ENSG00000055917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338086 ENSG00000055917 HEK293_OSMI2_2hA HEK293_TMG_2hB PUM2 protein_coding protein_coding 17.29606 4.302836 27.36636 0.4967878 0.8456025 2.666222 5.4412637 3.11095489 6.243143 0.97038089 1.29319031 1.002594 0.48055417 0.690100000 0.22603333 -0.46406667 3.395861e-02 3.144215e-06 FALSE TRUE
ENST00000361078 ENSG00000055917 HEK293_OSMI2_2hA HEK293_TMG_2hB PUM2 protein_coding protein_coding 17.29606 4.302836 27.36636 0.4967878 0.8456025 2.666222 4.3117736 0.74623743 8.126738 0.40575690 1.88752213 3.427539 0.20874167 0.197866667 0.30166667 0.10380000 6.122362e-01 3.144215e-06 FALSE TRUE
ENST00000440577 ENSG00000055917 HEK293_OSMI2_2hA HEK293_TMG_2hB PUM2 protein_coding protein_coding 17.29606 4.302836 27.36636 0.4967878 0.8456025 2.666222 1.4448177 0.13774102 1.693106 0.08148694 0.91708427 3.527026 0.06175417 0.036200000 0.06026667 0.02406667 9.499191e-01 3.144215e-06 FALSE TRUE
MSTRG.18016.4 ENSG00000055917 HEK293_OSMI2_2hA HEK293_TMG_2hB PUM2 protein_coding   17.29606 4.302836 27.36636 0.4967878 0.8456025 2.666222 0.9555038 0.02897822 2.759370 0.01777105 0.86647453 6.150746 0.04503333 0.007433333 0.09923333 0.09180000 1.648980e-03 3.144215e-06 FALSE TRUE
MSTRG.18016.7 ENSG00000055917 HEK293_OSMI2_2hA HEK293_TMG_2hB PUM2 protein_coding   17.29606 4.302836 27.36636 0.4967878 0.8456025 2.666222 1.5424171 0.09875074 3.215775 0.02306578 0.05369524 4.890548 0.06169583 0.023966667 0.11783333 0.09386667 3.144215e-06 3.144215e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000055917 E001 4.0056432 0.1784707577 1.713728e-03 6.324845e-03 2 20248691 20248736 46 - 0.329 1.147 3.525
ENSG00000055917 E002 41.1320040 0.0483245763 4.457167e-08 4.855677e-07 2 20248737 20248859 123 - 1.235 2.032 2.719
ENSG00000055917 E003 381.3212462 0.0366981987 4.371568e-06 3.152691e-05 2 20248860 20249863 1004 - 2.315 2.820 1.684
ENSG00000055917 E004 316.7741295 0.0003519582 4.034137e-42 1.595522e-39 2 20249864 20250633 770 - 2.273 2.671 1.327
ENSG00000055917 E005 270.1129840 0.0004977506 2.059211e-03 7.408959e-03 2 20250634 20251322 689 - 2.262 2.431 0.566
ENSG00000055917 E006 204.5702081 0.0009228719 7.941102e-01 8.684511e-01 2 20251323 20251716 394 - 2.156 2.247 0.302
ENSG00000055917 E007 166.5465233 0.0002179721 6.220501e-02 1.303558e-01 2 20253822 20254014 193 - 2.081 2.094 0.044
ENSG00000055917 E008 133.8846886 0.0002682664 7.026156e-04 2.908520e-03 2 20254863 20254984 122 - 1.997 1.932 -0.220
ENSG00000055917 E009 123.4234297 0.0002820106 5.045993e-05 2.841363e-04 2 20255216 20255341 126 - 1.968 1.862 -0.356
ENSG00000055917 E010 135.4959760 0.0107714920 1.739102e-01 2.932746e-01 2 20256033 20256170 138 - 1.994 1.979 -0.048
ENSG00000055917 E011 12.4634530 0.0014104986 8.460635e-01 9.042841e-01 2 20258237 20258242 6 - 0.979 1.078 0.364
ENSG00000055917 E012 112.2374135 0.0196631760 3.488104e-01 4.930284e-01 2 20258243 20258371 129 - 1.911 1.906 -0.016
ENSG00000055917 E013 111.7493955 0.0007720851 1.938185e-02 5.016372e-02 2 20260337 20260466 130 - 1.913 1.882 -0.106
ENSG00000055917 E014 159.3131096 0.0021354818 2.324564e-04 1.101891e-03 2 20263193 20263460 268 - 2.075 1.984 -0.303
ENSG00000055917 E015 117.6609014 0.0003129838 3.382457e-05 1.985980e-04 2 20278583 20278819 237 - 1.947 1.831 -0.393
ENSG00000055917 E016 116.4669431 0.0002692433 2.833615e-05 1.695256e-04 2 20282947 20283231 285 - 1.944 1.825 -0.401
ENSG00000055917 E017 52.8964395 0.0005479253 3.117018e-04 1.427317e-03 2 20283343 20283486 144 - 1.617 1.434 -0.626
ENSG00000055917 E018 56.3205121 0.0004270192 8.867677e-07 7.448259e-06 2 20290652 20290790 139 - 1.651 1.361 -0.996
ENSG00000055917 E019 57.6508094 0.0038182723 7.290209e-05 3.941294e-04 2 20294376 20294518 143 - 1.656 1.421 -0.804
ENSG00000055917 E020 52.4254509 0.0004639614 7.010068e-02 1.435343e-01 2 20297553 20297678 126 - 1.594 1.552 -0.144
ENSG00000055917 E021 22.3052017 0.0010194806 5.405747e-01 6.717100e-01 2 20307978 20307980 3 - 1.209 1.344 0.476
ENSG00000055917 E022 56.8807595 0.0004104467 4.736001e-03 1.519388e-02 2 20307981 20308071 91 - 1.640 1.530 -0.374
ENSG00000055917 E023 72.4836687 0.0009254316 2.659140e-06 2.014017e-05 2 20308314 20308413 100 - 1.755 1.530 -0.766
ENSG00000055917 E024 80.0886271 0.0003212397 2.087298e-08 2.424776e-07 2 20308414 20308489 76 - 1.801 1.530 -0.918
ENSG00000055917 E025 82.3669495 0.0003196094 3.945922e-07 3.561594e-06 2 20308490 20308584 95 - 1.807 1.581 -0.764
ENSG00000055917 E026 98.2778949 0.0003219865 8.055552e-10 1.215919e-08 2 20311494 20311639 146 - 1.887 1.618 -0.907
ENSG00000055917 E027 50.0656930 0.0742072601 5.622203e-03 1.761035e-02 2 20311640 20311663 24 - 1.607 1.237 -1.281
ENSG00000055917 E028 64.4567476 0.0004626849 5.335268e-06 3.772443e-05 2 20312236 20312298 63 - 1.704 1.473 -0.787
ENSG00000055917 E029 103.5469206 0.0012873835 5.991394e-08 6.353138e-07 2 20312299 20312423 125 - 1.905 1.676 -0.770
ENSG00000055917 E030 81.3989711 0.0183271764 9.165442e-04 3.672671e-03 2 20318537 20318592 56 - 1.801 1.567 -0.795
ENSG00000055917 E031 68.2031641 0.0003769770 1.769634e-08 2.083863e-07 2 20318593 20318645 53 - 1.733 1.420 -1.067
ENSG00000055917 E032 14.2659259 0.0019177473 6.060448e-04 2.555326e-03 2 20326261 20326385 125 - 1.094 0.641 -1.757
ENSG00000055917 E033 71.4935904 0.0003400516 1.844655e-10 3.109390e-09 2 20327310 20327378 69 - 1.758 1.392 -1.252
ENSG00000055917 E034 0.1451727 0.0433852337 1.000000e+00   2 20327379 20327383 5 - 0.051 0.000 -8.200
ENSG00000055917 E035 9.0133064 0.0018422726 1.402643e-05 9.005845e-05 2 20331717 20331937 221 - 0.937 0.000 -13.903
ENSG00000055917 E036 4.8843527 0.0031896005 2.100709e-02 5.360483e-02 2 20332967 20333063 97 - 0.700 0.266 -2.250
ENSG00000055917 E037 1.3201701 0.0314242691 7.414364e-01 8.306205e-01 2 20333409 20333499 91 - 0.302 0.265 -0.251
ENSG00000055917 E038 1.8907403 0.1407370224 3.704709e-02 8.555968e-02 2 20350205 20350301 97 - 0.244 0.725 2.513
ENSG00000055917 E039 39.7323135 0.0015411135 2.084438e-04 1.000179e-03 2 20350597 20350809 213 - 1.501 1.252 -0.864
ENSG00000055917 E040 1.3767622 0.2214056906 8.253582e-01 8.900081e-01 2 20350810 20350844 35 - 0.303 0.266 -0.251
ENSG00000055917 E041 0.4482035 0.0279924523 1.000000e+00 1.000000e+00 2 20352166 20352234 69 - 0.139 0.000 -9.740