ENSG00000054118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354618 ENSG00000054118 HEK293_OSMI2_2hA HEK293_TMG_2hB THRAP3 protein_coding protein_coding 71.49287 57.2515 78.42196 6.993728 1.762698 0.4538762 45.016345 45.07453601 41.076860 5.09588685 1.7256529 -0.1339556 0.64999167 0.789600000 0.52463333 -0.2649667 7.151952e-10 1.686865e-74 FALSE TRUE
MSTRG.844.1 ENSG00000054118 HEK293_OSMI2_2hA HEK293_TMG_2hB THRAP3 protein_coding   71.49287 57.2515 78.42196 6.993728 1.762698 0.4538762 5.754061 0.97218617 9.592392 0.97218617 0.2659624 3.2893254 0.07031667 0.016066667 0.12240000 0.1063333 6.161100e-02 1.686865e-74 FALSE TRUE
MSTRG.844.2 ENSG00000054118 HEK293_OSMI2_2hA HEK293_TMG_2hB THRAP3 protein_coding   71.49287 57.2515 78.42196 6.993728 1.762698 0.4538762 1.947463 0.08385057 4.494159 0.03315019 0.2170020 5.5847485 0.02537500 0.001466667 0.05736667 0.0559000 7.169103e-30 1.686865e-74 TRUE TRUE
MSTRG.844.6 ENSG00000054118 HEK293_OSMI2_2hA HEK293_TMG_2hB THRAP3 protein_coding   71.49287 57.2515 78.42196 6.993728 1.762698 0.4538762 6.522305 9.57265845 2.316643 1.69918808 1.1179574 -2.0421761 0.10047083 0.165266667 0.02940000 -0.1358667 4.865742e-04 1.686865e-74 FALSE TRUE
MSTRG.844.8 ENSG00000054118 HEK293_OSMI2_2hA HEK293_TMG_2hB THRAP3 protein_coding   71.49287 57.2515 78.42196 6.993728 1.762698 0.4538762 6.276168 0.00000000 11.223039 0.00000000 0.5633785 10.1335326 0.07570000 0.000000000 0.14300000 0.1430000 1.686865e-74 1.686865e-74 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000054118 E001 0.5889961 0.9119648493 3.942940e-01 5.381481e-01 1 36224329 36224401 73 + 0.333 0.000 -10.218
ENSG00000054118 E002 0.7707005 0.6907708347 6.576092e-01 7.669280e-01 1 36224402 36224404 3 + 0.333 0.137 -1.640
ENSG00000054118 E003 1.0673886 0.0695216780 1.080711e-01 2.026703e-01 1 36224405 36224407 3 + 0.436 0.136 -2.237
ENSG00000054118 E004 5.3360470 0.0246279559 1.840034e-01 3.062390e-01 1 36224408 36224423 16 + 0.883 0.702 -0.718
ENSG00000054118 E005 6.5873301 0.0624139680 1.570895e-01 2.712247e-01 1 36224424 36224431 8 + 0.972 0.761 -0.810
ENSG00000054118 E006 6.5873301 0.0624139680 1.570895e-01 2.712247e-01 1 36224432 36224432 1 + 0.972 0.761 -0.810
ENSG00000054118 E007 22.9139826 0.0655951779 2.824622e-02 6.849663e-02 1 36224433 36224442 10 + 1.500 1.192 -1.072
ENSG00000054118 E008 134.3436706 0.0031730188 5.120365e-12 1.118586e-10 1 36224443 36224505 63 + 2.246 1.968 -0.931
ENSG00000054118 E009 3.0677003 0.0070621776 2.452811e-01 3.803672e-01 1 36224844 36224928 85 + 0.677 0.506 -0.768
ENSG00000054118 E010 2.7271187 0.0056080305 4.259520e-01 5.688177e-01 1 36224929 36224970 42 + 0.621 0.505 -0.527
ENSG00000054118 E011 10.9900498 0.0015913213 5.609050e-03 1.757613e-02 1 36224971 36225102 132 + 1.188 0.921 -0.975
ENSG00000054118 E012 6.6343309 0.0176726128 1.748161e-01 2.944616e-01 1 36225412 36225463 52 + 0.958 0.788 -0.653
ENSG00000054118 E013 0.0000000       1 36238021 36238110 90 +      
ENSG00000054118 E014 239.5408086 0.0037363320 4.328442e-10 6.857421e-09 1 36259382 36259484 103 + 2.479 2.254 -0.750
ENSG00000054118 E015 427.2001624 0.0018574935 3.348390e-18 1.727042e-16 1 36282533 36282700 168 + 2.728 2.505 -0.744
ENSG00000054118 E016 1419.6268479 0.0031971479 1.553166e-12 3.686326e-11 1 36286368 36287270 903 + 3.231 3.052 -0.596
ENSG00000054118 E017 1341.6406680 0.0016045790 3.090872e-08 3.468115e-07 1 36289060 36289717 658 + 3.176 3.074 -0.337
ENSG00000054118 E018 330.7422678 0.0013681347 5.686806e-03 1.778360e-02 1 36289718 36289764 47 + 2.551 2.492 -0.197
ENSG00000054118 E019 589.0990978 0.0004957173 4.684332e-05 2.657700e-04 1 36291374 36291546 173 + 2.801 2.744 -0.190
ENSG00000054118 E020 492.1538828 0.0001106375 2.226244e-06 1.714104e-05 1 36292598 36292709 112 + 2.726 2.666 -0.200
ENSG00000054118 E021 448.4286113 0.0010022534 1.749782e-02 4.603977e-02 1 36293851 36293935 85 + 2.675 2.635 -0.135
ENSG00000054118 E022 10.1056079 0.0016929288 8.196908e-09 1.026765e-07 1 36293936 36294049 114 + 1.256 0.595 -2.536
ENSG00000054118 E023 32.6772956 0.0008534706 3.845796e-20 2.492557e-18 1 36294050 36294241 192 + 1.731 1.105 -2.169
ENSG00000054118 E024 718.5966212 0.0007322387 4.587758e-01 5.990624e-01 1 36296583 36296770 188 + 2.861 2.861 0.001
ENSG00000054118 E025 813.4156137 0.0001438680 7.948432e-03 2.364879e-02 1 36300886 36301084 199 + 2.891 2.942 0.171
ENSG00000054118 E026 211.0569334 0.0003516249 9.880532e-02 1.886552e-01 1 36301553 36301555 3 + 2.303 2.362 0.197
ENSG00000054118 E027 670.8466006 0.0002806192 8.915294e-03 2.606967e-02 1 36301556 36301696 141 + 2.804 2.860 0.187
ENSG00000054118 E028 373.1848358 0.0001683659 9.077325e-02 1.763567e-01 1 36303796 36303831 36 + 2.554 2.603 0.162
ENSG00000054118 E029 1180.4127338 0.0004250559 2.621222e-39 8.681515e-37 1 36303832 36304473 642 + 2.974 3.164 0.633
ENSG00000054118 E030 1471.5093225 0.0052887100 3.654123e-26 4.417758e-24 1 36304474 36305357 884 + 2.955 3.318 1.207