ENSG00000055147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351797 ENSG00000055147 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM114A2 protein_coding protein_coding 10.23931 3.589693 18.1207 0.2008976 0.4291575 2.332489 1.927577 1.0524073 3.645865 0.20975447 0.3036830 1.7828757 0.2118250 0.2889667 0.20156667 -0.0874000 0.28746516 0.00822604 FALSE TRUE
ENST00000520667 ENSG00000055147 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM114A2 protein_coding protein_coding 10.23931 3.589693 18.1207 0.2008976 0.4291575 2.332489 1.844504 1.2545169 2.404023 0.26627825 0.1967879 0.9328531 0.2187708 0.3549333 0.13330000 -0.2216333 0.02713683 0.00822604 FALSE TRUE
ENST00000522858 ENSG00000055147 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM114A2 protein_coding protein_coding 10.23931 3.589693 18.1207 0.2008976 0.4291575 2.332489 1.232288 0.7873218 1.807698 0.08290977 0.3250418 1.1888785 0.1500958 0.2197333 0.09956667 -0.1201667 0.02328581 0.00822604 FALSE TRUE
MSTRG.27201.3 ENSG00000055147 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM114A2 protein_coding   10.23931 3.589693 18.1207 0.2008976 0.4291575 2.332489 3.344098 0.1230748 7.130611 0.12307477 0.3764540 5.7457385 0.2453167 0.0309000 0.39300000 0.3621000 0.00822604 0.00822604 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000055147 E001 56.8518576 0.0010087848 7.278403e-02 1.479825e-01 5 153990148 153991702 1555 - 1.668 1.772 0.351
ENSG00000055147 E002 106.7291967 0.0004484858 1.490218e-10 2.552828e-09 5 153991703 153992498 796 - 1.892 2.137 0.822
ENSG00000055147 E003 52.8378839 0.0004706140 2.296232e-07 2.176486e-06 5 153992499 153992687 189 - 1.580 1.855 0.933
ENSG00000055147 E004 36.9328761 0.0007305960 4.834171e-09 6.326029e-08 5 153992688 153992713 26 - 1.397 1.758 1.234
ENSG00000055147 E005 89.5170438 0.0003795728 2.299114e-07 2.179000e-06 5 153992714 153992954 241 - 1.828 2.045 0.729
ENSG00000055147 E006 85.6037947 0.0188871093 3.857901e-01 5.299792e-01 5 153992955 153993110 156 - 1.846 1.933 0.291
ENSG00000055147 E007 0.9201396 0.0152833001 8.619864e-01 9.150346e-01 5 153994592 153994743 152 - 0.257 0.219 -0.304
ENSG00000055147 E008 55.2636368 0.0155390975 7.378138e-02 1.495689e-01 5 153994919 153994972 54 - 1.640 1.800 0.541
ENSG00000055147 E009 0.3686942 0.0264334270 3.082033e-01 4.504700e-01 5 153994973 153995307 335 - 0.065 0.219 2.020
ENSG00000055147 E010 47.4986281 0.0069662607 3.235093e-02 7.653521e-02 5 153997803 153997875 73 - 1.578 1.734 0.529
ENSG00000055147 E011 68.6842585 0.0005207111 6.841945e-01 7.872144e-01 5 154002251 154002390 140 - 1.765 1.792 0.089
ENSG00000055147 E012 78.4474599 0.0003311014 9.024178e-01 9.418524e-01 5 154002847 154002969 123 - 1.824 1.835 0.038
ENSG00000055147 E013 60.6727253 0.0004045206 6.245630e-02 1.307797e-01 5 154011241 154011320 80 - 1.738 1.639 -0.335
ENSG00000055147 E014 0.5858876 0.0201722215 8.089631e-01 8.786618e-01 5 154026312 154026398 87 - 0.172 0.219 0.431
ENSG00000055147 E015 59.6611226 0.0017089102 1.491955e-01 2.605636e-01 5 154026399 154026522 124 - 1.726 1.646 -0.274
ENSG00000055147 E016 82.5844074 0.0005816441 7.928860e-01 8.675531e-01 5 154027176 154027294 119 - 1.850 1.844 -0.023
ENSG00000055147 E017 72.5860507 0.0029516918 5.271388e-01 6.602854e-01 5 154027295 154027334 40 - 1.802 1.772 -0.102
ENSG00000055147 E018 0.4428904 0.6130530083 7.170349e-02 1.461872e-01 5 154027335 154027546 212 - 0.000 0.380 13.103
ENSG00000055147 E019 80.2134342 0.0003846455 8.296374e-01 8.930347e-01 5 154028149 154028242 94 - 1.839 1.835 -0.014
ENSG00000055147 E020 57.4436164 0.0004457717 8.850332e-01 9.305109e-01 5 154028243 154028279 37 - 1.692 1.705 0.046
ENSG00000055147 E021 48.1321230 0.0021584394 3.856271e-01 5.298070e-01 5 154028280 154028283 4 - 1.629 1.576 -0.180
ENSG00000055147 E022 75.4294604 0.0003837469 2.210072e-01 3.516289e-01 5 154029489 154029580 92 - 1.823 1.768 -0.185
ENSG00000055147 E023 47.5415173 0.0006323757 4.702234e-01 6.094273e-01 5 154033791 154033816 26 - 1.622 1.583 -0.133
ENSG00000055147 E024 59.5020437 0.0004322122 3.851085e-02 8.829546e-02 5 154033817 154033877 61 - 1.731 1.619 -0.382
ENSG00000055147 E025 32.0528787 0.0013286212 1.275398e-02 3.533339e-02 5 154033878 154033883 6 - 1.483 1.286 -0.683
ENSG00000055147 E026 53.4730974 0.0004559287 1.077944e-04 5.579596e-04 5 154034278 154034349 72 - 1.707 1.465 -0.828
ENSG00000055147 E027 38.3865841 0.0029289438 3.294092e-04 1.498549e-03 5 154034350 154034377 28 - 1.573 1.286 -0.989
ENSG00000055147 E028 33.0270720 0.0054616746 2.027154e-02 5.205533e-02 5 154034744 154034762 19 - 1.497 1.301 -0.681
ENSG00000055147 E029 70.0710956 0.0033721559 1.076680e-04 5.573666e-04 5 154034763 154034847 85 - 1.822 1.583 -0.809
ENSG00000055147 E030 55.4750555 0.0004681664 1.168024e-06 9.563015e-06 5 154034848 154034875 28 - 1.734 1.424 -1.060
ENSG00000055147 E031 45.0666985 0.0007861248 8.928443e-03 2.610055e-02 5 154034876 154034907 32 - 1.626 1.455 -0.585
ENSG00000055147 E032 45.1635101 0.0005454061 1.808327e-01 3.022472e-01 5 154034908 154034946 39 - 1.609 1.528 -0.275
ENSG00000055147 E033 33.0604304 0.0008323825 7.302849e-01 8.222973e-01 5 154034947 154034967 21 - 1.464 1.445 -0.068
ENSG00000055147 E034 0.8836079 0.0133110316 2.200590e-01 3.504765e-01 5 154036242 154036385 144 - 0.295 0.000 -10.842
ENSG00000055147 E035 2.9862335 0.0051831393 5.471063e-02 1.174904e-01 5 154036722 154037310 589 - 0.610 0.219 -2.230
ENSG00000055147 E036 19.0448292 0.0012207902 1.676121e-04 8.249237e-04 5 154038293 154038387 95 - 1.299 0.878 -1.531
ENSG00000055147 E037 13.5516586 0.0013366345 1.221635e-02 3.405060e-02 5 154038388 154038434 47 - 1.144 0.839 -1.134
ENSG00000055147 E038 6.0187755 0.0486284684 3.496723e-01 4.938745e-01 5 154038435 154038826 392 - 0.813 0.633 -0.736
ENSG00000055147 E039 2.3617353 0.0112133900 5.084023e-01 6.438216e-01 5 154038827 154038835 9 - 0.492 0.364 -0.681
ENSG00000055147 E040 2.3617353 0.0112133900 5.084023e-01 6.438216e-01 5 154038836 154038856 21 - 0.492 0.364 -0.681
ENSG00000055147 E041 27.0995570 0.0074867064 4.930881e-01 6.301415e-01 5 154038857 154038936 80 - 1.388 1.329 -0.206