ENSG00000054282

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366541 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding protein_coding 6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 2.0999125 1.4017181 1.9822516 0.15445404 0.30014084 0.4969478 0.3146417 0.35600000 0.21130000 -0.14470000 0.091520874 0.003648895 FALSE TRUE
ENST00000463012 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding processed_transcript 6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 0.8219544 0.2733691 1.4114914 0.14707876 0.23906598 2.3266511 0.1140208 0.06940000 0.15103333 0.08163333 0.458648886 0.003648895   FALSE
ENST00000463042 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding processed_transcript 6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 0.3031807 0.1906522 0.3097345 0.01376999 0.01257765 0.6721777 0.0520250 0.04840000 0.03303333 -0.01536667 0.518892836 0.003648895   FALSE
ENST00000490065 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding processed_transcript 6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 1.2637835 0.3291920 2.1378700 0.05611859 0.28621873 2.6627328 0.1681458 0.08323333 0.22760000 0.14436667 0.003648895 0.003648895 FALSE FALSE
MSTRG.3394.3 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding   6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 0.7785164 0.5939282 1.7389933 0.24343949 0.07504185 1.5340759 0.1071500 0.15103333 0.18563333 0.03460000 0.749639664 0.003648895 FALSE TRUE
MSTRG.3394.4 ENSG00000054282 HEK293_OSMI2_2hA HEK293_TMG_2hB SDCCAG8 protein_coding   6.939732 3.938722 9.378639 0.05826304 0.09127409 1.24953 0.8888329 0.4875314 0.7367448 0.15265106 0.16349742 0.5858276 0.1292875 0.12270000 0.07823333 -0.04446667 0.645818538 0.003648895 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000054282 E001 1.2553459 0.0632600729 0.0469218499 0.1036835292 1 243256034 243256040 7 + 0.175 0.548 2.354
ENSG00000054282 E002 2.7312833 0.0056238601 0.4064311651 0.5500779778 1 243256041 243256053 13 + 0.509 0.645 0.616
ENSG00000054282 E003 6.6902945 0.0315168559 0.4898809434 0.6272530201 1 243256054 243256061 8 + 0.913 0.818 -0.367
ENSG00000054282 E004 40.4204865 0.0005324688 0.8231453166 0.8885354308 1 243256062 243256240 179 + 1.612 1.606 -0.020
ENSG00000054282 E005 0.3289534 0.0286109988 0.6993893988   1 243269136 243269200 65 + 0.096 0.155 0.787
ENSG00000054282 E006 1.7057025 0.0552706328 0.2031337670 0.3301490816 1 243270092 243270104 13 + 0.509 0.268 -1.383
ENSG00000054282 E007 38.5184997 0.0005836624 0.0001077138 0.0005575885 1 243270105 243270257 153 + 1.668 1.446 -0.759
ENSG00000054282 E008 24.9850036 0.0008058121 0.0546896676 0.1174487309 1 243270978 243271024 47 + 1.455 1.324 -0.453
ENSG00000054282 E009 23.8789394 0.0008608888 0.7124084507 0.8091588102 1 243271025 243271063 39 + 1.394 1.374 -0.070
ENSG00000054282 E010 35.3320803 0.0006295640 0.3115095580 0.4539580864 1 243274543 243274656 114 + 1.573 1.519 -0.184
ENSG00000054282 E011 36.5135918 0.0010989525 0.3606050619 0.5049339755 1 243286272 243286353 82 + 1.584 1.536 -0.165
ENSG00000054282 E012 28.5548269 0.0064163637 0.4136675531 0.5570978912 1 243286354 243286382 29 + 1.484 1.427 -0.195
ENSG00000054282 E013 26.2323956 0.0100650369 0.4444811357 0.5860391250 1 243286383 243286397 15 + 1.447 1.391 -0.192
ENSG00000054282 E014 22.0716361 0.0114946240 0.5479061122 0.6778765526 1 243293091 243293117 27 + 1.372 1.326 -0.162
ENSG00000054282 E015 33.1411650 0.0007519510 0.3352733637 0.4790482841 1 243293118 243293219 102 + 1.543 1.490 -0.181
ENSG00000054282 E016 13.8671143 0.0243329871 0.1179450295 0.2169858220 1 243293399 243293494 96 + 1.227 1.053 -0.625
ENSG00000054282 E017 34.0619152 0.0006380964 0.9479907741 0.9713192111 1 243304713 243304777 65 + 1.531 1.541 0.036
ENSG00000054282 E018 0.5879639 0.0215851472 0.6154889748 0.7337461760 1 243304778 243305011 234 + 0.241 0.154 -0.800
ENSG00000054282 E019 26.1790130 0.0042326019 0.5798722955 0.7047005675 1 243305012 243306548 1537 + 1.443 1.411 -0.112
ENSG00000054282 E020 4.0673361 0.0046066274 0.1315751750 0.2363308352 1 243307784 243307883 100 + 0.775 0.552 -0.950
ENSG00000054282 E021 41.9280840 0.0005748160 0.9732668753 0.9873091473 1 243307989 243308177 189 + 1.619 1.624 0.015
ENSG00000054282 E022 34.9805086 0.0009340302 0.6387747988 0.7523498539 1 243316755 243316893 139 + 1.553 1.531 -0.075
ENSG00000054282 E023 0.0000000       1 243316894 243316895 2 +      
ENSG00000054282 E024 33.4031642 0.0006834052 0.0218486004 0.0553658613 1 243330540 243330692 153 + 1.582 1.446 -0.465
ENSG00000054282 E025 0.1515154 0.0429062302 0.7882197763   1 243338753 243338940 188 + 0.096 0.001 -7.606
ENSG00000054282 E026 34.2469218 0.0013761976 0.4039846490 0.5477342880 1 243341039 243341173 135 + 1.558 1.514 -0.154
ENSG00000054282 E027 34.6146546 0.0009874739 0.7476254741 0.8350897862 1 243344215 243344331 117 + 1.549 1.536 -0.046
ENSG00000054282 E028 32.7538998 0.0088002053 0.8108192678 0.8799734063 1 243378721 243378863 143 + 1.514 1.535 0.073
ENSG00000054282 E029 35.5535247 0.0006262532 0.2361682053 0.3697449547 1 243415702 243415829 128 + 1.521 1.596 0.257
ENSG00000054282 E030 22.9406784 0.0010216124 0.0257890000 0.0635077172 1 243417968 243418016 49 + 1.286 1.453 0.579
ENSG00000054282 E031 28.9268037 0.0007682021 0.0190800510 0.0495138341 1 243418017 243418076 60 + 1.390 1.547 0.540
ENSG00000054282 E032 42.4478470 0.0005312531 0.0003441146 0.0015565882 1 243426427 243426558 132 + 1.537 1.733 0.665
ENSG00000054282 E033 2.4616637 0.0062334716 0.2059836387 0.3336609470 1 243475931 243476364 434 + 0.437 0.645 0.980
ENSG00000054282 E034 0.0000000       1 243487815 243487878 64 +      
ENSG00000054282 E035 27.1086464 0.0100585893 0.0222031087 0.0560923914 1 243489014 243489140 127 + 1.353 1.542 0.651
ENSG00000054282 E036 2.1639565 0.0088975513 0.0207970203 0.0531625954 1 243497915 243497959 45 + 0.299 0.685 1.956
ENSG00000054282 E037 32.1293472 0.0347043207 0.0060342473 0.0187011037 1 243499756 243500517 762 + 1.371 1.664 1.007