ENSG00000050393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379170 ENSG00000050393 HEK293_OSMI2_2hA HEK293_TMG_2hB MCUR1 protein_coding protein_coding 24.58082 24.79895 30.33062 0.08248509 1.528641 0.2903903 5.855125 3.621406 10.186118 0.3582913 0.3494663 1.4894196 0.2265875 0.1460333 0.33690000 0.19086667 4.602464e-08 4.602464e-08 FALSE TRUE
ENST00000607303 ENSG00000050393 HEK293_OSMI2_2hA HEK293_TMG_2hB MCUR1 protein_coding protein_coding 24.58082 24.79895 30.33062 0.08248509 1.528641 0.2903903 8.334632 8.565608 9.473786 0.7116377 1.6807779 0.1452242 0.3315625 0.3452333 0.30903333 -0.03620000 7.891022e-01 4.602464e-08 FALSE TRUE
MSTRG.27669.11 ENSG00000050393 HEK293_OSMI2_2hA HEK293_TMG_2hB MCUR1 protein_coding   24.58082 24.79895 30.33062 0.08248509 1.528641 0.2903903 5.204652 3.736955 6.314628 2.1736971 0.4084851 0.7552619 0.2065208 0.1508667 0.20863333 0.05776667 7.899357e-01 4.602464e-08 FALSE TRUE
MSTRG.27669.13 ENSG00000050393 HEK293_OSMI2_2hA HEK293_TMG_2hB MCUR1 protein_coding   24.58082 24.79895 30.33062 0.08248509 1.528641 0.2903903 2.237087 4.491185 1.456358 2.4612870 0.1216063 -1.6180675 0.1018417 0.1810000 0.04813333 -0.13286667 8.528520e-01 4.602464e-08 FALSE TRUE
MSTRG.27669.4 ENSG00000050393 HEK293_OSMI2_2hA HEK293_TMG_2hB MCUR1 protein_coding   24.58082 24.79895 30.33062 0.08248509 1.528641 0.2903903 2.675518 4.124479 2.606444 0.7085307 0.4216719 -0.6600982 0.1221167 0.1664333 0.08773333 -0.07870000 1.959645e-01 4.602464e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000050393 E001 0.3299976 0.0274424043 1.200688e-01   6 13712421 13712541 121 - 0.000 0.246 9.981
ENSG00000050393 E002 63.6698260 0.0385889292 1.926541e-01 3.170960e-01 6 13786557 13787049 493 - 1.737 1.884 0.494
ENSG00000050393 E003 55.8073853 0.0206604313 6.657137e-01 7.733539e-01 6 13787050 13787097 48 - 1.774 1.737 -0.124
ENSG00000050393 E004 62.5374363 0.0233414848 2.124382e-01 3.414074e-01 6 13787098 13787133 36 - 1.850 1.744 -0.357
ENSG00000050393 E005 55.9880157 0.0043863161 3.445781e-02 8.063552e-02 6 13787134 13787144 11 - 1.813 1.681 -0.447
ENSG00000050393 E006 68.1750993 0.0078027481 1.164130e-02 3.267902e-02 6 13787145 13787171 27 - 1.909 1.747 -0.547
ENSG00000050393 E007 125.9092309 0.0042686679 8.637850e-03 2.537943e-02 6 13787172 13787355 184 - 2.157 2.029 -0.430
ENSG00000050393 E008 242.4779585 0.0061550496 2.313246e-04 1.097129e-03 6 13787356 13788226 871 - 2.456 2.287 -0.562
ENSG00000050393 E009 96.3810210 0.0150213722 1.253416e-02 3.481351e-02 6 13788227 13788550 324 - 2.068 1.872 -0.659
ENSG00000050393 E010 41.4760712 0.0047223284 1.042432e-02 2.980419e-02 6 13788551 13788645 95 - 1.702 1.520 -0.619
ENSG00000050393 E011 38.5456402 0.0005800322 3.654239e-04 1.640407e-03 6 13788646 13788704 59 - 1.685 1.461 -0.763
ENSG00000050393 E012 200.4842275 0.0020583025 3.738928e-26 4.514523e-24 6 13788705 13789951 1247 - 2.441 2.064 -1.260
ENSG00000050393 E013 114.7929955 0.0002397043 5.449395e-38 1.651794e-35 6 13789952 13790571 620 - 2.228 1.740 -1.639
ENSG00000050393 E014 12.9945695 0.0014019495 9.752656e-03 2.815536e-02 6 13790572 13790640 69 - 1.253 0.991 -0.943
ENSG00000050393 E015 26.4021038 0.0006946073 5.246230e-05 2.940767e-04 6 13790641 13790787 147 - 1.552 1.251 -1.042
ENSG00000050393 E016 102.7248625 0.0006616878 3.547106e-06 2.612404e-05 6 13790788 13790864 77 - 1.942 2.093 0.508
ENSG00000050393 E017 240.3487140 0.0002106661 3.206208e-16 1.295110e-14 6 13791878 13791992 115 - 2.295 2.466 0.570
ENSG00000050393 E018 253.3151400 0.0001757387 5.331384e-16 2.087239e-14 6 13793894 13793947 54 - 2.321 2.484 0.545
ENSG00000050393 E019 316.1516464 0.0002489519 4.793879e-10 7.529940e-09 6 13798833 13798904 72 - 2.445 2.555 0.365
ENSG00000050393 E020 262.2729648 0.0002312654 1.329864e-06 1.075604e-05 6 13800341 13800382 42 - 2.374 2.465 0.302
ENSG00000050393 E021 333.0675316 0.0016856825 1.120193e-03 4.371108e-03 6 13801288 13801389 102 - 2.490 2.557 0.225
ENSG00000050393 E022 320.4818102 0.0003661219 1.556871e-02 4.177625e-02 6 13802243 13802346 104 - 2.489 2.523 0.112
ENSG00000050393 E023 0.3686942 0.0321131764 7.927286e-01 8.674828e-01 6 13803730 13804315 586 - 0.106 0.141 0.468
ENSG00000050393 E024 236.0535595 0.0016893147 5.187724e-01 6.529791e-01 6 13806925 13807044 120 - 2.371 2.373 0.009
ENSG00000050393 E025 2.9871734 0.0052677443 7.043282e-01 8.028924e-01 6 13810422 13810498 77 - 0.636 0.565 -0.313
ENSG00000050393 E026 8.0385002 0.0035383919 4.756907e-01 6.143861e-01 6 13810499 13810600 102 - 0.994 0.897 -0.365
ENSG00000050393 E027 0.0000000       6 13810601 13810602 2 -      
ENSG00000050393 E028 200.5949625 0.0092139587 7.251097e-01 8.184426e-01 6 13814015 13815400 1386 - 2.318 2.283 -0.116