ENSG00000057608

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380191 ENSG00000057608 HEK293_OSMI2_2hA HEK293_TMG_2hB GDI2 protein_coding protein_coding 101.4099 56.51291 150.0448 6.836763 4.670534 1.408582 88.83357 54.10064 128.6921 6.833502 3.00246 1.250051 0.9017625 0.9560667 0.8581333 -0.09793333 2.362929e-07 1.464082e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000057608 E001 18.7217232 1.057481e-03 4.744232e-04 2.062275e-03 10 5765223 5765228 6 - 1.143 1.461 1.112
ENSG00000057608 E002 229.0830122 1.455074e-02 1.342095e-11 2.737760e-10 10 5765229 5765326 98 - 2.113 2.601 1.628
ENSG00000057608 E003 1578.7978088 7.049706e-03 7.251571e-14 2.101879e-12 10 5765327 5765848 522 - 3.038 3.361 1.075
ENSG00000057608 E004 654.0864523 3.484623e-04 1.432369e-14 4.614933e-13 10 5765849 5765953 105 - 2.730 2.898 0.561
ENSG00000057608 E005 1054.2993657 3.159571e-04 1.577320e-02 4.222152e-02 10 5765954 5766152 199 - 2.972 3.046 0.246
ENSG00000057608 E006 622.4296080 3.786334e-04 3.411342e-01 4.850554e-01 10 5766241 5766295 55 - 2.761 2.786 0.084
ENSG00000057608 E007 4.3489186 4.201003e-01 7.081561e-01 8.058703e-01 10 5766296 5766493 198 - 0.670 0.762 0.380
ENSG00000057608 E008 732.7467933 1.001258e-04 6.608671e-01 7.694627e-01 10 5766494 5766638 145 - 2.828 2.865 0.121
ENSG00000057608 E009 764.5899064 1.276435e-04 2.729553e-01 4.119281e-01 10 5768213 5768384 172 - 2.850 2.877 0.090
ENSG00000057608 E010 2.7094237 6.583156e-02 1.832643e-02 4.784521e-02 10 5768385 5769389 1005 - 0.348 0.819 2.184
ENSG00000057608 E011 657.2932176 9.622592e-05 1.996375e-04 9.622617e-04 10 5773842 5773941 100 - 2.797 2.784 -0.045
ENSG00000057608 E012 728.4460470 2.139076e-04 1.129896e-06 9.276907e-06 10 5785142 5785273 132 - 2.847 2.813 -0.111
ENSG00000057608 E013 389.5940037 3.777899e-04 6.750211e-06 4.667009e-05 10 5785852 5785865 14 - 2.581 2.526 -0.185
ENSG00000057608 E014 739.5759851 7.955203e-04 6.775659e-07 5.834408e-06 10 5785866 5785981 116 - 2.860 2.802 -0.194
ENSG00000057608 E015 458.3563424 2.054313e-03 2.831834e-05 1.694352e-04 10 5785982 5786005 24 - 2.660 2.576 -0.281
ENSG00000057608 E016 458.8600015 1.109238e-03 4.035098e-05 2.323446e-04 10 5786006 5786050 45 - 2.654 2.593 -0.204
ENSG00000057608 E017 360.8155863 1.717132e-04 5.167161e-06 3.665480e-05 10 5794885 5794907 23 - 2.548 2.496 -0.176
ENSG00000057608 E018 606.1405983 1.419471e-04 2.775523e-14 8.545661e-13 10 5794908 5794989 82 - 2.782 2.700 -0.274
ENSG00000057608 E019 416.8398615 8.745072e-04 5.885323e-11 1.078295e-09 10 5794990 5795019 30 - 2.629 2.513 -0.387
ENSG00000057608 E020 543.1661602 6.243202e-04 6.788977e-13 1.712495e-11 10 5796763 5796862 100 - 2.741 2.634 -0.356
ENSG00000057608 E021 478.4248346 5.081702e-03 2.561333e-05 1.548892e-04 10 5800598 5800705 108 - 2.691 2.558 -0.445
ENSG00000057608 E022 3.7237332 3.394649e-02 7.216137e-01 8.159176e-01 10 5802310 5802340 31 - 0.651 0.616 -0.155
ENSG00000057608 E023 0.8073328 1.567513e-02 6.536597e-01 7.640859e-01 10 5802341 5802354 14 - 0.208 0.308 0.751
ENSG00000057608 E024 3.4010338 4.850004e-03 7.738439e-01 8.541173e-01 10 5811874 5811956 83 - 0.588 0.665 0.336
ENSG00000057608 E025 0.4355181 6.121790e-01 6.034620e-01 7.242576e-01 10 5812315 5812367 53 - 0.207 0.000 -10.049
ENSG00000057608 E026 576.4587391 6.564120e-03 1.392014e-06 1.120371e-05 10 5813214 5813442 229 - 2.783 2.607 -0.583
ENSG00000057608 E027 0.1482932 4.115975e-02 2.106841e-01   10 5814108 5814540 433 - 0.000 0.181 10.867
ENSG00000057608 E028 0.0000000       10 5814541 5814587 47 -      
ENSG00000057608 E029 0.0000000       10 5814588 5814762 175 -      
ENSG00000057608 E030 0.0000000       10 5842067 5842132 66 -