ENSG00000048392

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251810 ENSG00000048392 HEK293_OSMI2_2hA HEK293_TMG_2hB RRM2B protein_coding protein_coding 8.216669 1.532132 15.64571 0.242482 0.4086241 3.34369 6.2821952 1.41583932 11.113544 0.22828733 0.4870132 2.963733 0.81782917 0.9241 0.70966667 -0.21443333 1.134686e-05 1.134686e-05 FALSE TRUE
ENST00000395912 ENSG00000048392 HEK293_OSMI2_2hA HEK293_TMG_2hB RRM2B protein_coding protein_coding 8.216669 1.532132 15.64571 0.242482 0.4086241 3.34369 0.5325891 0.00000000 1.175642 0.00000000 0.2191628 6.889525 0.03498750 0.0000 0.07593333 0.07593333 2.365350e-03 1.134686e-05 FALSE TRUE
ENST00000522368 ENSG00000048392 HEK293_OSMI2_2hA HEK293_TMG_2hB RRM2B protein_coding protein_coding 8.216669 1.532132 15.64571 0.242482 0.4086241 3.34369 0.6772349 0.00000000 1.232657 0.00000000 0.0565524 6.957285 0.04887917 0.0000 0.07906667 0.07906667 2.294855e-04 1.134686e-05 FALSE TRUE
MSTRG.31930.2 ENSG00000048392 HEK293_OSMI2_2hA HEK293_TMG_2hB RRM2B protein_coding   8.216669 1.532132 15.64571 0.242482 0.4086241 3.34369 0.5036834 0.04306033 1.722618 0.02158569 0.3008051 5.029176 0.03975833 0.0287 0.10926667 0.08056667 5.726834e-02 1.134686e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000048392 E001 182.5744052 0.0268062457 1.862856e-12 4.367729e-11 8 102204502 102205777 1276 - 1.913 2.552 2.134
ENSG00000048392 E002 48.4397000 0.0182719835 2.186707e-02 5.540082e-02 8 102205778 102205959 182 - 1.420 1.768 1.187
ENSG00000048392 E003 307.0817741 0.0001912992 2.697610e-02 6.594587e-02 8 102205960 102207744 1785 - 2.245 2.317 0.238
ENSG00000048392 E004 24.6594136 0.0008222229 2.495954e-02 6.178797e-02 8 102207745 102207775 31 - 1.197 1.045 -0.544
ENSG00000048392 E005 65.6183020 0.0003634460 4.426245e-04 1.938415e-03 8 102207776 102208094 319 - 1.603 1.463 -0.478
ENSG00000048392 E006 25.9158718 0.0137370844 9.726091e-02 1.862997e-01 8 102208095 102208132 38 - 1.212 1.124 -0.314
ENSG00000048392 E007 52.4345771 0.0007399211 3.950443e-02 9.011596e-02 8 102208133 102208285 153 - 1.499 1.463 -0.125
ENSG00000048392 E008 51.9528752 0.0012455194 1.798126e-02 4.709236e-02 8 102212776 102212889 114 - 1.498 1.428 -0.240
ENSG00000048392 E009 52.9029992 0.0009777886 3.389802e-01 4.828798e-01 8 102214054 102214158 105 - 1.496 1.554 0.199
ENSG00000048392 E010 0.0000000       8 102214159 102214229 71 -      
ENSG00000048392 E011 56.9691955 0.0004212971 1.007361e-01 1.915810e-01 8 102218814 102218947 134 - 1.532 1.540 0.027
ENSG00000048392 E012 0.4502799 0.0343656896 1.000000e+00 1.000000e+00 8 102218948 102219015 68 - 0.108 0.001 -7.009
ENSG00000048392 E013 48.8555525 0.0018340662 3.143142e-01 4.570293e-01 8 102224046 102224140 95 - 1.463 1.511 0.165
ENSG00000048392 E014 34.7141053 0.0006170774 1.188007e-01 2.182358e-01 8 102224885 102224922 38 - 1.326 1.303 -0.083
ENSG00000048392 E015 59.4007285 0.0004497044 6.382636e-04 2.674034e-03 8 102224923 102225018 96 - 1.559 1.410 -0.512
ENSG00000048392 E016 42.9417474 0.0005250765 8.669163e-03 2.545682e-02 8 102225918 102225974 57 - 1.420 1.303 -0.407
ENSG00000048392 E017 43.6334862 0.0005810754 2.312323e-04 1.096799e-03 8 102225975 102226034 60 - 1.435 1.193 -0.847
ENSG00000048392 E018 48.0586876 0.0004502959 2.415945e-06 1.845910e-05 8 102232149 102232230 82 - 1.482 1.125 -1.250
ENSG00000048392 E019 42.0984281 0.0004862605 1.074627e-06 8.859223e-06 8 102232231 102232304 74 - 1.431 0.999 -1.532
ENSG00000048392 E020 0.0000000       8 102234725 102234845 121 -      
ENSG00000048392 E021 0.8889184 0.0134223006 6.259524e-01 7.419666e-01 8 102238441 102238558 118 - 0.168 0.327 1.248
ENSG00000048392 E022 4.8694772 0.0033448657 1.119981e-01 2.084820e-01 8 102238559 102238826 268 - 0.604 0.327 -1.429
ENSG00000048392 E023 31.6954372 0.0006861451 1.009972e-08 1.243816e-07 8 102238827 102238961 135 - 1.322 0.511 -3.157