ENSG00000052841

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000039989 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding protein_coding 21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 4.588850 1.4973468 7.416699 0.4586950 1.1173458 2.300710 0.19386250 0.14276667 0.28090000 0.13813333 2.230403e-01 1.849113e-42 FALSE TRUE
ENST00000299240 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding protein_coding 21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 3.758917 1.7786297 5.469301 0.2247000 0.1566945 1.615137 0.16725417 0.17210000 0.20726667 0.03516667 5.468351e-01 1.849113e-42 FALSE TRUE
ENST00000418561 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding protein_coding 21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 1.551201 3.4473991 0.000000 0.4684843 0.0000000 -8.433543 0.12160833 0.32976667 0.00000000 -0.32976667 1.849113e-42 1.849113e-42 FALSE TRUE
ENST00000525029 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding non_stop_decay 21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 1.874780 0.3340855 1.051735 0.1724965 0.6351639 1.625585 0.08222500 0.03116667 0.03976667 0.00860000 1.000000e+00 1.849113e-42 FALSE FALSE
ENST00000525135 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding retained_intron 21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 1.726485 0.6098224 2.000582 0.2996791 0.2086770 1.697687 0.07903333 0.06006667 0.07573333 0.01566667 7.122453e-01 1.849113e-42 FALSE FALSE
MSTRG.5401.1 ENSG00000052841 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC17 protein_coding   21.61228 10.38088 26.38333 0.442421 0.1515349 1.344856 5.229555 1.6889975 7.559297 0.2184947 1.2380198 2.155476 0.21791250 0.16450000 0.28683333 0.12233333 1.719425e-01 1.849113e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000052841 E001 0.5806908 0.8400229652 7.690812e-01 8.508086e-01 11 43358642 43358919 278 + 0.233 0.000 -11.513
ENSG00000052841 E002 0.7279398 0.2707950924 3.154114e-01 4.581744e-01 11 43358920 43358931 12 + 0.277 0.000 -11.724
ENSG00000052841 E003 10.2217230 0.0016049193 4.710338e-03 1.512473e-02 11 43358932 43358953 22 + 1.070 0.711 -1.379
ENSG00000052841 E004 45.5500909 0.0185284358 1.927718e-03 7.001407e-03 11 43358954 43359113 160 + 1.673 1.396 -0.946
ENSG00000052841 E005 1.0340911 0.0117189443 5.274925e-01 6.605514e-01 11 43370079 43370385 307 + 0.317 0.201 -0.866
ENSG00000052841 E006 35.1523139 0.0095531173 5.199636e-03 1.647360e-02 11 43379233 43379257 25 + 1.554 1.327 -0.783
ENSG00000052841 E007 50.1444328 0.0046112000 6.318611e-04 2.650317e-03 11 43379258 43379322 65 + 1.706 1.485 -0.752
ENSG00000052841 E008 82.6431567 0.0014494459 2.813291e-05 1.684267e-04 11 43389652 43389821 170 + 1.916 1.724 -0.647
ENSG00000052841 E009 84.7635385 0.0212323912 2.257175e-02 5.686521e-02 11 43391465 43391576 112 + 1.921 1.758 -0.551
ENSG00000052841 E010 0.2987644 0.0273176773 7.734755e-01   11 43391577 43391788 212 + 0.133 0.000 -10.409
ENSG00000052841 E011 91.3956548 0.0003148923 1.346203e-06 1.087426e-05 11 43391821 43391952 132 + 1.961 1.761 -0.672
ENSG00000052841 E012 3.2479372 0.1461496645 8.002258e-01 8.726457e-01 11 43396136 43396708 573 + 0.609 0.525 -0.382
ENSG00000052841 E013 79.8264198 0.0073106197 1.696329e-02 4.485574e-02 11 43396709 43396818 110 + 1.887 1.757 -0.436
ENSG00000052841 E014 1.7391257 0.0080055542 3.706102e-01 5.150220e-01 11 43396997 43397346 350 + 0.353 0.527 0.912
ENSG00000052841 E015 92.1679362 0.0003030089 2.805278e-02 6.811997e-02 11 43397347 43397491 145 + 1.938 1.864 -0.250
ENSG00000052841 E016 70.6780260 0.0009429570 2.632815e-02 6.460464e-02 11 43397974 43398032 59 + 1.827 1.734 -0.315
ENSG00000052841 E017 75.3504585 0.0011507686 1.342514e-03 5.118132e-03 11 43398033 43398113 81 + 1.864 1.720 -0.487
ENSG00000052841 E018 109.9722608 0.0160290393 1.377990e-01 2.450126e-01 11 43399888 43400048 161 + 2.014 1.928 -0.287
ENSG00000052841 E019 88.3910110 0.0003356778 5.572143e-02 1.192164e-01 11 43401446 43401558 113 + 1.914 1.850 -0.217
ENSG00000052841 E020 2.7529515 0.0128900002 6.227288e-04 2.616008e-03 11 43401559 43401622 64 + 0.317 0.874 2.592
ENSG00000052841 E021 66.3493931 0.0003633760 1.669556e-04 8.220940e-04 11 43403998 43404051 54 + 1.818 1.639 -0.606
ENSG00000052841 E022 90.8517750 0.0003006461 3.123815e-04 1.430119e-03 11 43404052 43404144 93 + 1.944 1.804 -0.474
ENSG00000052841 E023 98.9068702 0.0002999762 1.047154e-02 2.991121e-02 11 43405514 43405629 116 + 1.968 1.881 -0.294
ENSG00000052841 E024 1.1909051 0.0107180627 7.202688e-02 1.467045e-01 11 43405630 43405785 156 + 0.386 0.000 -12.409
ENSG00000052841 E025 112.0196207 0.0002952426 3.907570e-02 8.933536e-02 11 43405786 43405951 166 + 2.018 1.958 -0.202
ENSG00000052841 E026 72.9117885 0.0003788049 2.180013e-02 5.525707e-02 11 43407138 43407215 78 + 1.840 1.748 -0.310
ENSG00000052841 E027 134.8881769 0.0002707611 6.963375e-02 1.427494e-01 11 43407353 43407577 225 + 2.093 2.049 -0.147
ENSG00000052841 E028 144.9962372 0.0002284222 7.705560e-02 1.547724e-01 11 43414590 43414776 187 + 2.124 2.085 -0.133
ENSG00000052841 E029 72.1851261 0.0054121933 8.056805e-01 8.764650e-01 11 43436164 43436221 58 + 1.804 1.835 0.105
ENSG00000052841 E030 99.7173835 0.0098154286 9.521612e-01 9.740488e-01 11 43436222 43436334 113 + 1.948 1.960 0.040
ENSG00000052841 E031 185.0081024 0.0039701812 1.908102e-01 3.147639e-01 11 43443325 43443584 260 + 2.198 2.273 0.249
ENSG00000052841 E032 115.0038816 0.0003466861 2.525910e-02 6.240397e-02 11 43444056 43444209 154 + 1.986 2.087 0.338
ENSG00000052841 E033 5.9290384 0.0026873375 7.684171e-03 2.298663e-02 11 43444210 43444505 296 + 0.872 0.443 -1.864
ENSG00000052841 E034 66.5596836 0.0004030114 2.243876e-09 3.115898e-08 11 43445931 43446719 789 + 1.683 1.972 0.975
ENSG00000052841 E035 14.6764471 0.0452338259 9.748784e-01 9.883540e-01 11 43447584 43448001 418 + 1.138 1.151 0.048
ENSG00000052841 E036 83.5358846 0.0003472183 1.419788e-02 3.867299e-02 11 43448002 43448122 121 + 1.841 1.964 0.413
ENSG00000052841 E037 0.6235652 0.0229257294 1.000000e+00 1.000000e+00 11 43448603 43450081 1479 + 0.187 0.202 0.136
ENSG00000052841 E038 69.2271612 0.0037562046 1.347133e-01 2.407008e-01 11 43450082 43450137 56 + 1.767 1.867 0.336
ENSG00000052841 E039 78.8280088 0.0074603225 3.553662e-01 4.997109e-01 11 43450138 43450241 104 + 1.831 1.905 0.250
ENSG00000052841 E040 0.0000000       11 43451180 43451181 2 +      
ENSG00000052841 E041 70.0963223 0.0010844871 9.681673e-02 1.856159e-01 11 43451182 43451265 84 + 1.771 1.871 0.334
ENSG00000052841 E042 0.1817044 0.0401240312 1.445046e-01   11 43468156 43468363 208 + 0.000 0.202 12.575
ENSG00000052841 E043 0.6017953 0.1575673617 3.507721e-01 4.949444e-01 11 43486416 43486451 36 + 0.235 0.000 -11.413
ENSG00000052841 E044 4.4338733 0.0043656248 3.222899e-04 1.470010e-03 11 43489797 43490238 442 + 0.473 0.994 2.169
ENSG00000052841 E045 89.0342048 0.0004289087 3.593890e-02 8.346737e-02 11 43490239 43490358 120 + 1.871 1.977 0.357
ENSG00000052841 E046 5.3043312 0.2413525526 2.046424e-01 3.319567e-01 11 43490718 43492019 1302 + 0.628 0.962 1.330
ENSG00000052841 E047 127.9904491 0.0013314961 2.651656e-03 9.228197e-03 11 43492020 43492163 144 + 2.020 2.152 0.442
ENSG00000052841 E048 0.0000000       11 43492164 43492164 1 +      
ENSG00000052841 E049 360.1435804 0.0040516224 1.457016e-16 6.147603e-15 11 43493773 43494933 1161 + 2.407 2.700 0.976