ENSG00000049883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308077 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 1.04252755 0.2664864 1.7533038 0.150021485 0.09678750 2.6730005 0.29864167 0.1620667 0.31973333 0.15766667 4.548793e-01 1.979166e-07 TRUE TRUE
ENST00000380639 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding protein_coding 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 0.30496808 0.3065358 0.2157630 0.182091584 0.09432840 -0.4875593 0.14186667 0.2291667 0.03980000 -0.18936667 5.928750e-01 1.979166e-07 FALSE TRUE
ENST00000486995 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 0.08780747 0.1069150 0.1209627 0.005523236 0.01611233 0.1636954 0.03267083 0.0730000 0.02213333 -0.05086667 1.610707e-01 1.979166e-07 FALSE TRUE
ENST00000503315 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 0.02006841 0.1605473 0.0000000 0.160547307 0.00000000 -4.0921001 0.01493750 0.1195000 0.00000000 -0.11950000 5.987246e-01 1.979166e-07 FALSE TRUE
ENST00000511752 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding nonsense_mediated_decay 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 0.41864824 0.0000000 1.2036632 0.000000000 0.15704728 6.9232243 0.08278750 0.0000000 0.22030000 0.22030000 1.979166e-07 1.979166e-07 FALSE FALSE
ENST00000543322 ENSG00000049883 HEK293_OSMI2_2hA HEK293_TMG_2hB PTCD2 protein_coding protein_coding 3.494894 1.51614 5.484072 0.1769275 0.09108864 1.847988 1.23866815 0.5841994 1.6641103 0.335957743 0.28765522 1.4943756 0.33883750 0.3544667 0.30333333 -0.05113333 1.000000e+00 1.979166e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049883 E001 0.3332198 0.0309822000 4.914739e-01   5 72320367 72320367 1 + 0.081 0.181 1.328
ENSG00000049883 E002 0.3332198 0.0309822000 4.914739e-01   5 72320368 72320372 5 + 0.081 0.181 1.328
ENSG00000049883 E003 0.3332198 0.0309822000 4.914739e-01   5 72320373 72320375 3 + 0.081 0.181 1.328
ENSG00000049883 E004 0.4815130 0.0206871942 1.703346e-01 2.886039e-01 5 72320376 72320384 9 + 0.081 0.308 2.326
ENSG00000049883 E005 0.7029582 0.0172671820 5.466168e-02 1.174065e-01 5 72320385 72320387 3 + 0.081 0.406 2.913
ENSG00000049883 E006 4.5255545 0.0207217547 9.524438e-01 9.742168e-01 5 72320388 72320397 10 + 0.725 0.710 -0.064
ENSG00000049883 E007 4.5255545 0.0207217547 9.524438e-01 9.742168e-01 5 72320398 72320398 1 + 0.725 0.710 -0.064
ENSG00000049883 E008 12.1489281 0.0496296689 5.957241e-01 7.177809e-01 5 72320399 72320509 111 + 1.124 1.046 -0.281
ENSG00000049883 E009 0.5911862 0.0172671820 2.213613e-01 3.520592e-01 5 72320510 72321179 670 + 0.260 0.000 -13.144
ENSG00000049883 E010 0.4417471 0.7097638165 6.776608e-01 7.823232e-01 5 72321321 72321376 56 + 0.208 0.000 -12.662
ENSG00000049883 E011 17.2413897 0.0430084020 3.847015e-02 8.823097e-02 5 72322172 72322264 93 + 1.312 1.044 -0.953
ENSG00000049883 E012 24.4394475 0.0008972290 7.670549e-02 1.542243e-01 5 72326612 72326741 130 + 1.423 1.280 -0.498
ENSG00000049883 E013 27.3928444 0.0009236485 1.436047e-01 2.529186e-01 5 72331258 72331375 118 + 1.458 1.345 -0.392
ENSG00000049883 E014 19.6864799 0.0012214117 2.492035e-01 3.849736e-01 5 72335018 72335096 79 + 1.321 1.216 -0.366
ENSG00000049883 E015 0.0000000       5 72335559 72335793 235 +      
ENSG00000049883 E016 23.8170348 0.0008502811 6.131813e-01 7.319486e-01 5 72335794 72335885 92 + 1.380 1.335 -0.158
ENSG00000049883 E017 26.9900546 0.0007270006 5.256921e-01 6.590363e-01 5 72338622 72338735 114 + 1.436 1.384 -0.181
ENSG00000049883 E018 18.5921797 0.0010356013 8.060621e-01 8.767089e-01 5 72342962 72343036 75 + 1.271 1.243 -0.098
ENSG00000049883 E019 20.8028140 0.0015345106 6.783622e-01 7.828610e-01 5 72352641 72352754 114 + 1.299 1.325 0.090
ENSG00000049883 E020 0.0000000       5 72352755 72352757 3 +      
ENSG00000049883 E021 36.5475725 0.0007445147 9.070160e-01 9.449997e-01 5 72358203 72358470 268 + 1.550 1.551 0.000
ENSG00000049883 E022 40.8758911 0.0007534943 5.653981e-01 6.925035e-01 5 72358471 72358725 255 + 1.589 1.615 0.088
ENSG00000049883 E023 29.5337423 0.0016917885 2.062769e-01 3.340532e-01 5 72358726 72358823 98 + 1.433 1.511 0.268
ENSG00000049883 E024 34.9391214 0.0017839478 1.218049e-06 9.930961e-06 5 72358824 72359603 780 + 1.413 1.699 0.978
ENSG00000049883 E025 283.8689549 0.0167348867 9.744302e-01 9.880318e-01 5 72359604 72368395 8792 + 2.430 2.418 -0.040