ENSG00000049130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347404 ENSG00000049130 HEK293_OSMI2_2hA HEK293_TMG_2hB KITLG protein_coding protein_coding 2.061191 0.4085907 3.310292 0.04800179 0.1442815 2.987698 0.47200132 0.1828653 0.8602724 0.07249229 0.2375997 2.173873 0.18860000 0.4969667 0.2574000 -0.2395667 0.7350477654 0.0001091931 FALSE TRUE
ENST00000378535 ENSG00000049130 HEK293_OSMI2_2hA HEK293_TMG_2hB KITLG protein_coding processed_transcript 2.061191 0.4085907 3.310292 0.04800179 0.1442815 2.987698 0.61134752 0.2257254 0.6033735 0.11296353 0.3542182 1.379658 0.37201667 0.5030333 0.1900333 -0.3130000 0.6477885069 0.0001091931 FALSE TRUE
ENST00000644744 ENSG00000049130 HEK293_OSMI2_2hA HEK293_TMG_2hB KITLG protein_coding protein_coding 2.061191 0.4085907 3.310292 0.04800179 0.1442815 2.987698 0.86777794 0.0000000 1.5381318 0.00000000 0.3367270 7.274384 0.40520000 0.0000000 0.4583667 0.4583667 0.0001091931 0.0001091931 FALSE TRUE
ENST00000646633 ENSG00000049130 HEK293_OSMI2_2hA HEK293_TMG_2hB KITLG protein_coding nonsense_mediated_decay 2.061191 0.4085907 3.310292 0.04800179 0.1442815 2.987698 0.09679757 0.0000000 0.2586034 0.00000000 0.1732031 4.747406 0.02765417 0.0000000 0.0787000 0.0787000 0.7106419804 0.0001091931 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000049130 E001 57.109926 0.0005466692 1.023446e-09 1.515348e-08 12 88492793 88494470 1678 - 1.543 1.862 1.082
ENSG00000049130 E002 135.785298 0.0003562229 5.158874e-02 1.119800e-01 12 88494471 88497079 2609 - 1.984 1.912 -0.239
ENSG00000049130 E003 9.349758 0.0018628365 3.534500e-01 4.976888e-01 12 88497080 88497181 102 - 0.888 0.739 -0.586
ENSG00000049130 E004 12.537743 0.0013783957 1.770168e-01 2.973671e-01 12 88505159 88505235 77 - 1.004 0.805 -0.756
ENSG00000049130 E005 12.043456 0.0015189153 2.161660e-01 3.457908e-01 12 88506311 88506378 68 - 0.988 0.805 -0.699
ENSG00000049130 E006 14.920820 0.0075169951 6.268759e-01 7.427582e-01 12 88507028 88507137 110 - 1.061 0.998 -0.229
ENSG00000049130 E007 8.273507 0.0094764425 8.561665e-01 9.110671e-01 12 88515534 88515617 84 - 0.832 0.805 -0.105
ENSG00000049130 E008 13.290347 0.0077148518 2.444418e-01 3.793953e-01 12 88516334 88516490 157 - 1.029 0.862 -0.626
ENSG00000049130 E009 14.247852 0.0013473643 4.923012e-01 6.294870e-01 12 88518697 88518832 136 - 1.047 0.958 -0.332
ENSG00000049130 E010 10.339389 0.0019105914 4.502490e-01 5.913803e-01 12 88518833 88518867 35 - 0.920 0.805 -0.444
ENSG00000049130 E011 11.105846 0.0016494858 2.018290e-01 3.284702e-01 12 88532441 88532503 63 - 0.908 1.071 0.603
ENSG00000049130 E012 0.000000       12 88534691 88534762 72 -      
ENSG00000049130 E013 14.474243 0.0071275235 4.986470e-01 6.351083e-01 12 88545752 88545865 114 - 1.052 0.958 -0.347
ENSG00000049130 E014 0.147249 0.0438969151 7.275060e-01   12 88564208 88564344 137 - 0.048 0.001 -5.856
ENSG00000049130 E015 0.000000       12 88580089 88580263 175 -      
ENSG00000049130 E016 14.001352 0.0120420314 4.914996e-02 1.076403e-01 12 88580264 88580851 588 - 1.057 0.740 -1.209