ENSG00000048707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000011700 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding protein_coding 5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 0.8538901 0.7086749 0.7188331 0.17449465 0.06820389 0.02024905 0.16058333 0.14333333 0.15496667 0.01163333 8.888868e-01 1.285022e-19 FALSE TRUE
ENST00000613099 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding protein_coding 5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 0.6414770 0.4355137 0.7219097 0.07075624 0.30848437 0.71619566 0.12286667 0.08840000 0.15486667 0.06646667 8.053714e-01 1.285022e-19 FALSE TRUE
ENST00000646411 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding retained_intron 5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 1.1045719 2.2488351 0.0000000 0.14858870 0.00000000 -7.81943516 0.20169583 0.46770000 0.00000000 -0.46770000 1.285022e-19 1.285022e-19 FALSE TRUE
ENST00000647414 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding retained_intron 5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 0.3494991 0.1607636 0.2492707 0.08474654 0.18489670 0.60245856 0.06144583 0.03476667 0.05046667 0.01570000 1.000000e+00 1.285022e-19 FALSE FALSE
MSTRG.334.1 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding   5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 1.0991299 0.1408897 1.8966851 0.14088972 0.17180382 3.65950017 0.22932917 0.02726667 0.41406667 0.38680000 7.575176e-03 1.285022e-19 FALSE TRUE
MSTRG.334.11 ENSG00000048707 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13D protein_coding   5.223775 4.865747 4.625114 0.2498918 0.2331844 -0.07301844 0.6240787 0.9263792 0.5932422 0.09959681 0.11556010 -0.63435547 0.11435417 0.18923333 0.12650000 -0.06273333 2.973708e-01 1.285022e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000048707 E001 0.1472490 0.0428431857 6.461754e-01   1 12230024 12230029 6 + 0.104 0.000 -11.525
ENSG00000048707 E002 0.2944980 0.3301230139 3.907552e-01   1 12230030 12230036 7 + 0.187 0.000 -14.766
ENSG00000048707 E003 1.0759214 0.0115635710 1.114155e-01 2.076267e-01 1 12230037 12230050 14 + 0.418 0.144 -2.043
ENSG00000048707 E004 1.6713740 0.0088719007 1.517992e-02 4.089576e-02 1 12230051 12230066 16 + 0.568 0.144 -2.780
ENSG00000048707 E005 4.6168199 0.0035049413 6.319632e-04 2.650686e-03 1 12230067 12230120 54 + 0.904 0.410 -2.158
ENSG00000048707 E006 10.4408920 0.0015860278 4.809019e-09 6.296595e-08 1 12234191 12234363 173 + 1.248 0.574 -2.605
ENSG00000048707 E007 11.7956312 0.0050667120 1.153519e-08 1.406518e-07 1 12242513 12242590 78 + 1.292 0.657 -2.396
ENSG00000048707 E008 16.0988712 0.0014381456 5.343878e-08 5.724522e-07 1 12244246 12244423 178 + 1.389 0.907 -1.731
ENSG00000048707 E009 8.3819695 0.0065049397 2.642834e-04 1.234106e-03 1 12244424 12244436 13 + 1.118 0.692 -1.629
ENSG00000048707 E010 10.5316196 0.0127345421 1.708062e-03 6.307005e-03 1 12244537 12244617 81 + 1.185 0.838 -1.279
ENSG00000048707 E011 8.8961867 0.0029350211 1.742880e-02 4.588813e-02 1 12249223 12249339 117 + 1.081 0.839 -0.907
ENSG00000048707 E012 0.4772466 0.0204769266 4.046390e-01 5.483379e-01 1 12249340 12249603 264 + 0.104 0.252 1.541
ENSG00000048707 E013 7.2989123 0.0029863970 7.257934e-03 2.189571e-02 1 12253722 12253733 12 + 1.030 0.726 -1.168
ENSG00000048707 E014 11.2837454 0.0015473131 9.812658e-04 3.895760e-03 1 12253734 12253826 93 + 1.200 0.885 -1.151
ENSG00000048707 E015 0.4482035 0.0305215978 1.442266e-01 2.537548e-01 1 12256276 12256332 57 + 0.258 0.000 -16.152
ENSG00000048707 E016 13.6919811 0.0163884505 5.365146e-06 3.791587e-05 1 12256333 12256503 171 + 1.326 0.814 -1.872
ENSG00000048707 E017 14.4252577 0.0266230301 1.768339e-05 1.110065e-04 1 12256987 12257087 101 + 1.348 0.840 -1.845
ENSG00000048707 E018 14.5405195 0.0027522111 1.655392e-08 1.959811e-07 1 12257935 12258103 169 + 1.359 0.813 -1.990
ENSG00000048707 E019 11.4846619 0.0015515709 2.107828e-10 3.517014e-09 1 12260693 12260794 102 + 1.292 0.574 -2.759
ENSG00000048707 E020 13.5998672 0.0012826361 1.328064e-07 1.317749e-06 1 12260948 12261149 202 + 1.321 0.813 -1.860
ENSG00000048707 E021 12.9270213 0.0015168780 7.388835e-06 5.057968e-05 1 12261901 12262080 180 + 1.286 0.862 -1.545
ENSG00000048707 E022 9.9508938 0.0021479802 5.287425e-05 2.961555e-04 1 12266881 12267011 131 + 1.184 0.757 -1.601
ENSG00000048707 E023 8.6264573 0.0021936475 3.719527e-04 1.665847e-03 1 12267845 12267920 76 + 1.118 0.726 -1.490
ENSG00000048707 E024 10.0710744 0.0016273344 3.444948e-05 2.017856e-04 1 12268706 12268876 171 + 1.192 0.757 -1.628
ENSG00000048707 E025 9.0120667 0.0018608967 9.271018e-06 6.209792e-05 1 12270994 12271124 131 + 1.161 0.656 -1.932
ENSG00000048707 E026 12.7691475 0.0014024565 3.166421e-04 1.447246e-03 1 12273003 12273135 133 + 1.255 0.927 -1.187
ENSG00000048707 E027 63.1823874 0.0072043272 3.168293e-14 9.685713e-13 1 12275825 12277120 1296 + 1.954 1.498 -1.548
ENSG00000048707 E028 32.6709906 0.0044438852 8.175506e-08 8.445986e-07 1 12277121 12277534 414 + 1.648 1.291 -1.228
ENSG00000048707 E029 33.9144812 0.0006652238 2.414951e-07 2.278526e-06 1 12277535 12277902 368 + 1.650 1.354 -1.016
ENSG00000048707 E030 15.4940008 0.0020802447 3.663409e-03 1.219208e-02 1 12277903 12278038 136 + 1.310 1.079 -0.821
ENSG00000048707 E031 16.0348592 0.0011633923 2.357437e-02 5.893578e-02 1 12279499 12279650 152 + 1.298 1.132 -0.587
ENSG00000048707 E032 59.1836352 0.0094317626 2.301458e-04 1.092332e-03 1 12282705 12283434 730 + 1.857 1.652 -0.693
ENSG00000048707 E033 31.1939898 0.0120286378 6.736550e-05 3.674053e-04 1 12283435 12283736 302 + 1.617 1.309 -1.062
ENSG00000048707 E034 16.8954855 0.0012314369 4.802718e-03 1.538096e-02 1 12288223 12288313 91 + 1.332 1.120 -0.751
ENSG00000048707 E035 17.0843233 0.0013404742 2.650087e-02 6.495176e-02 1 12290998 12291124 127 + 1.316 1.157 -0.559
ENSG00000048707 E036 18.4478550 0.0009968446 8.296409e-06 5.615728e-05 1 12293524 12293704 181 + 1.412 1.065 -1.226
ENSG00000048707 E037 11.7725105 0.0014671753 7.847063e-06 5.340384e-05 1 12299202 12299280 79 + 1.255 0.813 -1.628
ENSG00000048707 E038 17.1132141 0.0011217762 9.336701e-07 7.797267e-06 1 12299281 12299384 104 + 1.393 0.984 -1.457
ENSG00000048707 E039 28.7119002 0.0029127002 4.825103e-05 2.729312e-04 1 12304506 12304728 223 + 1.567 1.307 -0.896
ENSG00000048707 E040 26.7905169 0.0147775485 1.909908e-01 3.149987e-01 1 12308431 12308641 211 + 1.471 1.394 -0.264
ENSG00000048707 E041 8.5147001 0.0021868691 9.878562e-01 9.964560e-01 1 12311454 12311467 14 + 0.959 0.984 0.095
ENSG00000048707 E042 14.0949188 0.0077405046 8.284603e-01 8.922100e-01 1 12311468 12311525 58 + 1.169 1.181 0.043
ENSG00000048707 E043 18.7072834 0.0050782642 2.099173e-01 3.384412e-01 1 12311526 12311625 100 + 1.327 1.252 -0.261
ENSG00000048707 E044 17.4622242 0.0010886613 8.214546e-01 8.874233e-01 1 12311813 12311925 113 + 1.242 1.289 0.166
ENSG00000048707 E045 27.7077298 0.0008319945 2.014674e-02 5.179244e-02 1 12314115 12314327 213 + 1.509 1.383 -0.433
ENSG00000048707 E046 36.4537770 0.0175086039 7.038227e-03 2.132404e-02 1 12318072 12318337 266 + 1.648 1.456 -0.653
ENSG00000048707 E047 26.9795269 0.0008000003 2.272888e-02 5.719110e-02 1 12319497 12319630 134 + 1.494 1.369 -0.432
ENSG00000048707 E048 26.7331451 0.0044507696 1.743273e-01 2.938080e-01 1 12321809 12321964 156 + 1.463 1.392 -0.246
ENSG00000048707 E049 28.5316000 0.0024487754 5.389380e-01 6.702685e-01 1 12322536 12322746 211 + 1.467 1.456 -0.039
ENSG00000048707 E050 15.1642562 0.0043498758 9.536503e-01 9.749752e-01 1 12323706 12323780 75 + 1.199 1.223 0.082
ENSG00000048707 E051 30.8856668 0.0011579547 9.799185e-01 9.914746e-01 1 12327648 12327854 207 + 1.483 1.511 0.097
ENSG00000048707 E052 24.2404547 0.0011730577 8.424698e-01 9.018516e-01 1 12329829 12329918 90 + 1.374 1.417 0.151
ENSG00000048707 E053 28.4273109 0.0006885411 4.324536e-01 5.749004e-01 1 12333226 12333366 141 + 1.425 1.506 0.276
ENSG00000048707 E054 27.3482417 0.0007284439 2.075400e-01 3.355336e-01 1 12335705 12335827 123 + 1.393 1.506 0.387
ENSG00000048707 E055 0.1817044 0.0384613198 3.651524e-01   1 12335828 12337988 2161 + 0.000 0.144 14.456
ENSG00000048707 E056 4.3168278 0.0037195367 1.232678e-01 2.246359e-01 1 12338231 12338305 75 + 0.598 0.838 0.989
ENSG00000048707 E057 3.9565275 0.0042959955 4.594209e-01 5.995819e-01 1 12341780 12341782 3 + 0.627 0.757 0.542
ENSG00000048707 E058 27.6249815 0.0007890722 2.612338e-01 3.988777e-01 1 12341783 12341885 103 + 1.475 1.430 -0.155
ENSG00000048707 E059 0.0000000       1 12342805 12342898 94 +      
ENSG00000048707 E060 34.5514587 0.0006078258 2.619647e-02 6.434803e-02 1 12342899 12343051 153 + 1.588 1.484 -0.358
ENSG00000048707 E061 0.1451727 0.0438226367 6.456018e-01   1 12344865 12345010 146 + 0.104 0.000 -14.574
ENSG00000048707 E062 28.3259914 0.0172824610 3.310710e-01 4.746701e-01 1 12345374 12345509 136 + 1.483 1.429 -0.187
ENSG00000048707 E063 17.3013372 0.0171275283 4.667404e-01 6.062943e-01 1 12346605 12346652 48 + 1.275 1.227 -0.169
ENSG00000048707 E064 24.3548071 0.0019249024 7.297302e-01 8.218607e-01 1 12348823 12348973 151 + 1.393 1.398 0.016
ENSG00000048707 E065 3.3893050 0.0134985573 6.893169e-01 7.912184e-01 1 12348974 12349163 190 + 0.654 0.618 -0.157
ENSG00000048707 E066 35.7370117 0.0022549392 4.878808e-01 6.255164e-01 1 12349164 12349374 211 + 1.523 1.597 0.253
ENSG00000048707 E067 40.2171747 0.0005511208 8.699026e-01 9.203130e-01 1 12353974 12354221 248 + 1.591 1.630 0.131
ENSG00000048707 E068 31.5060532 0.0006727950 4.292520e-01 5.719927e-01 1 12355899 12356090 192 + 1.520 1.500 -0.067
ENSG00000048707 E069 0.0000000       1 12356351 12356397 47 +      
ENSG00000048707 E070 25.8150110 0.0009113705 6.321367e-01 7.470395e-01 1 12356398 12356524 127 + 1.393 1.455 0.213
ENSG00000048707 E071 25.6145055 0.0007841871 7.666657e-01 8.490934e-01 1 12358459 12358601 143 + 1.393 1.443 0.171
ENSG00000048707 E072 26.9831561 0.0186460915 6.937594e-01 7.947479e-01 1 12362720 12362850 131 + 1.439 1.446 0.026
ENSG00000048707 E073 37.7722676 0.0005720453 1.188633e-01 2.183169e-01 1 12363072 12363247 176 + 1.523 1.642 0.404
ENSG00000048707 E074 0.0000000       1 12367670 12367701 32 +      
ENSG00000048707 E075 34.3053657 0.0012408510 1.626247e-01 2.785778e-01 1 12368468 12368591 124 + 1.483 1.597 0.391
ENSG00000048707 E076 46.7612315 0.0046209583 4.628620e-01 6.027193e-01 1 12369467 12369702 236 + 1.634 1.709 0.256
ENSG00000048707 E077 32.1907772 0.0007010114 9.403711e-02 1.814382e-01 1 12373750 12373858 109 + 1.447 1.579 0.454
ENSG00000048707 E078 40.4488351 0.0006187809 2.138137e-01 3.430265e-01 1 12378428 12378591 164 + 1.567 1.664 0.333
ENSG00000048707 E079 33.4578478 0.0007063152 4.281078e-01 5.709239e-01 1 12379488 12379596 109 + 1.502 1.579 0.263
ENSG00000048707 E080 18.0366378 0.0100133837 8.093253e-01 8.789160e-01 1 12382976 12382995 20 + 1.280 1.287 0.024
ENSG00000048707 E081 39.5242856 0.0010016496 2.636546e-01 4.015674e-01 1 12382996 12383155 160 + 1.560 1.653 0.316
ENSG00000048707 E082 35.4406199 0.0130350606 4.685245e-02 1.035688e-01 1 12385260 12385373 114 + 1.460 1.646 0.637
ENSG00000048707 E083 43.3268727 0.0198562342 1.563406e-01 2.702544e-01 1 12386185 12386334 150 + 1.567 1.715 0.503
ENSG00000048707 E084 43.4308121 0.0084335183 1.178619e-01 2.168667e-01 1 12400181 12400309 129 + 1.580 1.713 0.454
ENSG00000048707 E085 26.7614770 0.0085164229 9.577780e-02 1.840581e-01 1 12400310 12400330 21 + 1.364 1.525 0.554
ENSG00000048707 E086 36.6221698 0.0011517461 1.179694e-03 4.572396e-03 1 12401608 12401704 97 + 1.463 1.682 0.748
ENSG00000048707 E087 0.2214452 0.0408496620 3.630823e-01   1 12402568 12402702 135 + 0.000 0.144 14.444
ENSG00000048707 E088 56.1767400 0.0004171792 9.177448e-05 4.833046e-04 1 12403825 12403973 149 + 1.645 1.858 0.720
ENSG00000048707 E089 0.0000000       1 12407254 12407330 77 +      
ENSG00000048707 E090 0.0000000       1 12409838 12409894 57 +      
ENSG00000048707 E091 50.7353125 0.0013109093 5.795878e-03 1.807657e-02 1 12415087 12415221 135 + 1.629 1.799 0.578
ENSG00000048707 E092 60.6951425 0.0065732875 3.262547e-02 7.704808e-02 1 12416660 12416827 168 + 1.713 1.870 0.528
ENSG00000048707 E093 0.0000000       1 12453839 12453899 61 +      
ENSG00000048707 E094 50.4930227 0.0008318231 4.036728e-04 1.788712e-03 1 12455998 12456071 74 + 1.606 1.813 0.700
ENSG00000048707 E095 41.0252634 0.0005695124 3.685404e-04 1.652518e-03 1 12456072 12456130 59 + 1.505 1.729 0.763
ENSG00000048707 E096 33.4571300 0.0034979942 1.367353e-04 6.890487e-04 1 12460201 12460239 39 + 1.389 1.667 0.955
ENSG00000048707 E097 55.8868545 0.0006417022 8.943931e-08 9.160409e-07 1 12460240 12460396 157 + 1.603 1.887 0.962
ENSG00000048707 E098 0.2214452 0.0408496620 3.630823e-01   1 12464940 12465249 310 + 0.000 0.144 14.444
ENSG00000048707 E099 0.0000000       1 12478549 12478873 325 +      
ENSG00000048707 E100 0.0000000       1 12497098 12497208 111 +      
ENSG00000048707 E101 0.1451727 0.0438226367 6.456018e-01   1 12497226 12497499 274 + 0.104 0.000 -14.574
ENSG00000048707 E102 49.1413098 0.0008817079 1.192449e-06 9.741946e-06 1 12497500 12497631 132 + 1.551 1.828 0.943
ENSG00000048707 E103 72.4901936 0.0050699163 5.206640e-06 3.690169e-05 1 12506853 12507093 241 + 1.718 1.989 0.912
ENSG00000048707 E104 3.1824910 0.0615281939 1.144717e-01 2.120746e-01 1 12507094 12507163 70 + 0.461 0.756 1.316
ENSG00000048707 E105 343.7804798 0.0087682059 1.434670e-13 3.987586e-12 1 12508893 12512047 3155 + 2.336 2.695 1.197