ENSG00000050405

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341247 ENSG00000050405 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMA1 protein_coding protein_coding 9.661821 4.200756 12.9959 0.2559475 0.2103232 1.627015 5.4584021 1.3986921 7.5256454 0.2490179 0.5338535 2.419375 0.4929667 0.3289000 0.58050000 0.25160000 1.467255e-02 1.090723e-23 FALSE TRUE
ENST00000552491 ENSG00000050405 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMA1 protein_coding protein_coding 9.661821 4.200756 12.9959 0.2559475 0.2103232 1.627015 0.6919771 1.6784061 0.0000000 0.3382198 0.0000000 -7.399518 0.1587333 0.3930667 0.00000000 -0.39306667 1.090723e-23 1.090723e-23 FALSE TRUE
ENST00000552783 ENSG00000050405 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMA1 protein_coding protein_coding 9.661821 4.200756 12.9959 0.2559475 0.2103232 1.627015 2.0555395 0.8196282 3.3541819 0.3548446 0.3121924 2.019719 0.2066708 0.2072333 0.25790000 0.05066667 7.309455e-01 1.090723e-23 FALSE TRUE
ENST00000552823 ENSG00000050405 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMA1 protein_coding protein_coding 9.661821 4.200756 12.9959 0.2559475 0.2103232 1.627015 0.9808531 0.2754912 0.6293569 0.2754912 0.6293569 1.163175 0.1047458 0.0645000 0.04706667 -0.01743333 9.090493e-01 1.090723e-23 FALSE TRUE
MSTRG.7274.7 ENSG00000050405 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMA1 protein_coding   9.661821 4.200756 12.9959 0.2559475 0.2103232 1.627015 0.3441834 0.0000000 1.0790039 0.0000000 0.5856372 6.766865 0.0232875 0.0000000 0.08396667 0.08396667 3.355886e-01 1.090723e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000050405 E001 0.0000000       12 50175788 50175789 2 -      
ENSG00000050405 E002 231.8896936 0.0035564085 3.398933e-22 2.761225e-20 12 50175790 50176884 1095 - 2.194 2.534 1.131
ENSG00000050405 E003 30.3732888 0.0006626124 8.421066e-03 2.484095e-02 12 50176885 50176896 12 - 1.376 1.581 0.704
ENSG00000050405 E004 59.1600973 0.0004097863 4.767022e-02 1.050297e-01 12 50176897 50177005 109 - 1.686 1.812 0.428
ENSG00000050405 E005 218.1574885 0.0001823636 9.608146e-01 9.793262e-01 12 50177006 50177697 692 - 2.275 2.305 0.100
ENSG00000050405 E006 49.8741824 0.0005447572 8.852097e-01 9.306076e-01 12 50177698 50177773 76 - 1.643 1.663 0.068
ENSG00000050405 E007 94.3977043 0.0011025769 3.596207e-02 8.350685e-02 12 50177774 50178069 296 - 1.937 1.873 -0.214
ENSG00000050405 E008 53.6211782 0.0004523600 2.611352e-03 9.099003e-03 12 50181904 50182034 131 - 1.713 1.567 -0.496
ENSG00000050405 E009 20.9300488 0.0009416879 1.729569e-01 2.920388e-01 12 50182035 50182037 3 - 1.304 1.210 -0.330
ENSG00000050405 E010 0.0000000       12 50182038 50182179 142 -      
ENSG00000050405 E011 0.2214452 0.0390866982 1.371830e-01   12 50185390 50185448 59 - 0.000 0.207 11.816
ENSG00000050405 E012 49.5814386 0.0004740549 1.959350e-01 3.211457e-01 12 50192452 50192561 110 - 1.655 1.608 -0.159
ENSG00000050405 E013 4.9494881 0.1543084406 3.251271e-01 4.685514e-01 12 50192562 50192564 3 - 0.771 0.540 -0.988
ENSG00000050405 E014 0.2987644 0.0271250008 8.136554e-01   12 50195618 50195829 212 - 0.130 0.000 -11.147
ENSG00000050405 E015 35.7044615 0.0047318985 1.999947e-01 3.262444e-01 12 50195830 50195887 58 - 1.523 1.453 -0.240
ENSG00000050405 E016 0.0000000       12 50195978 50196047 70 -      
ENSG00000050405 E017 41.5153123 0.0005328125 1.156024e-01 2.136970e-01 12 50200777 50200884 108 - 1.586 1.514 -0.247
ENSG00000050405 E018 0.1515154 0.0430427535 1.000000e+00   12 50200885 50201302 418 - 0.070 0.000 -9.931
ENSG00000050405 E019 0.1482932 0.0411701238 1.386671e-01   12 50201303 50201324 22 - 0.000 0.206 11.776
ENSG00000050405 E020 0.5953508 0.0244219030 2.573836e-01 3.944927e-01 12 50201325 50202112 788 - 0.130 0.345 1.802
ENSG00000050405 E021 0.1451727 0.0431225592 1.000000e+00   12 50204344 50204551 208 - 0.070 0.000 -9.929
ENSG00000050405 E022 50.6986507 0.0052097637 8.142137e-02 1.617829e-01 12 50204552 50204700 149 - 1.675 1.583 -0.311
ENSG00000050405 E023 47.9440774 0.0004959563 7.873415e-03 2.346160e-02 12 50205984 50206068 85 - 1.663 1.530 -0.455
ENSG00000050405 E024 0.0000000       12 50220523 50220556 34 -      
ENSG00000050405 E025 55.7797910 0.0042174490 1.428401e-01 2.519072e-01 12 50222021 50222166 146 - 1.714 1.651 -0.215
ENSG00000050405 E026 35.5788023 0.0208984357 8.952237e-02 1.744004e-01 12 50222167 50222208 42 - 1.540 1.393 -0.505
ENSG00000050405 E027 40.1036981 0.0006117426 1.954865e-02 5.051611e-02 12 50222209 50222259 51 - 1.588 1.462 -0.432
ENSG00000050405 E028 40.1465656 0.0005336584 2.982110e-03 1.021059e-02 12 50222260 50222317 58 - 1.596 1.424 -0.589
ENSG00000050405 E029 60.8775962 0.0004453848 6.429488e-05 3.524238e-04 12 50222318 50222485 168 - 1.775 1.581 -0.659
ENSG00000050405 E030 13.6357159 0.0596506385 7.665759e-01 8.490417e-01 12 50222486 50222705 220 - 1.114 1.101 -0.045
ENSG00000050405 E031 0.0000000       12 50224258 50224481 224 -      
ENSG00000050405 E032 22.1785971 0.0016023635 3.300926e-03 1.115164e-02 12 50231665 50231710 46 - 1.364 1.119 -0.861
ENSG00000050405 E033 30.6399100 0.0013968325 3.010406e-03 1.029686e-02 12 50248633 50248774 142 - 1.490 1.285 -0.713
ENSG00000050405 E034 0.0000000       12 50249683 50249786 104 -      
ENSG00000050405 E035 0.0000000       12 50249787 50249893 107 -      
ENSG00000050405 E036 15.7887423 0.0025958924 9.296177e-02 1.797626e-01 12 50283420 50283529 110 - 1.203 1.055 -0.532