ENSG00000049323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404525 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding protein_coding 9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 0.1853515 0.8682889 0.0000000 0.45382519 0.0000000 -6.45662373 0.02549583 0.12170000 0.0000000 -0.12170000 0.10902738 0.00126945 FALSE TRUE
ENST00000404816 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding protein_coding 9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 1.0756938 0.1689266 1.8252140 0.15416513 0.2690193 3.35850825 0.10628750 0.02446667 0.1762000 0.15173333 0.03711532 0.00126945 FALSE TRUE
ENST00000407925 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding protein_coding 9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 3.0570122 3.3356968 3.4355787 0.30674625 0.3234582 0.04243961 0.34425833 0.46493333 0.3291667 -0.13576667 0.13956651 0.00126945 FALSE TRUE
MSTRG.18186.2 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding   9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 0.2391800 0.0000000 0.5594666 0.00000000 0.2076662 5.83153921 0.02265833 0.00000000 0.0536000 0.05360000 0.00126945 0.00126945 FALSE TRUE
MSTRG.18186.6 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding   9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 1.7766208 1.5390063 1.7296869 0.06189139 0.3809854 0.16748467 0.19588750 0.21646667 0.1670333 -0.04943333 0.65200104 0.00126945 FALSE TRUE
MSTRG.18186.8 ENSG00000049323 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP1 protein_coding   9.337705 7.190015 10.41045 0.4260149 0.1836795 0.5333457 1.8635245 1.0845626 2.0569525 0.22851265 0.2275277 0.91715076 0.19992500 0.14833333 0.1984333 0.05010000 0.55500052 0.00126945 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049323 E001 1.5157059 0.0158844326 3.106332e-02 7.403542e-02 2 32946819 32946952 134 + 0.528 0.147 -2.558
ENSG00000049323 E002 10.6928503 0.0374242071 3.205334e-03 1.087193e-02 2 32946953 32947437 485 + 1.190 0.800 -1.447
ENSG00000049323 E003 3.2119451 0.0047741099 1.336862e-03 5.099355e-03 2 32947438 32947489 52 + 0.778 0.256 -2.636
ENSG00000049323 E004 2.8819726 0.0156549267 4.160316e-03 1.359270e-02 2 32947490 32947510 21 + 0.738 0.256 -2.475
ENSG00000049323 E005 3.2182879 0.0047733662 1.336674e-03 5.098840e-03 2 32947511 32947552 42 + 0.778 0.256 -2.636
ENSG00000049323 E006 3.8094740 0.0040747292 2.104941e-04 1.008790e-03 2 32947553 32947577 25 + 0.849 0.256 -2.912
ENSG00000049323 E007 20.3338868 0.0114417193 7.597557e-05 4.089715e-04 2 32947578 32947818 241 + 1.445 1.091 -1.245
ENSG00000049323 E008 22.5901783 0.0018983119 1.272692e-04 6.468519e-04 2 32948875 32948945 71 + 1.469 1.201 -0.934
ENSG00000049323 E009 64.9560610 0.0003662506 1.555234e-08 1.849441e-07 2 33020909 33021206 298 + 1.902 1.675 -0.767
ENSG00000049323 E010 60.6290838 0.0004143235 5.518636e-08 5.891075e-07 2 33110582 33110751 170 + 1.870 1.644 -0.766
ENSG00000049323 E011 0.0000000       2 33134406 33134505 100 +      
ENSG00000049323 E012 0.0000000       2 33134597 33134624 28 +      
ENSG00000049323 E013 0.0000000       2 33134625 33134638 14 +      
ENSG00000049323 E014 0.0000000       2 33134639 33134656 18 +      
ENSG00000049323 E015 0.1817044 0.0394451842 3.488568e-01   2 33134657 33134792 136 + 0.000 0.147 10.384
ENSG00000049323 E016 53.9854573 0.0004163985 1.395369e-08 1.674575e-07 2 33134793 33134960 168 + 1.830 1.575 -0.863
ENSG00000049323 E017 70.3257999 0.0004513431 1.022283e-08 1.257996e-07 2 33186856 33187080 225 + 1.935 1.713 -0.747
ENSG00000049323 E018 88.1649428 0.0003045242 6.948936e-06 4.790070e-05 2 33188577 33188851 275 + 2.003 1.861 -0.479
ENSG00000049323 E019 48.4378871 0.0081561238 2.121883e-01 3.411070e-01 2 33217552 33217654 103 + 1.714 1.663 -0.175
ENSG00000049323 E020 36.4749352 0.0049638475 7.765643e-02 1.556983e-01 2 33222080 33222151 72 + 1.605 1.517 -0.300
ENSG00000049323 E021 43.9104326 0.0004969530 4.388505e-02 9.817314e-02 2 33243662 33243784 123 + 1.680 1.602 -0.264
ENSG00000049323 E022 38.7127042 0.0005602572 1.271341e-03 4.881663e-03 2 33252677 33252726 50 + 1.655 1.499 -0.532
ENSG00000049323 E023 56.0320363 0.0004606760 7.741093e-03 2.312769e-02 2 33252727 33252844 118 + 1.793 1.696 -0.327
ENSG00000049323 E024 26.7840431 0.0007306611 5.391644e-03 1.699185e-02 2 33257284 33257367 84 + 1.502 1.341 -0.558
ENSG00000049323 E025 29.5282139 0.0006691004 3.737986e-03 1.240476e-02 2 33257368 33257442 75 + 1.540 1.379 -0.555
ENSG00000049323 E026 48.9098853 0.0011838027 5.007945e-02 1.093019e-01 2 33257443 33257511 69 + 1.721 1.648 -0.247
ENSG00000049323 E027 34.4047988 0.0013288526 2.531469e-01 3.896262e-01 2 33259588 33259610 23 + 1.557 1.516 -0.138
ENSG00000049323 E028 56.0672842 0.0010599126 2.873583e-01 4.278637e-01 2 33262722 33262821 100 + 1.758 1.737 -0.073
ENSG00000049323 E029 0.4482035 0.0292875142 1.546310e-01 2.679152e-01 2 33262822 33262824 3 + 0.253 0.000 -11.021
ENSG00000049323 E030 57.0544461 0.0051809818 6.229588e-01 7.396584e-01 2 33263294 33263392 99 + 1.758 1.762 0.013
ENSG00000049323 E031 63.9179124 0.0006460858 8.165431e-03 2.420195e-02 2 33273656 33273781 126 + 1.845 1.755 -0.302
ENSG00000049323 E032 65.7732127 0.0004033809 6.317706e-02 1.320000e-01 2 33274965 33275090 126 + 1.842 1.791 -0.172
ENSG00000049323 E033 58.1520216 0.0004280891 9.332453e-02 1.803149e-01 2 33275801 33275908 108 + 1.787 1.740 -0.161
ENSG00000049323 E034 34.1820268 0.0005804443 3.639356e-02 8.433204e-02 2 33275909 33275923 15 + 1.584 1.488 -0.329
ENSG00000049323 E035 49.5073029 0.0032023076 9.313522e-01 9.607559e-01 2 33280039 33280158 120 + 1.689 1.717 0.092
ENSG00000049323 E036 0.0000000       2 33291484 33291787 304 +      
ENSG00000049323 E037 69.1988643 0.0008080313 6.975309e-01 7.976456e-01 2 33293160 33293282 123 + 1.835 1.849 0.047
ENSG00000049323 E038 74.5726965 0.0027466876 8.550678e-01 9.103632e-01 2 33300451 33300573 123 + 1.864 1.887 0.078
ENSG00000049323 E039 36.2974606 0.0081051944 8.468819e-01 9.048504e-01 2 33301522 33301529 8 + 1.563 1.580 0.058
ENSG00000049323 E040 69.0055154 0.0004167558 8.822408e-01 9.286108e-01 2 33301530 33301631 102 + 1.832 1.856 0.082
ENSG00000049323 E041 35.5800867 0.0007758200 2.689864e-01 4.074542e-01 2 33301632 33301644 13 + 1.572 1.537 -0.122
ENSG00000049323 E042 65.7940394 0.0004012219 7.856846e-03 2.342107e-02 2 33309434 33309556 123 + 1.855 1.767 -0.294
ENSG00000049323 E043 67.3841708 0.0004008446 4.110467e-01 5.546417e-01 2 33315144 33315269 126 + 1.833 1.829 -0.016
ENSG00000049323 E044 0.0000000       2 33317698 33317940 243 +      
ENSG00000049323 E045 58.9763650 0.0003891415 3.591652e-01 5.034984e-01 2 33342838 33342963 126 + 1.740 1.813 0.245
ENSG00000049323 E046 83.7969235 0.0003397778 1.220517e-01 2.228679e-01 2 33347367 33347510 144 + 1.882 1.973 0.304
ENSG00000049323 E047 31.8171425 0.0080682161 5.667723e-01 6.936613e-01 2 33360597 33360602 6 + 1.480 1.551 0.244
ENSG00000049323 E048 85.9075117 0.0036813577 2.152645e-01 3.447330e-01 2 33360603 33360779 177 + 1.896 1.985 0.300
ENSG00000049323 E049 66.3407612 0.0003798129 3.580403e-01 5.024420e-01 2 33361429 33361515 87 + 1.793 1.863 0.237
ENSG00000049323 E050 80.4320887 0.0009482634 5.349233e-03 1.688178e-02 2 33363390 33363518 129 + 1.833 1.979 0.489
ENSG00000049323 E051 86.5776749 0.0008928111 3.537218e-03 1.183238e-02 2 33364216 33364356 141 + 1.863 2.009 0.493
ENSG00000049323 E052 92.6848437 0.0007539993 3.330494e-04 1.512458e-03 2 33365333 33365503 171 + 1.883 2.050 0.562
ENSG00000049323 E053 89.4265908 0.0003631025 2.770245e-09 3.785722e-08 2 33389184 33389306 123 + 1.821 2.075 0.852
ENSG00000049323 E054 107.5551820 0.0033314740 4.807794e-06 3.437584e-05 2 33397133 33397282 150 + 1.917 2.145 0.764
ENSG00000049323 E055 324.1456612 0.0069316933 2.680195e-14 8.272318e-13 2 33398364 33399509 1146 + 2.322 2.669 1.156