ENSG00000049323

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000404525	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding	protein_coding	9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	0.1853515	0.8682889	0.0000000	0.45382519	0.0000000	-6.45662373	0.02549583	0.12170000	0.0000000	-0.12170000	0.10902738	0.00126945	FALSE	TRUE
ENST00000404816	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding	protein_coding	9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	1.0756938	0.1689266	1.8252140	0.15416513	0.2690193	3.35850825	0.10628750	0.02446667	0.1762000	0.15173333	0.03711532	0.00126945	FALSE	TRUE
ENST00000407925	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding	protein_coding	9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	3.0570122	3.3356968	3.4355787	0.30674625	0.3234582	0.04243961	0.34425833	0.46493333	0.3291667	-0.13576667	0.13956651	0.00126945	FALSE	TRUE
MSTRG.18186.2	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding		9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	0.2391800	0.0000000	0.5594666	0.00000000	0.2076662	5.83153921	0.02265833	0.00000000	0.0536000	0.05360000	0.00126945	0.00126945	FALSE	TRUE
MSTRG.18186.6	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding		9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	1.7766208	1.5390063	1.7296869	0.06189139	0.3809854	0.16748467	0.19588750	0.21646667	0.1670333	-0.04943333	0.65200104	0.00126945	FALSE	TRUE
MSTRG.18186.8	ENSG00000049323	HEK293_OSMI2_2hA	HEK293_TMG_2hB	LTBP1	protein_coding		9.337705	7.190015	10.41045	0.4260149	0.1836795	0.5333457	1.8635245	1.0845626	2.0569525	0.22851265	0.2275277	0.91715076	0.19992500	0.14833333	0.1984333	0.05010000	0.55500052	0.00126945	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 55
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000049323	E001	1.5157059	0.0158844326	3.106332e-02	7.403542e-02	2	32946819	32946952	134	+	0.528	0.147	-2.558
ENSG00000049323	E002	10.6928503	0.0374242071	3.205334e-03	1.087193e-02	2	32946953	32947437	485	+	1.190	0.800	-1.447
ENSG00000049323	E003	3.2119451	0.0047741099	1.336862e-03	5.099355e-03	2	32947438	32947489	52	+	0.778	0.256	-2.636
ENSG00000049323	E004	2.8819726	0.0156549267	4.160316e-03	1.359270e-02	2	32947490	32947510	21	+	0.738	0.256	-2.475
ENSG00000049323	E005	3.2182879	0.0047733662	1.336674e-03	5.098840e-03	2	32947511	32947552	42	+	0.778	0.256	-2.636
ENSG00000049323	E006	3.8094740	0.0040747292	2.104941e-04	1.008790e-03	2	32947553	32947577	25	+	0.849	0.256	-2.912
ENSG00000049323	E007	20.3338868	0.0114417193	7.597557e-05	4.089715e-04	2	32947578	32947818	241	+	1.445	1.091	-1.245
ENSG00000049323	E008	22.5901783	0.0018983119	1.272692e-04	6.468519e-04	2	32948875	32948945	71	+	1.469	1.201	-0.934
ENSG00000049323	E009	64.9560610	0.0003662506	1.555234e-08	1.849441e-07	2	33020909	33021206	298	+	1.902	1.675	-0.767
ENSG00000049323	E010	60.6290838	0.0004143235	5.518636e-08	5.891075e-07	2	33110582	33110751	170	+	1.870	1.644	-0.766
ENSG00000049323	E011	0.0000000				2	33134406	33134505	100	+
ENSG00000049323	E012	0.0000000				2	33134597	33134624	28	+
ENSG00000049323	E013	0.0000000				2	33134625	33134638	14	+
ENSG00000049323	E014	0.0000000				2	33134639	33134656	18	+
ENSG00000049323	E015	0.1817044	0.0394451842	3.488568e-01		2	33134657	33134792	136	+	0.000	0.147	10.384
ENSG00000049323	E016	53.9854573	0.0004163985	1.395369e-08	1.674575e-07	2	33134793	33134960	168	+	1.830	1.575	-0.863
ENSG00000049323	E017	70.3257999	0.0004513431	1.022283e-08	1.257996e-07	2	33186856	33187080	225	+	1.935	1.713	-0.747
ENSG00000049323	E018	88.1649428	0.0003045242	6.948936e-06	4.790070e-05	2	33188577	33188851	275	+	2.003	1.861	-0.479
ENSG00000049323	E019	48.4378871	0.0081561238	2.121883e-01	3.411070e-01	2	33217552	33217654	103	+	1.714	1.663	-0.175
ENSG00000049323	E020	36.4749352	0.0049638475	7.765643e-02	1.556983e-01	2	33222080	33222151	72	+	1.605	1.517	-0.300
ENSG00000049323	E021	43.9104326	0.0004969530	4.388505e-02	9.817314e-02	2	33243662	33243784	123	+	1.680	1.602	-0.264
ENSG00000049323	E022	38.7127042	0.0005602572	1.271341e-03	4.881663e-03	2	33252677	33252726	50	+	1.655	1.499	-0.532
ENSG00000049323	E023	56.0320363	0.0004606760	7.741093e-03	2.312769e-02	2	33252727	33252844	118	+	1.793	1.696	-0.327
ENSG00000049323	E024	26.7840431	0.0007306611	5.391644e-03	1.699185e-02	2	33257284	33257367	84	+	1.502	1.341	-0.558
ENSG00000049323	E025	29.5282139	0.0006691004	3.737986e-03	1.240476e-02	2	33257368	33257442	75	+	1.540	1.379	-0.555
ENSG00000049323	E026	48.9098853	0.0011838027	5.007945e-02	1.093019e-01	2	33257443	33257511	69	+	1.721	1.648	-0.247
ENSG00000049323	E027	34.4047988	0.0013288526	2.531469e-01	3.896262e-01	2	33259588	33259610	23	+	1.557	1.516	-0.138
ENSG00000049323	E028	56.0672842	0.0010599126	2.873583e-01	4.278637e-01	2	33262722	33262821	100	+	1.758	1.737	-0.073
ENSG00000049323	E029	0.4482035	0.0292875142	1.546310e-01	2.679152e-01	2	33262822	33262824	3	+	0.253	0.000	-11.021
ENSG00000049323	E030	57.0544461	0.0051809818	6.229588e-01	7.396584e-01	2	33263294	33263392	99	+	1.758	1.762	0.013
ENSG00000049323	E031	63.9179124	0.0006460858	8.165431e-03	2.420195e-02	2	33273656	33273781	126	+	1.845	1.755	-0.302
ENSG00000049323	E032	65.7732127	0.0004033809	6.317706e-02	1.320000e-01	2	33274965	33275090	126	+	1.842	1.791	-0.172
ENSG00000049323	E033	58.1520216	0.0004280891	9.332453e-02	1.803149e-01	2	33275801	33275908	108	+	1.787	1.740	-0.161
ENSG00000049323	E034	34.1820268	0.0005804443	3.639356e-02	8.433204e-02	2	33275909	33275923	15	+	1.584	1.488	-0.329
ENSG00000049323	E035	49.5073029	0.0032023076	9.313522e-01	9.607559e-01	2	33280039	33280158	120	+	1.689	1.717	0.092
ENSG00000049323	E036	0.0000000				2	33291484	33291787	304	+
ENSG00000049323	E037	69.1988643	0.0008080313	6.975309e-01	7.976456e-01	2	33293160	33293282	123	+	1.835	1.849	0.047
ENSG00000049323	E038	74.5726965	0.0027466876	8.550678e-01	9.103632e-01	2	33300451	33300573	123	+	1.864	1.887	0.078
ENSG00000049323	E039	36.2974606	0.0081051944	8.468819e-01	9.048504e-01	2	33301522	33301529	8	+	1.563	1.580	0.058
ENSG00000049323	E040	69.0055154	0.0004167558	8.822408e-01	9.286108e-01	2	33301530	33301631	102	+	1.832	1.856	0.082
ENSG00000049323	E041	35.5800867	0.0007758200	2.689864e-01	4.074542e-01	2	33301632	33301644	13	+	1.572	1.537	-0.122
ENSG00000049323	E042	65.7940394	0.0004012219	7.856846e-03	2.342107e-02	2	33309434	33309556	123	+	1.855	1.767	-0.294
ENSG00000049323	E043	67.3841708	0.0004008446	4.110467e-01	5.546417e-01	2	33315144	33315269	126	+	1.833	1.829	-0.016
ENSG00000049323	E044	0.0000000				2	33317698	33317940	243	+
ENSG00000049323	E045	58.9763650	0.0003891415	3.591652e-01	5.034984e-01	2	33342838	33342963	126	+	1.740	1.813	0.245
ENSG00000049323	E046	83.7969235	0.0003397778	1.220517e-01	2.228679e-01	2	33347367	33347510	144	+	1.882	1.973	0.304
ENSG00000049323	E047	31.8171425	0.0080682161	5.667723e-01	6.936613e-01	2	33360597	33360602	6	+	1.480	1.551	0.244
ENSG00000049323	E048	85.9075117	0.0036813577	2.152645e-01	3.447330e-01	2	33360603	33360779	177	+	1.896	1.985	0.300
ENSG00000049323	E049	66.3407612	0.0003798129	3.580403e-01	5.024420e-01	2	33361429	33361515	87	+	1.793	1.863	0.237
ENSG00000049323	E050	80.4320887	0.0009482634	5.349233e-03	1.688178e-02	2	33363390	33363518	129	+	1.833	1.979	0.489
ENSG00000049323	E051	86.5776749	0.0008928111	3.537218e-03	1.183238e-02	2	33364216	33364356	141	+	1.863	2.009	0.493
ENSG00000049323	E052	92.6848437	0.0007539993	3.330494e-04	1.512458e-03	2	33365333	33365503	171	+	1.883	2.050	0.562
ENSG00000049323	E053	89.4265908	0.0003631025	2.770245e-09	3.785722e-08	2	33389184	33389306	123	+	1.821	2.075	0.852
ENSG00000049323	E054	107.5551820	0.0033314740	4.807794e-06	3.437584e-05	2	33397133	33397282	150	+	1.917	2.145	0.764
ENSG00000049323	E055	324.1456612	0.0069316933	2.680195e-14	8.272318e-13	2	33398364	33399509	1146	+	2.322	2.669	1.156

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000049323

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3