ENSG00000052126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299275 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding protein_coding 4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 2.0465616 0.66369001 3.1302160 0.143070396 0.21035643 2.220707 0.38760000 0.37546667 0.50420000 0.12873333 0.5851640027 0.0002493986 FALSE TRUE
ENST00000535357 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding processed_transcript 4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 0.4545698 0.35374866 0.8414663 0.183421313 0.09635309 1.227008 0.11825000 0.16696667 0.13396667 -0.03300000 1.0000000000 0.0002493986   FALSE
ENST00000538972 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding protein_coding 4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 0.2838958 0.63145728 0.1423096 0.142681260 0.07865144 -2.074346 0.14170833 0.33626667 0.02196667 -0.31430000 0.0002493986 0.0002493986 FALSE TRUE
ENST00000539256 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding protein_coding 4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 0.1525034 0.00000000 0.0000000 0.000000000 0.00000000 0.000000 0.08169167 0.00000000 0.00000000 0.00000000   0.0002493986 FALSE TRUE
ENST00000540972 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding protein_coding 4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 0.2510152 0.07892747 0.4990485 0.008383972 0.09454151 2.517102 0.06070833 0.04493333 0.07900000 0.03406667 0.4382355555 0.0002493986   FALSE
MSTRG.6917.1 ENSG00000052126 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA5 protein_coding   4.047786 1.882721 6.246004 0.2427106 0.3211336 1.72478 0.7242396 0.08582851 1.4134643 0.085828506 0.22455278 3.892808 0.16825417 0.03976667 0.22453333 0.18476667 0.0883261002 0.0002493986 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000052126 E001 2.2028476 0.0430687569 3.086132e-02 7.364663e-02 12 19129728 19129732 5 + 0.517 0.000 -11.995
ENSG00000052126 E002 3.2369387 0.0369439127 6.144772e-02 1.290715e-01 12 19129733 19129751 19 + 0.624 0.228 -2.214
ENSG00000052126 E003 5.6223074 0.0168915739 6.805866e-02 1.401453e-01 12 19129752 19129793 42 + 0.802 0.488 -1.365
ENSG00000052126 E004 4.9360961 0.0039155003 5.657307e-01 6.927884e-01 12 19129794 19129795 2 + 0.723 0.650 -0.306
ENSG00000052126 E005 9.1381240 0.0025162594 6.011115e-01 7.222520e-01 12 19129796 19129888 93 + 0.944 0.899 -0.171
ENSG00000052126 E006 7.4387497 0.0024530331 9.139312e-01 9.494972e-01 12 19130051 19130059 9 + 0.852 0.859 0.028
ENSG00000052126 E007 12.1230066 0.0084995124 6.412031e-01 7.542861e-01 12 19130060 19130130 71 + 1.026 1.105 0.287
ENSG00000052126 E008 0.2965864 0.1690015568 2.699086e-02   12 19130710 19130888 179 + 0.000 0.373 13.860
ENSG00000052126 E009 11.7460837 0.0041979855 4.170639e-01 5.604447e-01 12 19132393 19132450 58 + 1.045 0.969 -0.280
ENSG00000052126 E010 10.8584104 0.0031964552 4.542102e-01 5.948674e-01 12 19200325 19202003 1679 + 1.007 0.936 -0.266
ENSG00000052126 E011 0.0000000       12 19205262 19205324 63 +      
ENSG00000052126 E012 0.0000000       12 19205325 19205443 119 +      
ENSG00000052126 E013 6.7419794 0.0040065858 2.033372e-02 5.218390e-02 12 19207266 19207733 468 + 0.735 1.056 1.227
ENSG00000052126 E014 0.0000000       12 19236924 19236940 17 +      
ENSG00000052126 E015 0.0000000       12 19236941 19237034 94 +      
ENSG00000052126 E016 0.0000000       12 19243180 19243443 264 +      
ENSG00000052126 E017 11.7117392 0.0017519026 6.768655e-01 7.817052e-01 12 19253940 19254023 84 + 1.026 1.000 -0.096
ENSG00000052126 E018 16.1847467 0.0012418907 3.179567e-01 4.608683e-01 12 19255045 19255165 121 + 1.164 1.082 -0.295
ENSG00000052126 E019 10.3314187 0.0016512939 3.864823e-01 5.306569e-01 12 19257433 19257473 41 + 0.987 0.899 -0.330
ENSG00000052126 E020 12.5415630 0.0017030132 6.972296e-01 7.974020e-01 12 19257474 19257537 64 + 1.051 1.030 -0.078
ENSG00000052126 E021 11.8771111 0.0014722640 8.581716e-01 9.124985e-01 12 19260949 19261021 73 + 1.027 1.029 0.011
ENSG00000052126 E022 15.9323360 0.0013052621 7.407752e-03 2.227884e-02 12 19265750 19265850 101 + 1.191 0.899 -1.067
ENSG00000052126 E023 22.9795614 0.0055387762 2.975210e-02 7.147137e-02 12 19269770 19269885 116 + 1.326 1.130 -0.691
ENSG00000052126 E024 0.1817044 0.0396096555 9.743102e-02   12 19270188 19270205 18 + 0.000 0.229 13.241
ENSG00000052126 E025 42.2231424 0.0005621956 4.420556e-03 1.432056e-02 12 19274516 19274983 468 + 1.578 1.402 -0.603
ENSG00000052126 E026 38.5668343 0.0006885419 1.611354e-01 2.765890e-01 12 19283280 19283636 357 + 1.530 1.458 -0.247
ENSG00000052126 E027 22.3584828 0.0008836217 9.534268e-01 9.748636e-01 12 19283637 19283745 109 + 1.280 1.310 0.105
ENSG00000052126 E028 15.7730643 0.0011898324 1.476332e-01 2.584737e-01 12 19287473 19287556 84 + 1.164 1.029 -0.488
ENSG00000052126 E029 0.1451727 0.0427272487 1.000000e+00   12 19290677 19290796 120 + 0.062 0.000 -9.865
ENSG00000052126 E030 0.3289534 0.0291400097 2.899320e-01   12 19291644 19291697 54 + 0.062 0.229 2.181
ENSG00000052126 E031 1.4038295 0.0101798773 3.128168e-01 4.553466e-01 12 19306399 19307560 1162 + 0.283 0.488 1.180
ENSG00000052126 E032 0.0000000       12 19314765 19314813 49 +      
ENSG00000052126 E033 0.1482932 0.0414572533 9.806576e-02   12 19314814 19314894 81 + 0.000 0.228 13.232
ENSG00000052126 E034 0.1472490 0.0435235255 1.000000e+00   12 19319646 19320020 375 + 0.062 0.000 -9.866
ENSG00000052126 E035 0.1472490 0.0435235255 1.000000e+00   12 19320021 19320056 36 + 0.062 0.000 -9.866
ENSG00000052126 E036 0.0000000       12 19320536 19320561 26 +      
ENSG00000052126 E037 15.6563460 0.0024127349 2.593150e-02 6.380568e-02 12 19320562 19320624 63 + 1.173 0.936 -0.867
ENSG00000052126 E038 0.0000000       12 19320625 19320885 261 +      
ENSG00000052126 E039 0.0000000       12 19321584 19321660 77 +      
ENSG00000052126 E040 16.3650683 0.0271432129 1.256989e-01 2.281446e-01 12 19322310 19322390 81 + 1.186 1.003 -0.661
ENSG00000052126 E041 19.9383983 0.0088234841 8.218001e-02 1.629486e-01 12 19322518 19322667 150 + 1.269 1.106 -0.580
ENSG00000052126 E042 14.9720381 0.0043397530 1.921981e-01 3.165132e-01 12 19336515 19336616 102 + 1.151 1.029 -0.442
ENSG00000052126 E043 19.2722207 0.0009530138 6.265762e-01 7.425061e-01 12 19343323 19343419 97 + 1.232 1.210 -0.075
ENSG00000052126 E044 8.8617222 0.0018869615 7.328048e-01 8.242014e-01 12 19343420 19343434 15 + 0.921 0.899 -0.083
ENSG00000052126 E045 15.0405794 0.0012986780 5.789823e-01 7.039757e-01 12 19345842 19345888 47 + 1.111 1.191 0.287
ENSG00000052126 E046 0.4762024 0.2436464244 5.459602e-01 6.762160e-01 12 19346994 19347182 189 + 0.116 0.229 1.185
ENSG00000052126 E047 25.2236918 0.0008615993 7.930824e-01 8.676828e-01 12 19348399 19348519 121 + 1.335 1.338 0.010
ENSG00000052126 E048 25.8403387 0.0007237979 2.180089e-01 3.480217e-01 12 19353884 19354002 119 + 1.359 1.279 -0.279
ENSG00000052126 E049 37.9885890 0.0008380095 7.811302e-01 8.593857e-01 12 19358228 19358437 210 + 1.501 1.508 0.021
ENSG00000052126 E050 26.0373147 0.0092368319 2.731848e-01 4.121857e-01 12 19359412 19359546 135 + 1.317 1.437 0.418
ENSG00000052126 E051 22.2886642 0.0008201904 6.030908e-01 7.239313e-01 12 19361582 19361706 125 + 1.269 1.338 0.242
ENSG00000052126 E052 30.5053003 0.0007208230 4.713642e-01 6.104922e-01 12 19365964 19366109 146 + 1.401 1.478 0.268
ENSG00000052126 E053 25.6506816 0.0007423453 9.104731e-03 2.654454e-02 12 19369693 19369798 106 + 1.287 1.507 0.765
ENSG00000052126 E054 0.9350151 0.3086913583 1.000000e+00 1.000000e+00 12 19370722 19373668 2947 + 0.248 0.229 -0.145
ENSG00000052126 E055 57.9868215 0.0156259710 5.743501e-11 1.055270e-09 12 19375531 19376400 870 + 1.530 2.013 1.635