ENSG00000056586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357244 ENSG00000056586 HEK293_OSMI2_2hA HEK293_TMG_2hB RC3H2 protein_coding protein_coding 15.79766 9.0332 24.41893 1.442186 0.5689141 1.433685 8.8544403 3.0306582 14.7849361 0.39568565 0.4333839 2.2826479 0.51362083 0.3389333 0.6053000 0.2663667 3.242445e-16 3.242445e-16 FALSE TRUE
ENST00000398671 ENSG00000056586 HEK293_OSMI2_2hA HEK293_TMG_2hB RC3H2 protein_coding protein_coding 15.79766 9.0332 24.41893 1.442186 0.5689141 1.433685 0.9873605 1.9288005 0.6863781 0.28416505 0.6863781 -1.4772216 0.09815833 0.2193000 0.0271000 -0.1922000 5.425977e-02 3.242445e-16 FALSE FALSE
ENST00000471874 ENSG00000056586 HEK293_OSMI2_2hA HEK293_TMG_2hB RC3H2 protein_coding protein_coding 15.79766 9.0332 24.41893 1.442186 0.5689141 1.433685 2.4273780 3.5588661 2.6688840 0.94940604 0.1395177 -0.4138336 0.20062917 0.3803333 0.1096667 -0.2706667 2.753668e-08 3.242445e-16 FALSE TRUE
MSTRG.33334.5 ENSG00000056586 HEK293_OSMI2_2hA HEK293_TMG_2hB RC3H2 protein_coding   15.79766 9.0332 24.41893 1.442186 0.5689141 1.433685 2.2524564 0.1048284 4.5791933 0.05343221 0.1639929 5.3206897 0.10257083 0.0140000 0.1876333 0.1736333 4.553983e-05 3.242445e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000056586 E001 747.7243945 0.0099160661 1.701252e-05 1.072108e-04 9 122844556 122847554 2999 - 2.726 2.948 0.740
ENSG00000056586 E002 386.3084044 0.0031783772 1.388615e-12 3.322835e-11 9 122847555 122849436 1882 - 2.530 2.316 -0.714
ENSG00000056586 E003 24.0021116 0.0021545292 3.554404e-07 3.238140e-06 9 122849437 122849571 135 - 1.375 0.824 -2.004
ENSG00000056586 E004 79.4965937 0.0003413072 3.392397e-13 8.943495e-12 9 122849572 122849798 227 - 1.868 1.478 -1.326
ENSG00000056586 E005 46.8302541 0.0061217457 3.420918e-05 2.005702e-04 9 122849799 122849822 24 - 1.636 1.333 -1.043
ENSG00000056586 E006 35.9152477 0.0048988873 1.210852e-04 6.189669e-04 9 122851081 122851099 19 - 1.524 1.220 -1.058
ENSG00000056586 E007 83.0571597 0.0019879665 1.752248e-12 4.125240e-11 9 122851100 122851229 130 - 1.889 1.488 -1.360
ENSG00000056586 E008 70.3076728 0.0003623889 2.383414e-17 1.105880e-15 9 122851323 122851436 114 - 1.828 1.288 -1.847
ENSG00000056586 E009 1.1061103 0.0172920598 5.472576e-01 6.773396e-01 9 122851437 122851569 133 - 0.242 0.383 0.922
ENSG00000056586 E010 1.0277484 0.0277616920 7.627880e-01 8.463176e-01 9 122853745 122853773 29 - 0.278 0.232 -0.343
ENSG00000056586 E011 13.6664619 0.0013111112 5.332938e-19 3.033051e-17 9 122853774 122853951 178 - 0.727 1.586 3.113
ENSG00000056586 E012 117.4143875 0.0023300372 6.522643e-02 1.354083e-01 9 122853952 122854086 135 - 1.953 2.078 0.421
ENSG00000056586 E013 94.4778948 0.0045610281 1.864916e-02 4.856211e-02 9 122854185 122854266 82 - 1.850 2.017 0.561
ENSG00000056586 E014 70.3752309 0.0065016190 5.698272e-02 1.214295e-01 9 122854531 122854581 51 - 1.726 1.890 0.552
ENSG00000056586 E015 61.4221789 0.0067406379 3.625237e-01 5.069386e-01 9 122854582 122854615 34 - 1.684 1.793 0.369
ENSG00000056586 E016 145.2817904 0.0002463817 3.499850e-01 4.941651e-01 9 122855184 122855397 214 - 2.058 2.139 0.269
ENSG00000056586 E017 113.2113318 0.0002507787 5.514692e-01 6.809241e-01 9 122855732 122855878 147 - 1.962 1.985 0.077
ENSG00000056586 E018 103.7521063 0.0002767418 5.213183e-01 6.551910e-01 9 122857923 122858093 171 - 1.925 1.945 0.067
ENSG00000056586 E019 181.8059496 0.0002429847 3.636967e-01 5.081101e-01 9 122858669 122859102 434 - 2.167 2.185 0.061
ENSG00000056586 E020 111.0468147 0.0066651808 9.254128e-01 9.570395e-01 9 122859917 122860131 215 - 1.947 1.991 0.148
ENSG00000056586 E021 102.0232557 0.0003148938 2.249051e-02 5.670278e-02 9 122865349 122865541 193 - 1.932 1.877 -0.184
ENSG00000056586 E022 67.4027936 0.0004118157 1.603495e-02 4.281383e-02 9 122865542 122865623 82 - 1.760 1.672 -0.296
ENSG00000056586 E023 51.1010144 0.0006237481 2.725182e-03 9.448020e-03 9 122865624 122865657 34 - 1.650 1.498 -0.519
ENSG00000056586 E024 8.3226400 0.0025247079 1.402257e-03 5.314236e-03 9 122873786 122875368 1583 - 0.762 1.181 1.565
ENSG00000056586 E025 86.5154956 0.0006075521 1.413178e-02 3.852397e-02 9 122877471 122877583 113 - 1.863 1.787 -0.256
ENSG00000056586 E026 73.3643486 0.0086499864 5.373780e-02 1.157937e-01 9 122879755 122879873 119 - 1.797 1.698 -0.336
ENSG00000056586 E027 87.0507270 0.0003288274 5.724077e-04 2.430648e-03 9 122879993 122880125 133 - 1.875 1.750 -0.422
ENSG00000056586 E028 115.7168262 0.0002485258 1.872336e-05 1.168919e-04 9 122880594 122880794 201 - 2.000 1.860 -0.469
ENSG00000056586 E029 96.2394728 0.0046133815 1.097851e-03 4.296404e-03 9 122883204 122883379 176 - 1.922 1.776 -0.494
ENSG00000056586 E030 0.3697384 0.0250248605 1.769731e-02 4.648074e-02 9 122890170 122890170 1 - 0.000 0.383 12.046
ENSG00000056586 E031 13.7633488 0.0070626183 3.542409e-20 2.303016e-18 9 122890171 122890311 141 - 0.689 1.628 3.415
ENSG00000056586 E032 149.4140351 0.0020610252 1.530849e-07 1.500025e-06 9 122890312 122890545 234 - 2.026 2.273 0.828
ENSG00000056586 E033 106.1415159 0.0005121957 4.328791e-04 1.900877e-03 9 122892909 122893026 118 - 1.898 2.086 0.632
ENSG00000056586 E034 151.5038786 0.0031219737 5.372445e-02 1.157715e-01 9 122897279 122897576 298 - 2.064 2.193 0.431
ENSG00000056586 E035 1.1728074 0.1159187971 6.677091e-01 7.748670e-01 9 122897577 122898110 534 - 0.311 0.231 -0.570
ENSG00000056586 E036 44.9860191 0.0011569051 9.817406e-01 9.926335e-01 9 122905110 122905359 250 - 1.562 1.609 0.162