ENSG00000049860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261416 ENSG00000049860 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXB protein_coding protein_coding 42.88272 29.42634 53.11877 3.491029 1.032653 0.8518952 29.590202 16.182882 40.123202 1.1750089 1.7035431 1.309437 0.66239167 0.5557333 0.75470000 0.1989667 3.291602e-05 5.884991e-07 FALSE TRUE
MSTRG.26397.2 ENSG00000049860 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXB protein_coding   42.88272 29.42634 53.11877 3.491029 1.032653 0.8518952 3.045282 1.319888 4.496381 0.1767663 0.5952230 1.760665 0.06897083 0.0468000 0.08470000 0.0379000 1.448702e-01 5.884991e-07 FALSE TRUE
MSTRG.26397.9 ENSG00000049860 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXB protein_coding   42.88272 29.42634 53.11877 3.491029 1.032653 0.8518952 6.366555 8.811175 3.777210 1.6429097 0.6586404 -1.219835 0.17084167 0.2956333 0.07146667 -0.2241667 5.884991e-07 5.884991e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049860 E001 0.7708142 0.0142324950 3.934191e-01 5.373114e-01 5 74640023 74640558 536 + 0.304 0.151 -1.285
ENSG00000049860 E002 0.8910940 0.2713358355 9.078767e-01 9.455411e-01 5 74684962 74685162 201 + 0.246 0.270 0.176
ENSG00000049860 E003 9.4381190 0.0027858482 8.871348e-04 3.569093e-03 5 74685163 74685195 33 + 1.137 0.747 -1.469
ENSG00000049860 E004 25.1888450 0.0008027075 3.559347e-02 8.279707e-02 5 74685196 74685205 10 + 1.469 1.322 -0.507
ENSG00000049860 E005 39.3950035 0.0006655848 5.203227e-03 1.648325e-02 5 74685206 74685232 27 + 1.662 1.503 -0.543
ENSG00000049860 E006 199.1876709 0.0020973735 8.413660e-06 5.685951e-05 5 74685233 74685559 327 + 2.355 2.202 -0.510
ENSG00000049860 E007 247.0462810 0.0002143581 4.830546e-13 1.246774e-11 5 74689328 74689473 146 + 2.455 2.286 -0.564
ENSG00000049860 E008 0.0000000       5 74689474 74689849 376 +      
ENSG00000049860 E009 0.0000000       5 74693475 74693638 164 +      
ENSG00000049860 E010 203.1867935 0.0002900262 1.231101e-03 4.745913e-03 5 74693639 74693704 66 + 2.339 2.259 -0.269
ENSG00000049860 E011 180.6671904 0.0002287179 5.522667e-01 6.815624e-01 5 74696693 74696739 47 + 2.262 2.250 -0.040
ENSG00000049860 E012 265.7271464 0.0001720261 3.162764e-02 7.512899e-02 5 74696996 74697106 111 + 2.442 2.398 -0.145
ENSG00000049860 E013 1.9657822 0.0086212803 9.883460e-01 9.967767e-01 5 74700753 74700797 45 + 0.482 0.489 0.034
ENSG00000049860 E014 1.8475632 0.0608302785 2.504069e-01 3.864199e-01 5 74700798 74700850 53 + 0.356 0.588 1.179
ENSG00000049860 E015 1.0579374 0.1419570011 6.863466e-01 7.888845e-01 5 74702493 74702536 44 + 0.355 0.262 -0.611
ENSG00000049860 E016 293.4938485 0.0009696240 2.810859e-03 9.707040e-03 5 74705219 74705320 102 + 2.495 2.420 -0.249
ENSG00000049860 E017 20.7544758 0.0009361969 7.149178e-03 2.161112e-02 5 74705321 74706168 848 + 1.243 1.448 0.714
ENSG00000049860 E018 201.2387463 0.0002455243 3.581801e-01 5.025488e-01 5 74713506 74713537 32 + 2.311 2.291 -0.066
ENSG00000049860 E019 294.9199268 0.0006250623 5.975829e-01 7.193161e-01 5 74713538 74713635 98 + 2.473 2.464 -0.030
ENSG00000049860 E020 252.0430278 0.0019146938 1.796619e-01 3.007334e-01 5 74715510 74715585 76 + 2.416 2.376 -0.134
ENSG00000049860 E021 235.7239172 0.0012042793 8.495636e-01 9.066453e-01 5 74715586 74715645 60 + 2.372 2.367 -0.016
ENSG00000049860 E022 208.8089594 0.0007049892 9.879284e-01 9.965020e-01 5 74715646 74715690 45 + 2.318 2.320 0.008
ENSG00000049860 E023 187.2792840 0.0001991115 2.690960e-01 4.075644e-01 5 74716587 74716628 42 + 2.259 2.292 0.111
ENSG00000049860 E024 209.0728723 0.0002817230 4.241631e-01 5.671441e-01 5 74716629 74716673 45 + 2.311 2.335 0.081
ENSG00000049860 E025 0.4355181 0.6198847463 4.511337e-01 5.921240e-01 5 74716674 74716829 156 + 0.245 0.000 -9.507
ENSG00000049860 E026 244.3117774 0.0002170019 3.238818e-02 7.660516e-02 5 74718291 74718363 73 + 2.365 2.419 0.180
ENSG00000049860 E027 300.0764077 0.0011331036 3.003613e-02 7.203089e-02 5 74718797 74718908 112 + 2.453 2.513 0.200
ENSG00000049860 E028 244.3131908 0.0071262257 4.212664e-01 5.644020e-01 5 74718909 74718971 63 + 2.370 2.412 0.141
ENSG00000049860 E029 12.4620981 0.0326859933 2.817782e-01 4.216957e-01 5 74719989 74720427 439 + 1.176 1.028 -0.532
ENSG00000049860 E030 285.4378094 0.0041789780 1.492455e-01 2.606389e-01 5 74720428 74720487 60 + 2.430 2.489 0.197
ENSG00000049860 E031 234.9062515 0.0019384808 1.029438e-02 2.949188e-02 5 74720488 74720518 31 + 2.336 2.420 0.281
ENSG00000049860 E032 318.7930913 0.0003701715 5.689100e-07 4.980513e-06 5 74720643 74720747 105 + 2.456 2.566 0.366
ENSG00000049860 E033 2.2871452 0.1386746642 2.671368e-01 4.054175e-01 5 74720748 74720836 89 + 0.402 0.664 1.246
ENSG00000049860 E034 1.3630420 0.0100998979 1.680735e-01 2.856902e-01 5 74721057 74721117 61 + 0.246 0.489 1.452
ENSG00000049860 E035 189.0833628 0.0001946345 3.047448e-10 4.953496e-09 5 74721118 74721317 200 + 2.201 2.368 0.557
ENSG00000049860 E036 1.2660437 0.0684443753 5.471652e-01 6.772430e-01 5 74721318 74721436 119 + 0.305 0.424 0.704
ENSG00000049860 E037 1.1040209 0.0118103380 6.015281e-01 7.226600e-01 5 74722299 74722468 170 + 0.356 0.263 -0.607
ENSG00000049860 E038 0.6569633 0.4697747438 8.345347e-01 8.964284e-01 5 74722469 74722647 179 + 0.245 0.155 -0.818