ENSG00000057252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367619 ENSG00000057252 HEK293_OSMI2_2hA HEK293_TMG_2hB SOAT1 protein_coding protein_coding 14.69531 5.829785 21.84006 1.051768 1.083265 1.90365 7.4935509 5.4858920 9.846501 0.9913265 0.1948122 0.8427219 0.64259167 0.94090000 0.4524000 -0.48850000 6.907501e-38 6.907501e-38 FALSE TRUE
ENST00000426956 ENSG00000057252 HEK293_OSMI2_2hA HEK293_TMG_2hB SOAT1 protein_coding protein_coding 14.69531 5.829785 21.84006 1.051768 1.083265 1.90365 6.1646366 0.0000000 10.184102 0.0000000 1.1150353 9.9935190 0.28879167 0.00000000 0.4636667 0.46366667 3.584601e-35 6.907501e-38 FALSE FALSE
ENST00000540564 ENSG00000057252 HEK293_OSMI2_2hA HEK293_TMG_2hB SOAT1 protein_coding protein_coding 14.69531 5.829785 21.84006 1.051768 1.083265 1.90365 0.8978242 0.3103608 1.692915 0.0276189 0.1093434 2.4102369 0.05502917 0.05486667 0.0783000 0.02343333 4.286838e-01 6.907501e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000057252 E001 2.775395 0.0055594479 1.279227e-01 2.312679e-01 1 179293714 179293780 67 + 0.614 0.404 -1.018
ENSG00000057252 E002 5.755070 0.0031173874 1.913989e-02 4.964463e-02 1 179293781 179293796 16 + 0.882 0.609 -1.112
ENSG00000057252 E003 76.635115 0.0147921280 6.275144e-04 2.634009e-03 1 179293797 179293936 140 + 1.920 1.727 -0.650
ENSG00000057252 E004 0.000000       1 179294320 179294401 82 +      
ENSG00000057252 E005 114.154749 0.0014623806 5.543010e-11 1.021008e-09 1 179302677 179302802 126 + 2.091 1.898 -0.648
ENSG00000057252 E006 73.705723 0.0003225150 7.513000e-06 5.133874e-05 1 179323437 179323495 59 + 1.887 1.765 -0.409
ENSG00000057252 E007 111.063715 0.0002832456 6.824401e-06 4.712112e-05 1 179335506 179335657 152 + 2.053 1.971 -0.277
ENSG00000057252 E008 86.320972 0.0003121477 5.365985e-04 2.296762e-03 1 179337837 179337896 60 + 1.939 1.878 -0.205
ENSG00000057252 E009 118.381854 0.0003414345 1.296511e-08 1.565257e-07 1 179339438 179339545 108 + 2.093 1.971 -0.410
ENSG00000057252 E010 200.189048 0.0001850460 4.227611e-10 6.710023e-09 1 179341028 179341310 283 + 2.307 2.220 -0.291
ENSG00000057252 E011 104.929774 0.0011707521 4.367904e-05 2.496037e-04 1 179342114 179342192 79 + 2.028 1.941 -0.292
ENSG00000057252 E012 102.592269 0.0003091076 3.063997e-03 1.045525e-02 1 179342862 179342943 82 + 2.002 1.971 -0.104
ENSG00000057252 E013 75.820163 0.0031389646 6.408007e-01 7.539813e-01 1 179343590 179343635 46 + 1.844 1.893 0.165
ENSG00000057252 E014 117.025858 0.0011975724 4.015679e-01 5.452838e-01 1 179344947 179345076 130 + 2.032 2.077 0.151
ENSG00000057252 E015 113.492233 0.0020992807 5.180905e-01 6.523768e-01 1 179347600 179347697 98 + 1.999 2.098 0.333
ENSG00000057252 E016 122.150544 0.0014070182 5.607754e-01 6.887072e-01 1 179348844 179348942 99 + 2.033 2.131 0.327
ENSG00000057252 E017 136.878196 0.0002905878 2.519920e-01 3.883134e-01 1 179350296 179350431 136 + 2.075 2.190 0.384
ENSG00000057252 E018 143.480319 0.0008599835 7.145753e-01 8.107207e-01 1 179351317 179351462 146 + 2.105 2.194 0.297
ENSG00000057252 E019 951.229302 0.0061727832 2.572132e-09 3.534107e-08 1 179353585 179358680 5096 + 2.862 3.095 0.777