ENSG00000049656

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320895 ENSG00000049656 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPTM1L protein_coding protein_coding 202.1167 290.2745 136.5476 10.09167 2.572992 -1.087957 89.588178 122.02937 62.398856 9.418633 1.005226 -0.9675240 0.44665000 0.41980000 0.4571333 0.03733333 6.016531e-01 1.145408e-38 FALSE TRUE
ENST00000503534 ENSG00000049656 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPTM1L protein_coding retained_intron 202.1167 290.2745 136.5476 10.09167 2.572992 -1.087957 42.653470 80.53920 23.857376 7.045011 2.177101 -1.7548302 0.19929167 0.27800000 0.1742667 -0.10373333 2.083989e-02 1.145408e-38 FALSE TRUE
ENST00000507807 ENSG00000049656 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPTM1L protein_coding protein_coding 202.1167 290.2745 136.5476 10.09167 2.572992 -1.087957 12.842999 27.07076 0.000000 3.271757 0.000000 -11.4030527 0.05445000 0.09430000 0.0000000 -0.09430000 1.145408e-38 1.145408e-38 FALSE TRUE
ENST00000630539 ENSG00000049656 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPTM1L protein_coding protein_coding 202.1167 290.2745 136.5476 10.09167 2.572992 -1.087957 3.512953 0.00000 7.999591 0.000000 1.432525 9.6455847 0.02369167 0.00000000 0.0588000 0.05880000 3.799406e-33 1.145408e-38 FALSE TRUE
MSTRG.25881.9 ENSG00000049656 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPTM1L protein_coding   202.1167 290.2745 136.5476 10.09167 2.572992 -1.087957 22.200690 21.49990 19.928287 3.724346 1.835695 -0.1094591 0.11942917 0.07336667 0.1464333 0.07306667 1.393424e-02 1.145408e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049656 E001 2.2758052 0.0084481988 5.384586e-01 6.698847e-01 5 1317752 1317752 1 - 0.539 0.436 -0.510
ENSG00000049656 E002 116.9388134 0.0079424921 4.118366e-03 1.347400e-02 5 1317753 1317867 115 - 1.885 2.060 0.588
ENSG00000049656 E003 111.6689266 0.0047161860 5.407876e-04 2.312654e-03 5 1317868 1317869 2 - 1.856 2.043 0.628
ENSG00000049656 E004 219.8848690 0.0088557164 5.848654e-06 4.100248e-05 5 1317870 1317891 22 - 2.088 2.347 0.865
ENSG00000049656 E005 557.9842163 0.0029219287 5.059777e-05 2.848278e-04 5 1317892 1317959 68 - 2.591 2.727 0.451
ENSG00000049656 E006 1535.8119673 0.0019463162 3.731565e-07 3.385374e-06 5 1317960 1318174 215 - 3.037 3.163 0.418
ENSG00000049656 E007 1599.3781087 0.0011251079 1.085333e-05 7.152753e-05 5 1318175 1318298 124 - 3.083 3.172 0.296
ENSG00000049656 E008 1142.0012696 0.0004361911 9.042588e-05 4.770513e-04 5 1318299 1318354 56 - 2.954 3.020 0.218
ENSG00000049656 E009 1479.7366914 0.0013175926 4.301617e-01 5.728001e-01 5 1318355 1318453 99 - 3.099 3.122 0.074
ENSG00000049656 E010 40.5576029 0.0005295305 1.504120e-14 4.832956e-13 5 1320208 1320614 407 - 1.829 1.407 -1.435
ENSG00000049656 E011 13.7241654 0.0013003297 3.500906e-03 1.172790e-02 5 1320615 1320615 1 - 1.294 1.029 -0.947
ENSG00000049656 E012 798.2957575 0.0003377241 1.536784e-01 2.666707e-01 5 1320616 1320618 3 - 2.861 2.842 -0.061
ENSG00000049656 E013 1322.3582696 0.0003267011 9.548653e-01 9.756980e-01 5 1320619 1320683 65 - 3.063 3.069 0.020
ENSG00000049656 E014 1209.8212886 0.0010404491 7.207396e-01 8.153024e-01 5 1320684 1320731 48 - 3.020 3.032 0.042
ENSG00000049656 E015 811.2104448 0.0002888393 2.290524e-02 5.754391e-02 5 1321635 1321646 12 - 2.825 2.866 0.137
ENSG00000049656 E016 1099.8481656 0.0000711870 8.590963e-03 2.526596e-02 5 1321647 1321679 33 - 2.958 2.995 0.122
ENSG00000049656 E017 35.7070181 0.0006010356 3.473094e-01 4.915192e-01 5 1321680 1321763 84 - 1.549 1.494 -0.191
ENSG00000049656 E018 1242.6643575 0.0000718659 1.739186e-01 2.932862e-01 5 1321764 1321819 56 - 3.024 3.044 0.067
ENSG00000049656 E019 4.6842900 0.0096794325 1.120505e-01 2.085577e-01 5 1321820 1321829 10 - 0.869 0.647 -0.894
ENSG00000049656 E020 5.1338011 0.0576726103 2.385327e-02 5.950346e-02 5 1322834 1322876 43 - 0.971 0.606 -1.459
ENSG00000049656 E021 1118.4490009 0.0002405524 1.088587e-02 3.089443e-02 5 1322877 1322911 35 - 2.964 3.004 0.133
ENSG00000049656 E022 20.8973925 0.0172324556 9.313970e-01 9.607865e-01 5 1322912 1322915 4 - 1.295 1.292 -0.008
ENSG00000049656 E023 982.7089703 0.0001046082 7.784976e-04 3.181827e-03 5 1323787 1323832 46 - 2.900 2.950 0.164
ENSG00000049656 E024 1049.9997059 0.0001729458 4.911775e-01 6.284757e-01 5 1323833 1323869 37 - 2.955 2.969 0.046
ENSG00000049656 E025 16.5574770 0.0012027003 5.030154e-09 6.562096e-08 5 1323870 1324037 168 - 1.484 1.002 -1.705
ENSG00000049656 E026 1212.7036105 0.0003279229 1.260203e-01 2.286032e-01 5 1324763 1324813 51 - 3.008 3.035 0.088
ENSG00000049656 E027 71.5163687 0.0004917695 1.082619e-25 1.264482e-23 5 1324814 1325750 937 - 2.077 1.634 -1.495
ENSG00000049656 E028 1290.0985203 0.0002737581 3.257837e-01 4.692230e-01 5 1325751 1325816 66 - 3.042 3.060 0.059
ENSG00000049656 E029 5.0885473 0.0033357225 1.494547e-02 4.036345e-02 5 1325817 1325827 11 - 0.948 0.626 -1.284
ENSG00000049656 E030 10.8147463 0.0025879100 1.280341e-05 8.296793e-05 5 1326015 1326255 241 - 1.294 0.860 -1.581
ENSG00000049656 E031 10.7728910 0.0015653439 9.904224e-07 8.224087e-06 5 1326261 1326436 176 - 1.315 0.833 -1.758
ENSG00000049656 E032 1223.8074104 0.0017107153 4.821256e-01 6.202869e-01 5 1330280 1330383 104 - 3.017 3.039 0.074
ENSG00000049656 E033 14.2968966 0.0013254052 6.942554e-08 7.270569e-07 5 1330384 1330431 48 - 1.424 0.953 -1.682
ENSG00000049656 E034 61.8012470 0.0004052730 9.668232e-37 2.701501e-34 5 1330432 1331798 1367 - 2.074 1.506 -1.921
ENSG00000049656 E035 584.5981630 0.0030727560 4.642744e-01 6.040145e-01 5 1331799 1331802 4 - 2.691 2.720 0.096
ENSG00000049656 E036 1128.7490888 0.0003006795 8.325077e-01 8.950411e-01 5 1331803 1331883 81 - 2.996 2.998 0.006
ENSG00000049656 E037 0.3332198 0.0284396908 5.429803e-01   5 1332115 1332338 224 - 0.174 0.085 -1.192
ENSG00000049656 E038 953.1328132 0.0008692461 6.201697e-01 7.374496e-01 5 1334289 1334357 69 - 2.927 2.923 -0.013
ENSG00000049656 E039 716.9701376 0.0003832688 3.372859e-01 4.811582e-01 5 1334358 1334383 26 - 2.809 2.797 -0.040
ENSG00000049656 E040 1225.2811363 0.0005298857 6.161406e-02 1.293363e-01 5 1335057 1335174 118 - 3.050 3.027 -0.079
ENSG00000049656 E041 1026.7245691 0.0016557435 2.631989e-02 6.458839e-02 5 1337904 1337982 79 - 2.989 2.944 -0.149
ENSG00000049656 E042 2.8818538 0.0056078958 5.596060e-02 1.196295e-01 5 1337983 1338318 336 - 0.734 0.435 -1.360
ENSG00000049656 E043 1352.3514022 0.0005492833 1.436198e-04 7.192267e-04 5 1338860 1339002 143 - 3.114 3.062 -0.174
ENSG00000049656 E044 522.2267672 0.0005107876 1.230483e-03 4.743820e-03 5 1339003 1339005 3 - 2.707 2.647 -0.199
ENSG00000049656 E045 1460.2411328 0.0002305730 5.031407e-11 9.348697e-10 5 1341671 1341855 185 - 3.162 3.087 -0.248
ENSG00000049656 E046 502.8428983 0.0014660612 9.823922e-08 9.989869e-07 5 1341856 1341860 5 - 2.736 2.608 -0.426
ENSG00000049656 E047 907.8349085 0.0005389906 8.657283e-11 1.544929e-09 5 1344351 1344451 101 - 2.976 2.872 -0.343
ENSG00000049656 E048 655.2271381 0.0028761320 1.938639e-05 1.206654e-04 5 1344680 1345037 358 - 2.848 2.726 -0.404
ENSG00000049656 E049 36.0669539 0.1308249485 1.357025e-03 5.166485e-03 5 1345038 1345099 62 - 1.834 1.296 -1.842