ENSG00000049246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361923 ENSG00000049246 HEK293_OSMI2_2hA HEK293_TMG_2hB PER3 protein_coding protein_coding 0.5609796 0.4378298 0.7236781 0.04498573 0.0391463 0.7121966 0.10201965 0.22049418 0.05638465 0.004946363 0.05638465 -1.795809 0.20812083 0.51756667 0.07970000 -0.43786667 0.03948057 0.03948057 FALSE TRUE
ENST00000377532 ENSG00000049246 HEK293_OSMI2_2hA HEK293_TMG_2hB PER3 protein_coding protein_coding 0.5609796 0.4378298 0.7236781 0.04498573 0.0391463 0.7121966 0.14288947 0.02753000 0.19790103 0.027530001 0.12099913 2.469781 0.24597500 0.07883333 0.28500000 0.20616667 0.63715963 0.03948057 FALSE TRUE
ENST00000463106 ENSG00000049246 HEK293_OSMI2_2hA HEK293_TMG_2hB PER3 protein_coding retained_intron 0.5609796 0.4378298 0.7236781 0.04498573 0.0391463 0.7121966 0.03404830 0.06194357 0.02584086 0.039848265 0.02584086 -1.005261 0.05959583 0.13030000 0.03236667 -0.09793333 0.48464325 0.03948057   FALSE
ENST00000613533 ENSG00000049246 HEK293_OSMI2_2hA HEK293_TMG_2hB PER3 protein_coding protein_coding 0.5609796 0.4378298 0.7236781 0.04498573 0.0391463 0.7121966 0.11875909 0.08070570 0.18173536 0.040354499 0.18173536 1.079851 0.19566250 0.16750000 0.22770000 0.06020000 0.74893565 0.03948057 FALSE TRUE
ENST00000614998 ENSG00000049246 HEK293_OSMI2_2hA HEK293_TMG_2hB PER3 protein_coding protein_coding 0.5609796 0.4378298 0.7236781 0.04498573 0.0391463 0.7121966 0.08642577 0.00000000 0.20960693 0.000000000 0.13199434 4.456852 0.16955417 0.00000000 0.30033333 0.30033333 0.36970164 0.03948057 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049246 E001 0.2944980 0.397677073 5.790772e-01   1 7784291 7784319 29 + 0.158 0.000 -10.290
ENSG00000049246 E002 0.4396707 0.026311332 2.560435e-01 0.3929989280 1 7784320 7784376 57 + 0.220 0.000 -13.408
ENSG00000049246 E003 0.0000000       1 7784429 7784468 40 +      
ENSG00000049246 E004 0.6192988 0.020364943 7.278604e-01 0.8204426559 1 7784654 7784702 49 + 0.220 0.171 -0.457
ENSG00000049246 E005 3.8645508 0.004478819 9.958038e-01 1.0000000000 1 7784703 7785005 303 + 0.655 0.686 0.128
ENSG00000049246 E006 4.0128440 0.004557949 7.758574e-01 0.8556367957 1 7785441 7785522 82 + 0.655 0.727 0.298
ENSG00000049246 E007 4.0859088 0.004881415 5.845553e-01 0.7084402619 1 7785523 7785586 64 + 0.655 0.764 0.449
ENSG00000049246 E008 4.1792495 0.026178846 7.114616e-01 0.8084129842 1 7786721 7786836 116 + 0.715 0.684 -0.126
ENSG00000049246 E009 0.7406253 0.015572514 8.940922e-02 0.1742283764 1 7787198 7787246 49 + 0.322 0.000 -13.947
ENSG00000049246 E010 0.1451727 0.043067014 1.000000e+00   1 7787322 7788044 723 + 0.086 0.000 -12.110
ENSG00000049246 E011 4.8666562 0.012381961 1.683646e-01 0.2860602915 1 7788045 7788246 202 + 0.813 0.639 -0.714
ENSG00000049246 E012 1.1080718 0.411911789 3.444015e-01 0.4884949126 1 7788247 7788338 92 + 0.220 0.458 1.505
ENSG00000049246 E013 1.2563650 0.497240406 2.915284e-01 0.4324002308 1 7788339 7788570 232 + 0.220 0.519 1.804
ENSG00000049246 E014 0.4439371 0.021720478 2.556499e-01 0.3925595041 1 7793957 7793959 3 + 0.220 0.000 -13.412
ENSG00000049246 E015 1.1823843 0.012448675 6.107738e-01 0.7300591238 1 7793960 7794008 49 + 0.366 0.292 -0.460
ENSG00000049246 E016 3.2399560 0.004970752 3.429441e-01 0.4869746782 1 7798525 7798673 149 + 0.655 0.532 -0.551
ENSG00000049246 E017 3.2452546 0.004955423 1.470123e-01 0.2576175692 1 7801113 7801191 79 + 0.676 0.466 -0.960
ENSG00000049246 E018 1.5166363 0.008990193 3.537846e-01 0.4980487929 1 7803047 7803050 4 + 0.441 0.293 -0.873
ENSG00000049246 E019 3.1429458 0.005065085 1.050354e-02 0.0299872505 1 7803051 7803153 103 + 0.715 0.293 -2.121
ENSG00000049246 E020 5.4522653 0.003411868 8.040668e-02 0.1601969222 1 7803692 7803848 157 + 0.855 0.640 -0.872
ENSG00000049246 E021 0.0000000       1 7803849 7803958 110 +      
ENSG00000049246 E022 5.0449460 0.032213921 6.704212e-01 0.7768674247 1 7808893 7808998 106 + 0.767 0.730 -0.147
ENSG00000049246 E023 5.4113866 0.003427330 2.727926e-01 0.4117481006 1 7809893 7810021 129 + 0.715 0.889 0.688
ENSG00000049246 E024 0.6632174 0.018948397 9.169587e-02 0.1777827515 1 7810022 7810347 326 + 0.086 0.388 2.711
ENSG00000049246 E025 4.6629260 0.004559554 8.001678e-01 0.8726176650 1 7810438 7810567 130 + 0.733 0.727 -0.024
ENSG00000049246 E026 0.7427016 0.015611596 8.937391e-02 0.1741732530 1 7810568 7810588 21 + 0.322 0.000 -13.947
ENSG00000049246 E027 3.2536987 0.005657588 6.426491e-01 0.7553960718 1 7819285 7819420 136 + 0.634 0.589 -0.195
ENSG00000049246 E028 3.0364923 0.005343415 8.756595e-01 0.9241479531 1 7820115 7820239 125 + 0.587 0.590 0.012
ENSG00000049246 E029 4.8507351 0.050077906 2.850908e-01 0.4253987949 1 7820467 7820640 174 + 0.799 0.641 -0.648
ENSG00000049246 E030 4.1541196 0.101453373 1.067056e-01 0.2006826531 1 7826480 7826710 231 + 0.784 0.467 -1.395
ENSG00000049246 E031 10.7801296 0.003016006 6.674030e-01 0.7746482504 1 7827118 7827815 698 + 1.055 1.045 -0.035
ENSG00000049246 E032 1.6002957 0.010602124 6.592819e-01 0.7681269922 1 7829834 7829836 3 + 0.366 0.466 0.541
ENSG00000049246 E033 5.0368065 0.003440806 3.074748e-01 0.4497076610 1 7829837 7829951 115 + 0.798 0.686 -0.458
ENSG00000049246 E034 2.4807831 0.006229046 1.969951e-01 0.3224619699 1 7829952 7830005 54 + 0.587 0.388 -0.988
ENSG00000049246 E035 3.3824887 0.006894723 7.919965e-03 0.0235769527 1 7830006 7830161 156 + 0.733 0.293 -2.194
ENSG00000049246 E036 4.1909925 0.045538602 1.439043e-01 0.2533265094 1 7835762 7835945 184 + 0.767 0.533 -1.009
ENSG00000049246 E037 0.0000000       1 7836808 7836998 191 +      
ENSG00000049246 E038 3.2988373 0.067452719 8.367896e-01 0.8979332116 1 7836999 7837149 151 + 0.612 0.594 -0.076
ENSG00000049246 E039 5.8198613 0.010690800 1.788091e-01 0.2996527677 1 7842672 7842884 213 + 0.733 0.939 0.806
ENSG00000049246 E040 30.6422661 0.033672778 3.965676e-05 0.0002287645 1 7842885 7845176 2292 + 1.299 1.697 1.366
ENSG00000049246 E041 0.2214452 0.039282382 2.429629e-01   1 7845177 7845177 1 + 0.000 0.171 12.634