ENSG00000048405

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265827 ENSG00000048405 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF800 protein_coding protein_coding 6.109639 3.028233 9.685072 0.3695379 0.1287906 1.674019 1.8578973 0.8513346 3.163130 0.07456524 0.07658146 1.881261 0.2747625 0.2842000 0.3268667 0.04266667 6.289112e-01 7.140791e-26 FALSE TRUE
ENST00000393312 ENSG00000048405 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF800 protein_coding protein_coding 6.109639 3.028233 9.685072 0.3695379 0.1287906 1.674019 1.2685126 0.0000000 2.628934 0.00000000 0.19135082 8.043811 0.1382542 0.0000000 0.2710000 0.27100000 1.666783e-17 7.140791e-26 FALSE TRUE
ENST00000485577 ENSG00000048405 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF800 protein_coding processed_transcript 6.109639 3.028233 9.685072 0.3695379 0.1287906 1.674019 0.5434185 1.4995457 0.000000 0.26241689 0.00000000 -7.237971 0.1901667 0.4941667 0.0000000 -0.49416667 7.140791e-26 7.140791e-26 FALSE TRUE
MSTRG.30605.1 ENSG00000048405 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF800 protein_coding   6.109639 3.028233 9.685072 0.3695379 0.1287906 1.674019 1.6855507 0.3465850 2.683678 0.19116717 0.10079226 2.917259 0.2847458 0.1198667 0.2770667 0.15720000 4.188409e-01 7.140791e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000048405 E001 75.97873 0.0006597853 3.641907e-51 2.370957e-48 7 127346790 127347668 879 - 1.576 2.184 2.049
ENSG00000048405 E002 18.02859 0.0018714807 7.944337e-04 3.239900e-03 7 127347669 127348043 375 - 1.131 1.420 1.015
ENSG00000048405 E003 70.14525 0.0021134398 1.586421e-03 5.914799e-03 7 127370043 127371599 1557 - 1.746 1.903 0.531
ENSG00000048405 E004 13.09198 0.0076549128 3.347464e-02 7.872203e-02 7 127371600 127371600 1 - 1.147 0.891 -0.942
ENSG00000048405 E005 33.90448 0.0006768735 4.619813e-03 1.487566e-02 7 127371601 127371814 214 - 1.524 1.317 -0.714
ENSG00000048405 E006 44.46578 0.0006610516 6.713066e-01 7.775700e-01 7 127373342 127373479 138 - 1.590 1.621 0.104
ENSG00000048405 E007 193.56404 0.0015569688 1.982803e-01 3.240673e-01 7 127373480 127374609 1130 - 2.233 2.200 -0.110
ENSG00000048405 E008 83.64774 0.0003882834 5.858521e-06 4.106861e-05 7 127374610 127374945 336 - 1.911 1.702 -0.704
ENSG00000048405 E009 42.17202 0.0005651114 1.117012e-02 3.157483e-02 7 127374946 127375034 89 - 1.611 1.450 -0.551
ENSG00000048405 E010 23.80610 0.0008526764 2.231537e-02 5.633017e-02 7 127377186 127377190 5 - 1.377 1.182 -0.684
ENSG00000048405 E011 40.10362 0.0005535802 3.025429e-05 1.798652e-04 7 127377191 127377329 139 - 1.611 1.317 -1.010
ENSG00000048405 E012 29.78141 0.0008136377 1.214703e-02 3.388518e-02 7 127386060 127386155 96 - 1.469 1.277 -0.669
ENSG00000048405 E013 25.56326 0.0008012005 6.004701e-02 1.266824e-01 7 127391497 127391577 81 - 1.398 1.247 -0.527
ENSG00000048405 E014 15.87531 0.0112823545 7.703966e-02 1.547516e-01 7 127391578 127391615 38 - 1.211 1.011 -0.720
ENSG00000048405 E015 10.35105 0.0176641963 1.726752e-01 2.916828e-01 7 127392060 127392064 5 - 1.039 0.855 -0.690
ENSG00000048405 E016 14.40477 0.0144572775 7.325097e-02 1.487196e-01 7 127392065 127392157 93 - 1.173 0.956 -0.788
ENSG00000048405 E017 11.97978 0.0015633138 7.895822e-02 1.578539e-01 7 127392158 127392258 101 - 1.097 0.892 -0.759
ENSG00000048405 E018 27.17732 0.0009586564 4.977782e-01 6.343124e-01 7 127392259 127392547 289 - 1.401 1.354 -0.162
ENSG00000048405 E019 18.65306 0.0009653967 7.263365e-01 8.194026e-01 7 127392548 127392761 214 - 1.242 1.216 -0.094
ENSG00000048405 E020 0.00000       7 127431869 127431924 56 -