ENSG00000051382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000469284 ENSG00000051382 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CB protein_coding nonsense_mediated_decay 6.261963 3.752508 8.070625 0.08513159 0.1653643 1.102772 0.4809906 1.30363657 0.0000000 0.17816085 0.0000000 -7.037422 0.12060833 0.34986667 0.00000000 -0.3498667 2.685566e-18 2.685566e-18 FALSE TRUE
ENST00000477593 ENSG00000051382 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CB protein_coding protein_coding 6.261963 3.752508 8.070625 0.08513159 0.1653643 1.102772 3.5991571 1.76856905 4.9835420 0.05958933 0.2637122 1.489347 0.57003333 0.47110000 0.61710000 0.1460000 2.939354e-02 2.685566e-18 FALSE TRUE
ENST00000493568 ENSG00000051382 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CB protein_coding protein_coding 6.261963 3.752508 8.070625 0.08513159 0.1653643 1.102772 0.3610949 0.05951509 0.5746439 0.05951509 0.3440741 3.072160 0.04382917 0.01606667 0.07076667 0.0547000 6.503064e-01 2.685566e-18 FALSE TRUE
MSTRG.23786.9 ENSG00000051382 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CB protein_coding   6.261963 3.752508 8.070625 0.08513159 0.1653643 1.102772 1.2913898 0.39983434 1.9306009 0.23098958 0.1659103 2.243391 0.17250833 0.10400000 0.24026667 0.1362667 4.477446e-01 2.685566e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000051382 E001 0.0000000       3 138652698 138652698 1 -      
ENSG00000051382 E002 3.0333863 0.0055469144 0.2388133023 0.372758207 3 138652699 138654017 1319 - 0.649 0.471 -0.818
ENSG00000051382 E003 0.8900644 0.0590419265 0.0738795119 0.149713349 3 138654018 138654019 2 - 0.361 0.000 -12.233
ENSG00000051382 E004 1.1115096 0.0546419424 0.3146497500 0.457383744 3 138654020 138654021 2 - 0.361 0.174 -1.397
ENSG00000051382 E005 3.0719787 0.0056585032 0.3587461578 0.503116580 3 138654022 138654067 46 - 0.528 0.692 0.723
ENSG00000051382 E006 145.1322784 0.0336202536 0.0013950381 0.005290583 3 138654068 138655087 1020 - 2.010 2.321 1.039
ENSG00000051382 E007 39.8410272 0.0009430590 0.0105502162 0.030091432 3 138655088 138655149 62 - 1.524 1.695 0.583
ENSG00000051382 E008 61.0239200 0.0005394457 0.0332726257 0.078334234 3 138655150 138655311 162 - 1.725 1.849 0.420
ENSG00000051382 E009 64.8678106 0.0003733556 0.0340787192 0.079910277 3 138655312 138655526 215 - 1.752 1.872 0.406
ENSG00000051382 E010 47.8306334 0.0004908905 0.3730963308 0.517532349 3 138656142 138656274 133 - 1.639 1.712 0.248
ENSG00000051382 E011 0.0000000       3 138657283 138657689 407 -      
ENSG00000051382 E012 52.4492329 0.0004917323 0.3663845098 0.510725571 3 138657690 138657835 146 - 1.676 1.748 0.243
ENSG00000051382 E013 45.6128764 0.0005310757 0.3975933665 0.541342837 3 138663906 138664029 124 - 1.619 1.691 0.243
ENSG00000051382 E014 45.3808178 0.0005195993 0.2390281177 0.372983327 3 138665036 138665203 168 - 1.610 1.699 0.303
ENSG00000051382 E015 24.7589373 0.0026799093 0.8586180389 0.912788779 3 138681967 138681983 17 - 1.378 1.391 0.043
ENSG00000051382 E016 35.1902831 0.0212426869 0.2621892812 0.399943418 3 138681984 138682045 62 - 1.480 1.614 0.460
ENSG00000051382 E017 0.3666179 0.0292636510 0.5774567059 0.702711609 3 138682046 138682060 15 - 0.085 0.174 1.186
ENSG00000051382 E018 38.8982893 0.0007043529 0.2152386549 0.344706090 3 138683678 138683787 110 - 1.538 1.635 0.334
ENSG00000051382 E019 38.4079961 0.0005210959 0.2695484707 0.408042998 3 138684625 138684803 179 - 1.540 1.630 0.307
ENSG00000051382 E020 0.1451727 0.0426731671 1.0000000000   3 138684804 138685126 323 - 0.085 0.000 -9.647
ENSG00000051382 E021 29.7483545 0.0006535671 0.7161050272 0.811838816 3 138688875 138688974 100 - 1.467 1.469 0.007
ENSG00000051382 E022 24.8533240 0.0013689433 0.2533296872 0.389837861 3 138691000 138691062 63 - 1.412 1.354 -0.203
ENSG00000051382 E023 28.0590663 0.0007167641 0.0633316447 0.132248604 3 138691063 138691143 81 - 1.476 1.372 -0.360
ENSG00000051382 E024 33.4361884 0.0036804129 0.2491399383 0.384900542 3 138694786 138694907 122 - 1.535 1.483 -0.178
ENSG00000051382 E025 44.1538235 0.0156663331 0.1162817666 0.214655466 3 138698907 138699095 189 - 1.667 1.570 -0.329
ENSG00000051382 E026 19.2450737 0.0250920290 0.1480108254 0.258971784 3 138704443 138704493 51 - 1.329 1.184 -0.510
ENSG00000051382 E027 33.4326615 0.0006687067 0.5236451501 0.657278227 3 138707159 138707289 131 - 1.518 1.504 -0.049
ENSG00000051382 E028 0.2966881 0.0290785164 0.4991630395   3 138707290 138707621 332 - 0.156 0.000 -10.648
ENSG00000051382 E029 34.2604157 0.0143440345 0.4593485091 0.599530479 3 138712208 138712304 97 - 1.539 1.499 -0.140
ENSG00000051382 E030 47.6289336 0.0119895517 0.0688690375 0.141496789 3 138714468 138714659 192 - 1.702 1.589 -0.384
ENSG00000051382 E031 27.8683737 0.0061082420 0.2421996707 0.376792221 3 138714660 138714719 60 - 1.463 1.398 -0.224
ENSG00000051382 E032 28.9421817 0.0084745588 0.0702484483 0.143773108 3 138733361 138733438 78 - 1.494 1.373 -0.420
ENSG00000051382 E033 42.5810785 0.0080591605 0.0961163359 0.184543949 3 138734634 138734804 171 - 1.649 1.559 -0.307
ENSG00000051382 E034 40.2432251 0.0030504706 0.0125395623 0.034826970 3 138737707 138737886 180 - 1.637 1.504 -0.455
ENSG00000051382 E035 39.9427045 0.0009742624 0.0004965515 0.002146839 3 138742558 138742755 198 - 1.650 1.462 -0.643
ENSG00000051382 E036 17.2196135 0.0010612051 0.0814076945 0.161762571 3 138742756 138742781 26 - 1.282 1.153 -0.455
ENSG00000051382 E037 14.2419033 0.0015731713 0.0570542492 0.121557331 3 138755754 138755756 3 - 1.213 1.053 -0.575
ENSG00000051382 E038 45.7730661 0.0048540279 0.0003841617 0.001713478 3 138755757 138755979 223 - 1.712 1.503 -0.711
ENSG00000051382 E039 13.1100452 0.0039588072 0.0219434825 0.055556509 3 138759173 138759174 2 - 1.190 0.971 -0.794
ENSG00000051382 E040 33.3887495 0.0006317904 0.0332442297 0.078281000 3 138759175 138759359 185 - 1.551 1.439 -0.384
ENSG00000051382 E041 0.9201516 0.0146289428 0.3663541433 0.510692872 3 138770051 138770117 67 - 0.217 0.392 1.181
ENSG00000051382 E042 0.0000000       3 138770118 138770555 438 -      
ENSG00000051382 E043 19.0025189 0.0009676010 0.1183169185 0.217524239 3 138796463 138796567 105 - 1.315 1.210 -0.371
ENSG00000051382 E044 10.5012793 0.0015953658 0.0390860841 0.089352259 3 138834695 138834928 234 - 1.103 0.896 -0.765