ENSG00000052723

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000060969 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding protein_coding 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 10.3772133 3.2419388 17.8081640 0.3961611 0.9727669 2.4539767 0.30152917 0.19590000 0.456900000 0.261000000 5.049693e-03 2.049423e-54 FALSE TRUE
ENST00000369528 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding protein_coding 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 2.0696672 0.4746389 3.3402264 0.4746389 0.3968736 2.7892764 0.05999167 0.02266667 0.085000000 0.062333333 1.527828e-01 2.049423e-54 FALSE TRUE
ENST00000462123 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding processed_transcript 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 1.0295936 1.9616568 0.3098792 0.9853172 0.3098792 -2.6238095 0.04079167 0.12736667 0.008333333 -0.119033333 3.790845e-01 2.049423e-54 FALSE TRUE
ENST00000466657 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding processed_transcript 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 0.7147188 3.8863803 0.0000000 0.6201254 0.0000000 -8.6059907 0.04020000 0.21980000 0.000000000 -0.219800000 2.049423e-54 2.049423e-54   FALSE
ENST00000475335 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding processed_transcript 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 7.9134602 4.3303385 8.5751911 2.5384836 1.4581294 0.9840427 0.30475000 0.21803333 0.219300000 0.001266667 9.036459e-01 2.049423e-54 FALSE TRUE
ENST00000510745 ENSG00000052723 HEK293_OSMI2_2hA HEK293_TMG_2hB SIKE1 protein_coding processed_transcript 29.63044 17.51495 39.10846 2.107467 1.241975 1.158439 5.0946496 2.4315184 5.7496615 0.1215832 0.7857594 1.2382054 0.17174167 0.14400000 0.146066667 0.002066667 9.789785e-01 2.049423e-54   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000052723 E001 1343.875672 0.0091615304 6.488105e-05 3.552976e-04 1 114769479 114774141 4663 - 3.123 2.935 -0.623
ENSG00000052723 E002 167.546020 0.0002204511 2.132084e-02 5.426366e-02 1 114774142 114774344 203 - 2.217 2.064 -0.513
ENSG00000052723 E003 96.196644 0.0003033299 5.578143e-01 6.861514e-01 1 114774345 114774372 28 - 1.967 1.865 -0.344
ENSG00000052723 E004 114.944828 0.0006705324 5.164934e-01 6.510501e-01 1 114776346 114776383 38 - 2.044 1.941 -0.348
ENSG00000052723 E005 133.923047 0.0013450966 5.465250e-01 6.766937e-01 1 114776384 114776459 76 - 2.109 2.007 -0.341
ENSG00000052723 E006 5.035269 0.0619201664 3.775498e-01 5.218872e-01 1 114778932 114779054 123 - 0.713 0.797 0.338
ENSG00000052723 E007 1.215682 0.0510798664 7.798081e-01 8.584545e-01 1 114779098 114779106 9 - 0.320 0.335 0.094
ENSG00000052723 E008 2.332185 0.1995903720 6.247121e-02 1.308035e-01 1 114779107 114779113 7 - 0.357 0.741 1.823
ENSG00000052723 E009 4.399140 0.0229044988 4.582052e-07 4.083048e-06 1 114779114 114779141 28 - 0.390 1.079 2.919
ENSG00000052723 E010 140.149817 0.0002929210 5.681561e-05 3.156465e-04 1 114779142 114779201 60 - 2.088 2.145 0.190
ENSG00000052723 E011 160.627391 0.0028025520 1.285516e-08 1.553072e-07 1 114779202 114779284 83 - 2.120 2.257 0.460
ENSG00000052723 E012 135.242917 0.0014780668 3.043246e-04 1.396913e-03 1 114780110 114780215 106 - 2.071 2.130 0.195
ENSG00000052723 E013 6.248111 0.0663397745 6.805380e-01 7.844068e-01 1 114780216 114780386 171 - 0.856 0.705 -0.604
ENSG00000052723 E014 6.418284 0.0026515109 4.818530e-02 1.059625e-01 1 114780387 114780436 50 - 0.771 0.962 0.734
ENSG00000052723 E015 15.231750 0.0011895486 4.245796e-04 1.868547e-03 1 114780437 114780448 12 - 1.082 1.330 0.881
ENSG00000052723 E016 157.847939 0.0016409699 3.228298e-20 2.112578e-18 1 114780449 114780685 237 - 2.077 2.315 0.794