ENSG00000048828

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000652239 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding protein_coding 50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 2.255036 4.113245 0.0000000 2.4557546 0.0000000 -8.6876363 0.04320833 0.07043333 0.00000000 -0.07043333 1.705526e-01 1.667614e-35 FALSE TRUE
MSTRG.33016.10 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding   50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 15.961659 13.026594 19.8149477 1.9936541 0.2355849 0.6047501 0.32015833 0.21986667 0.38926667 0.16940000 4.923845e-05 1.667614e-35 FALSE TRUE
MSTRG.33016.14 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding   50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 7.615460 24.000861 0.1282614 0.6812468 0.1282614 -7.4401448 0.15316250 0.40933333 0.00250000 -0.40683333 7.339062e-06 1.667614e-35   FALSE
MSTRG.33016.2 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding   50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 9.337433 6.054908 14.7888168 1.9680425 0.5481531 1.2869243 0.18421667 0.10323333 0.29066667 0.18743333 2.194497e-02 1.667614e-35 FALSE TRUE
MSTRG.33016.4 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding   50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 9.269092 6.634351 8.1810216 0.2112845 1.0944805 0.3019150 0.18342500 0.11320000 0.16053333 0.04733333 2.059398e-01 1.667614e-35 FALSE TRUE
MSTRG.33016.5 ENSG00000048828 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM120A protein_coding   50.1969 58.70604 50.90469 2.569025 0.3860112 -0.2056727 1.768833 0.000000 4.7282607 0.0000000 0.5363712 8.8882138 0.03613333 0.00000000 0.09283333 0.09283333 1.667614e-35 1.667614e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000048828 E001 3.1848872 0.0052006331 7.974014e-02 1.591516e-01 9 93451685 93451890 206 + 0.691 0.482 -0.941
ENSG00000048828 E002 21.2793738 0.0152358307 1.967299e-04 9.498660e-04 9 93451891 93451944 54 + 1.441 1.161 -0.979
ENSG00000048828 E003 24.5017205 0.0226698574 4.500156e-03 1.454302e-02 9 93451945 93451951 7 + 1.477 1.271 -0.714
ENSG00000048828 E004 29.4766255 0.0183824291 3.051043e-04 1.400220e-03 9 93451952 93451961 10 + 1.568 1.317 -0.867
ENSG00000048828 E005 281.9342922 0.0111204934 8.117938e-05 4.335830e-04 9 93451962 93452383 422 + 2.494 2.377 -0.392
ENSG00000048828 E006 104.0844374 0.0138973689 1.898814e-02 4.930860e-02 9 93452384 93452389 6 + 2.042 1.981 -0.204
ENSG00000048828 E007 0.1482932 0.0418623566 3.928989e-01   9 93459787 93459875 89 + 0.000 0.148 11.022
ENSG00000048828 E008 0.9911135 0.0122600137 7.769926e-01 8.564300e-01 9 93470375 93470405 31 + 0.251 0.346 0.644
ENSG00000048828 E009 1.9854467 0.0084561537 5.864004e-02 1.242985e-01 9 93470406 93470430 25 + 0.251 0.629 2.060
ENSG00000048828 E010 380.9608871 0.0056659735 7.329868e-06 5.022321e-05 9 93471141 93471387 247 + 2.611 2.528 -0.278
ENSG00000048828 E011 268.4941975 0.0010104318 3.003076e-11 5.784686e-10 9 93476256 93476338 83 + 2.458 2.374 -0.280
ENSG00000048828 E012 340.2290919 0.0019871774 2.627690e-11 5.110440e-10 9 93497471 93497599 129 + 2.567 2.469 -0.327
ENSG00000048828 E013 263.0279351 0.0002437465 2.244845e-12 5.202827e-11 9 93498790 93498886 97 + 2.444 2.375 -0.231
ENSG00000048828 E014 96.4908273 0.0003039360 3.898206e-06 2.842038e-05 9 93515667 93515669 3 + 2.014 1.935 -0.267
ENSG00000048828 E015 152.7744463 0.0005930912 4.851793e-06 3.465643e-05 9 93515670 93515767 98 + 2.202 2.152 -0.166
ENSG00000048828 E016 382.9979971 0.0010745479 1.692484e-10 2.873083e-09 9 93515983 93516269 287 + 2.602 2.543 -0.196
ENSG00000048828 E017 335.1069706 0.0001632724 2.788690e-17 1.284798e-15 9 93527155 93527242 88 + 2.553 2.474 -0.261
ENSG00000048828 E018 363.7493504 0.0004862504 2.316704e-10 3.835469e-09 9 93529353 93529469 117 + 2.573 2.531 -0.139
ENSG00000048828 E019 318.2909786 0.0027125666 1.412476e-04 7.089775e-04 9 93529470 93529580 111 + 2.512 2.483 -0.095
ENSG00000048828 E020 4.7724723 0.0035167122 1.914951e-02 4.966179e-02 9 93529581 93530710 1130 + 0.844 0.585 -1.072
ENSG00000048828 E021 2.2551707 0.0063806871 7.854465e-02 1.571557e-01 9 93530711 93530731 21 + 0.587 0.347 -1.230
ENSG00000048828 E022 2.1066765 0.0165824777 8.440284e-02 1.664519e-01 9 93530732 93531406 675 + 0.587 0.346 -1.234
ENSG00000048828 E023 384.2660274 0.0009080915 1.054320e-04 5.470621e-04 9 93532155 93532329 175 + 2.577 2.581 0.014
ENSG00000048828 E024 13.6011090 0.0429914362 2.692572e-04 1.254549e-03 9 93532330 93532589 260 + 0.811 1.401 2.144
ENSG00000048828 E025 424.0079133 0.0006206808 7.118027e-06 4.892921e-05 9 93543222 93543471 250 + 2.621 2.621 0.001
ENSG00000048828 E026 275.5660709 0.0001780842 2.809403e-06 2.116739e-05 9 93550577 93550691 115 + 2.439 2.428 -0.037
ENSG00000048828 E027 256.1301223 0.0003417834 1.446698e-03 5.462226e-03 9 93556382 93556451 70 + 2.395 2.412 0.057
ENSG00000048828 E028 346.5461523 0.0005320887 1.478511e-01 2.587620e-01 9 93556452 93556591 140 + 2.507 2.568 0.204
ENSG00000048828 E029 419.1331133 0.0011374286 9.031821e-01 9.424009e-01 9 93557827 93558010 184 + 2.573 2.670 0.323
ENSG00000048828 E030 323.2219045 0.0006766514 2.079966e-01 3.360840e-01 9 93558581 93558718 138 + 2.476 2.540 0.214
ENSG00000048828 E031 25.4175646 0.0087670500 2.327710e-08 2.679086e-07 9 93559002 93559061 60 + 1.549 1.147 -1.400
ENSG00000048828 E032 124.3424174 0.0023239948 3.498683e-01 4.940592e-01 9 93561109 93561111 3 + 2.065 2.122 0.191
ENSG00000048828 E033 326.0486873 0.0001508521 1.508514e-01 2.628360e-01 9 93561112 93561250 139 + 2.479 2.542 0.211
ENSG00000048828 E034 297.7755658 0.0001395799 1.995368e-02 5.138906e-02 9 93562208 93562304 97 + 2.449 2.493 0.145
ENSG00000048828 E035 2744.1387381 0.0056949955 5.516197e-23 4.887872e-21 9 93564229 93566112 1884 + 3.234 3.604 1.230