ENSG00000051596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265097 ENSG00000051596 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC3 protein_coding protein_coding 135.128 159.0526 124.1908 32.13156 1.396043 -0.356921 117.091242 128.76010 111.400038 24.140995 2.5315836 -0.2089184 0.8676083 0.81386667 0.89680000 0.08293333 0.03015345 0.03015345 FALSE  
ENST00000432305 ENSG00000051596 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC3 protein_coding protein_coding 135.128 159.0526 124.1908 32.13156 1.396043 -0.356921 9.215019 11.21793 7.213211 1.514306 0.3583668 -0.6363803 0.0687375 0.07323333 0.05813333 -0.01510000 0.42272825 0.03015345 FALSE  
ENST00000514861 ENSG00000051596 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC3 protein_coding protein_coding 135.128 159.0526 124.1908 32.13156 1.396043 -0.356921 4.509877 15.87457 1.704868 7.503656 1.7048677 -3.2114572 0.0303250 0.09136667 0.01393333 -0.07743333 0.07441692 0.03015345 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000051596 E001 0.5943067 0.0198327708 0.1389594591 0.2466639118 5 175917845 175917872 28 - 0.353 0.098 -2.311
ENSG00000051596 E002 72.2257608 0.0003588183 0.5473226976 0.6773847803 5 175917873 175918172 300 - 1.838 1.857 0.067
ENSG00000051596 E003 0.0000000       5 175926559 175926741 183 -      
ENSG00000051596 E004 1.6177105 0.0401820897 0.6232354811 0.7398697773 5 175940444 175940530 87 - 0.353 0.441 0.490
ENSG00000051596 E005 1.8507959 0.0082141369 0.1593103857 0.2742040137 5 175959531 175959532 2 - 0.264 0.515 1.442
ENSG00000051596 E006 28.9019222 0.0245431599 0.2758586187 0.4152510288 5 175959533 175959590 58 - 1.395 1.489 0.324
ENSG00000051596 E007 60.7393040 0.0004297595 0.0152304650 0.0410080287 5 175959591 175959627 37 - 1.702 1.812 0.372
ENSG00000051596 E008 225.2144699 0.0002202589 0.0003367981 0.0015275805 5 175959628 175959882 255 - 2.285 2.368 0.276
ENSG00000051596 E009 868.1422664 0.0007673540 0.0009718452 0.0038625676 5 175959883 175960132 250 - 2.895 2.935 0.133
ENSG00000051596 E010 5.2151091 0.0182663049 0.3993224618 0.5430561891 5 175960219 175961050 832 - 0.862 0.742 -0.474
ENSG00000051596 E011 435.9773325 0.0001697267 0.5202752661 0.6542510867 5 175961051 175961080 30 - 2.624 2.629 0.016
ENSG00000051596 E012 327.0460951 0.0001941608 0.4992130142 0.6355379874 5 175961081 175961141 61 - 2.498 2.505 0.024
ENSG00000051596 E013 170.0834699 0.0002187605 0.2803712234 0.4202374096 5 175961142 175961151 10 - 2.203 2.227 0.080
ENSG00000051596 E014 224.1531690 0.0017201813 0.2783181531 0.4179868972 5 175961273 175961364 92 - 2.321 2.344 0.077
ENSG00000051596 E015 69.5872206 0.0061354526 0.7891141904 0.8650035038 5 175961365 175961419 55 - 1.848 1.828 -0.066
ENSG00000051596 E016 37.9934954 0.0005993788 0.4975858343 0.6341216745 5 175961420 175961434 15 - 1.558 1.593 0.118
ENSG00000051596 E017 81.9722775 0.0055274982 0.0402109212 0.0914232031 5 175964951 175965155 205 - 1.978 1.857 -0.406
ENSG00000051596 E018 1.6627394 0.0101654874 0.0215233202 0.0546900819 5 175965156 175965268 113 - 0.638 0.245 -2.142
ENSG00000051596 E019 258.5436695 0.0001680804 0.0001771045 0.0008658336 5 175967111 175967267 157 - 2.458 2.369 -0.296
ENSG00000051596 E020 0.0000000       5 175967471 175967544 74 -      
ENSG00000051596 E021 159.6211365 0.0002634908 0.0024353105 0.0085677037 5 175967942 175967945 4 - 2.253 2.161 -0.306
ENSG00000051596 E022 756.6407505 0.0052071900 0.0511052430 0.1111393298 5 175967946 175968315 370 - 2.913 2.824 -0.295
ENSG00000051596 E023 0.0000000       5 176007002 176007141 140 -      
ENSG00000051596 E024 0.0000000       5 176011009 176011099 91 -      
ENSG00000051596 E025 0.0000000       5 176034566 176034680 115 -