.18282.1 ENSG00000057935 HEK293_OSMI2_2hA HEK293_TMG_2hB MTA3 protein_coding   13.50193 13.11893 15.8791 0.726654 0.8172879 0.2752885 0.7008517 0.6687392 1.070990 0.0928026 0.1877365 0.67142346 0.05360417 0.05203333 0.0668000 0.014766667 0.65669336 0.0006486645 TRUE TRUE
MSTRG.18282.15 ENSG00000057935 HEK293_OSMI2_2hA HEK293_TMG_2hB MTA3 protein_coding   13.50193 13.11893 15.8791 0.726654 0.8172879 0.2752885 1.4399424 0.3336896 2.573325 0.1722321 0.8864612 2.91005074 0.09872917 0.02420000 0.1573667 0.133166667 0.08759112 0.0006486645 FALSE TRUE
MSTRG.18282.3 ENSG00000057935 HEK293_OSMI2_2hA HEK293_TMG_2hB MTA3 protein_coding   13.50193 13.11893 15.8791 0.726654 0.8172879 0.2752885 1.8688831 1.7746081 2.197895 0.2818374 0.1883758 0.30706407 0.13615833 0.13376667 0.1397000 0.005933333 0.96200766 0.0006486645 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000057935 E001 8.8016299 0.0528964659 6.573342e-01 7.666923e-01 2 42494541 42494568 28 + 0.942 1.011 0.254
ENSG00000057935 E002 10.5666625 0.0144337003 2.573893e-01 3.944957e-01 2 42494569 42494628 60 + 0.974 1.104 0.474
ENSG00000057935 E003 16.2247503 0.0141527042 4.310561e-01 5.736483e-01 2 42494629 42494810 182 + 1.181 1.258 0.273
ENSG00000057935 E004 20.1830278 0.0097008542 6.563017e-01 7.659454e-01 2 42494811 42495006 196 + 1.298 1.338 0.138
ENSG00000057935 E005 14.8570074 0.0215747026 4.692422e-01 6.085082e-01 2 42495163 42495254 92 + 1.243 1.168 -0.266
ENSG00000057935 E006 0.0000000       2 42568045 42568110 66 +      
ENSG00000057935 E007 0.0000000       2 42568111 42568167 57 +      
ENSG00000057935 E008 0.0000000       2 42568168 42568226 59 +      
ENSG00000057935 E009 0.0000000       2 42568517 42568631 115 +      
ENSG00000057935 E010 0.1515154 0.0423003300 4.608132e-01   2 42568632 42568674 43 + 0.126 0.000 -10.264
ENSG00000057935 E011 1.7756468 0.0075350143 1.196138e-02 3.343732e-02 2 42568675 42568728 54 + 0.640 0.212 -2.423
ENSG00000057935 E012 3.2494192 0.0046643878 3.220802e-02 7.625140e-02 2 42568729 42568737 9 + 0.782 0.460 -1.422
ENSG00000057935 E013 5.2767107 0.0030568847 1.545672e-01 2.678389e-01 2 42568738 42568740 3 + 0.889 0.706 -0.721
ENSG00000057935 E014 33.6134337 0.0008499633 5.291251e-04 2.268413e-03 2 42568741 42568773 33 + 1.638 1.433 -0.701
ENSG00000057935 E015 0.0000000       2 42569384 42569896 513 +      
ENSG00000057935 E016 73.3476378 0.0004410150 1.317459e-04 6.665295e-04 2 42570437 42570504 68 + 1.949 1.797 -0.513
ENSG00000057935 E017 107.5252821 0.0003396956 7.249589e-06 4.972979e-05 2 42579107 42579200 94 + 2.109 1.962 -0.496
ENSG00000057935 E018 1.7380789 0.0085244083 6.109900e-01 7.302179e-01 2 42581785 42581908 124 + 0.371 0.461 0.487
ENSG00000057935 E019 134.1903794 0.0003547605 1.131294e-05 7.424195e-05 2 42609458 42609584 127 + 2.196 2.066 -0.435
ENSG00000057935 E020 0.3686942 0.0262938781 9.592250e-01 9.784500e-01 2 42613675 42614194 520 + 0.126 0.119 -0.097
ENSG00000057935 E021 94.5354233 0.0029669126 7.524939e-02 1.519344e-01 2 42640173 42640236 64 + 2.020 1.946 -0.249
ENSG00000057935 E022 129.2701114 0.0051842075 1.671458e-02 4.430878e-02 2 42644127 42644244 118 + 2.170 2.065 -0.352
ENSG00000057935 E023 0.0000000       2 42644245 42644245 1 +      
ENSG00000057935 E024 123.0040207 0.0006052811 1.660077e-03 6.153929e-03 2 42656200 42656302 103 + 2.142 2.043 -0.333
ENSG00000057935 E025 0.1817044 0.0399689209 5.167618e-01   2 42659520 42659762 243 + 0.000 0.119 9.790
ENSG00000057935 E026 109.2073223 0.0034135569 7.220687e-01 8.162795e-01 2 42659763 42659862 100 + 2.045 2.030 -0.048
ENSG00000057935 E027 150.6900234 0.0057954181 4.784854e-01 6.168981e-01 2 42682401 42682589 189 + 2.159 2.191 0.109
ENSG00000057935 E028 0.1451727 0.0432235683 4.603284e-01   2 42682590 42682706 117 + 0.126 0.000 -10.263
ENSG00000057935 E029 96.2474885 0.0006761819 3.085821e-03 1.051835e-02 2 42695765 42695839 75 + 1.922 2.036 0.383
ENSG00000057935 E030 95.1625449 0.0003246335 9.900198e-03 2.851631e-02 2 42697776 42697834 59 + 1.925 2.023 0.327
ENSG00000057935 E031 1.3295290 0.1096943634 6.671240e-02 1.379293e-01 2 42698415 42698494 80 + 0.126 0.501 2.690
ENSG00000057935 E032 5.5380011 0.0030246543 1.883951e-03 6.864557e-03 2 42702307 42703648 1342 + 0.989 0.583 -1.629
ENSG00000057935 E033 3.8200926 0.0361379942 5.005508e-02 1.092675e-01 2 42703649 42704193 545 + 0.828 0.506 -1.378
ENSG00000057935 E034 35.1810162 0.0020828200 3.257464e-01 4.691833e-01 2 42704194 42704196 3 + 1.523 1.587 0.220
ENSG00000057935 E035 134.8015239 0.0002396513 4.971911e-02 1.086619e-01 2 42704197 42704318 122 + 2.094 2.157 0.211
ENSG00000057935 E036 59.8293433 0.0006155618 6.567477e-01 7.662479e-01 2 42707903 42707910 8 + 1.795 1.779 -0.054
ENSG00000057935 E037 137.1770010 0.0052188449 9.848460e-01 9.945900e-01 2 42707911 42708054 144 + 2.136 2.144 0.026
ENSG00000057935 E038 0.0000000       2 42708502 42708563 62 +      
ENSG00000057935 E039 124.2399598 0.0030835589 8.660705e-03 2.543435e-02 2 42708874 42709014 141 + 2.031 2.143 0.374
ENSG00000057935 E040 67.7389878 0.0003578921 1.466962e-06 1.175499e-05 2 42709015 42709074 60 + 1.703 1.918 0.723
ENSG00000057935 E041 37.4400972 0.0005922192 1.109287e-04 5.720910e-04 2 42709075 42709096 22 + 1.441 1.671 0.786
ENSG00000057935 E042 46.8629826 0.0004663917 2.262768e-06 1.739398e-05 2 42709097 42709544 448 + 1.519 1.772 0.862
ENSG00000057935 E043 15.1041818 0.0013048026 7.280802e-02 1.480133e-01 2 42718988 42719074 87 + 1.291 1.142 -0.525
ENSG00000057935 E044 22.6391837 0.0008304533 6.957754e-03 2.111298e-02 2 42722889 42723035 147 + 1.472 1.284 -0.652
ENSG00000057935 E045 2.2048327 0.0075303720 2.294425e-01 3.617624e-01 2 42723036 42723334 299 + 0.605 0.410 -0.947
ENSG00000057935 E046 0.4439371 0.0215619180 7.378298e-02 1.495705e-01 2 42739966 42740060 95 + 0.303 0.000 -11.848
ENSG00000057935 E047 0.0000000       2 42752234 42752307 74 +      
ENSG00000057935 E048 49.1168012 0.0021202136 4.213145e-01 5.644511e-01 2 42753374 42754248 875 + 1.723 1.684 -0.132
ENSG00000057935 E049 25.4356255 0.0074571589 3.181273e-01 4.610767e-01 2 42754249 42754632 384 + 1.373 1.452 0.276
ENSG00000057935 E050 129.0181155 0.0050973479 1.047965e-04 5.441666e-04 2 42754633 42756947 2315 + 2.003 2.181 0.596