ENSG00000048342

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000506643 ENSG00000048342 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D2A protein_coding protein_coding 4.756097 7.129219 4.891213 0.2050888 0.3011944 -0.5426274 1.3534816 1.0339834 2.13690050 0.08244018 0.16809771 1.0401565 0.3043208 0.14573333 0.436133333 0.290400000 8.198237e-11 8.198237e-11 FALSE TRUE
ENST00000514039 ENSG00000048342 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D2A protein_coding protein_coding 4.756097 7.129219 4.891213 0.2050888 0.3011944 -0.5426274 0.1517383 0.5205289 0.03458486 0.26206432 0.03458486 -3.5728055 0.0279000 0.07253333 0.006933333 -0.065600000 4.578124e-01 8.198237e-11 FALSE TRUE
ENST00000514450 ENSG00000048342 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D2A protein_coding protein_coding 4.756097 7.129219 4.891213 0.2050888 0.3011944 -0.5426274 0.5165145 0.9388931 0.47808110 0.09896174 0.04395788 -0.9591247 0.1030917 0.13120000 0.097633333 -0.033566667 4.739792e-01 8.198237e-11 FALSE TRUE
ENST00000515124 ENSG00000048342 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D2A protein_coding protein_coding 4.756097 7.129219 4.891213 0.2050888 0.3011944 -0.5426274 0.2950902 0.5031395 0.35148957 0.14793636 0.19944375 -0.5053969 0.0574750 0.06953333 0.075800000 0.006266667 9.046026e-01 8.198237e-11 FALSE FALSE
ENST00000652443 ENSG00000048342 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D2A protein_coding protein_coding 4.756097 7.129219 4.891213 0.2050888 0.3011944 -0.5426274 2.0206768 3.9753999 1.34321558 0.14050358 0.36188217 -1.5583328 0.4043958 0.55883333 0.267333333 -0.291500000 1.166364e-02 8.198237e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000048342 E001 0.2214452 0.0398682631 4.221441e-01   4 15469865 15469870 6 + 0.000 0.132 10.109
ENSG00000048342 E002 0.2214452 0.0398682631 4.221441e-01   4 15469871 15469881 11 + 0.000 0.132 12.844
ENSG00000048342 E003 1.1844461 0.1401853419 8.933413e-01 9.358349e-01 4 15469882 15469895 14 + 0.341 0.317 -0.153
ENSG00000048342 E004 1.1844461 0.1401853419 8.933413e-01 9.358349e-01 4 15469896 15469902 7 + 0.341 0.317 -0.153
ENSG00000048342 E005 1.8089417 0.1719153777 9.404431e-01 9.666120e-01 4 15469903 15469905 3 + 0.446 0.444 -0.008
ENSG00000048342 E006 3.0643894 0.0196697591 9.331166e-01 9.618431e-01 4 15469906 15469920 15 + 0.601 0.622 0.094
ENSG00000048342 E007 5.5879571 0.0382859016 8.458367e-01 9.041275e-01 4 15469921 15470012 92 + 0.805 0.844 0.152
ENSG00000048342 E008 4.7013305 0.0134672794 8.447158e-01 9.033653e-01 4 15470013 15470057 45 + 0.739 0.775 0.146
ENSG00000048342 E009 0.4847352 0.2163769918 7.101469e-01 8.073648e-01 4 15473222 15473255 34 + 0.204 0.132 -0.753
ENSG00000048342 E010 7.0585193 0.0049674729 2.942783e-01 4.353881e-01 4 15475915 15475971 57 + 0.844 0.977 0.507
ENSG00000048342 E011 7.7463759 0.0772644787 5.957406e-01 7.177918e-01 4 15478723 15478806 84 + 0.896 0.999 0.386
ENSG00000048342 E012 0.9932149 0.0377607088 7.031013e-02 1.438695e-01 4 15479204 15479215 12 + 0.114 0.442 2.565
ENSG00000048342 E013 0.9932149 0.0377607088 7.031013e-02 1.438695e-01 4 15479216 15479218 3 + 0.114 0.442 2.565
ENSG00000048342 E014 1.3221683 0.0886495063 1.451614e-01 2.550583e-01 4 15479219 15479222 4 + 0.204 0.494 1.824
ENSG00000048342 E015 34.0139779 0.0010641872 2.151077e-04 1.028883e-03 4 15479223 15479328 106 + 1.406 1.639 0.798
ENSG00000048342 E016 37.3355472 0.0013583528 4.579815e-06 3.289227e-05 4 15480704 15480727 24 + 1.417 1.696 0.954
ENSG00000048342 E017 59.7176420 0.0004802459 3.728866e-07 3.383250e-06 4 15480728 15480827 100 + 1.644 1.882 0.806
ENSG00000048342 E018 86.9475019 0.0039033646 5.924759e-28 8.357616e-26 4 15481197 15482259 1063 + 1.600 2.135 1.803
ENSG00000048342 E019 15.7883119 0.0185923026 2.255455e-01 3.570622e-01 4 15502429 15502517 89 + 1.277 1.153 -0.436
ENSG00000048342 E020 14.7533639 0.0012812360 8.925394e-01 9.353505e-01 4 15502822 15502923 102 + 1.194 1.191 -0.009
ENSG00000048342 E021 17.2177868 0.0044318317 5.139904e-01 6.487574e-01 4 15510139 15510240 102 + 1.277 1.230 -0.165
ENSG00000048342 E022 22.6333991 0.0008274666 8.420198e-01 9.014870e-01 4 15511247 15511423 177 + 1.364 1.387 0.082
ENSG00000048342 E023 7.3265335 0.0026265227 1.349204e-04 6.808081e-04 4 15511424 15511672 249 + 0.632 1.103 1.831
ENSG00000048342 E024 14.3332792 0.0013540859 1.282438e-01 2.316982e-01 4 15514707 15514869 163 + 1.241 1.116 -0.446
ENSG00000048342 E025 18.3546163 0.0020567179 5.737679e-02 1.221237e-01 4 15515868 15516004 137 + 1.346 1.202 -0.508
ENSG00000048342 E026 12.6798180 0.0260140129 7.956960e-03 2.366737e-02 4 15516625 15516756 132 + 1.263 0.947 -1.140
ENSG00000048342 E027 13.8454947 0.0183836537 5.776082e-05 3.204186e-04 4 15527447 15527618 172 + 1.340 0.890 -1.627
ENSG00000048342 E028 7.5053566 0.0122358373 1.403210e-03 5.316893e-03 4 15527619 15527656 38 + 1.091 0.690 -1.542
ENSG00000048342 E029 10.8183748 0.0090110488 5.268672e-03 1.666251e-02 4 15528620 15528726 107 + 1.202 0.907 -1.077
ENSG00000048342 E030 13.6514033 0.0012737425 4.021190e-03 1.320098e-02 4 15533193 15533333 141 + 1.277 1.024 -0.905
ENSG00000048342 E031 0.0000000       4 15533334 15533453 120 +      
ENSG00000048342 E032 16.8732167 0.0187005737 1.722163e-03 6.352140e-03 4 15536920 15537076 157 + 1.386 1.065 -1.136
ENSG00000048342 E033 15.4234852 0.0024332940 3.578086e-02 8.315565e-02 4 15537899 15538055 157 + 1.291 1.116 -0.619
ENSG00000048342 E034 11.1743205 0.0021234698 4.491468e-02 1.000441e-01 4 15538056 15538137 82 + 1.169 0.978 -0.691
ENSG00000048342 E035 3.0538940 0.0051480918 9.266229e-01 9.577864e-01 4 15538843 15540276 1434 + 0.601 0.622 0.095
ENSG00000048342 E036 8.1108772 0.0080914738 2.736943e-03 9.483760e-03 4 15540837 15540906 70 + 1.102 0.749 -1.339
ENSG00000048342 E037 8.9057255 0.0020291458 1.184485e-03 4.588337e-03 4 15540907 15541014 108 + 1.132 0.776 -1.337
ENSG00000048342 E038 0.0000000       4 15543579 15543961 383 +      
ENSG00000048342 E039 0.0000000       4 15550738 15550823 86 +      
ENSG00000048342 E040 11.8728425 0.0035186997 5.672648e-05 3.152253e-04 4 15550824 15550980 157 + 1.270 0.868 -1.466
ENSG00000048342 E041 11.7360133 0.0015300093 3.922057e-04 1.744797e-03 4 15553158 15553305 148 + 1.249 0.908 -1.239
ENSG00000048342 E042 10.2676481 0.0022561445 2.421290e-02 6.025063e-02 4 15555072 15555210 139 + 1.151 0.927 -0.820
ENSG00000048342 E043 11.4397860 0.0126199391 9.596917e-02 1.843361e-01 4 15557304 15557458 155 + 1.169 0.995 -0.630
ENSG00000048342 E044 8.3249580 0.0071896193 1.059807e-01 1.995857e-01 4 15557459 15557507 49 + 1.048 0.868 -0.670
ENSG00000048342 E045 10.5890968 0.0016393615 2.089725e-01 3.372883e-01 4 15559165 15559257 93 + 1.112 0.994 -0.430
ENSG00000048342 E046 10.3205122 0.0017150036 4.426004e-02 9.886375e-02 4 15560531 15560622 92 + 1.141 0.945 -0.719
ENSG00000048342 E047 0.7708142 0.0152702638 2.261426e-01 3.577802e-01 4 15560623 15561587 965 + 0.341 0.132 -1.752
ENSG00000048342 E048 0.1515154 0.0428061468 5.605341e-01   4 15561588 15561602 15 + 0.114 0.000 -13.516
ENSG00000048342 E049 1.9335050 0.0122481475 2.030047e-02 5.211196e-02 4 15561603 15563309 1707 + 0.632 0.232 -2.215
ENSG00000048342 E050 0.6028395 0.4805011537 6.067955e-01 7.268678e-01 4 15563310 15563354 45 + 0.279 0.129 -1.384
ENSG00000048342 E051 12.6315778 0.0036399011 2.238848e-01 3.550562e-01 4 15563355 15563522 168 + 1.186 1.079 -0.383
ENSG00000048342 E052 12.1252006 0.0015384064 6.035006e-02 1.272060e-01 4 15567377 15567482 106 + 1.194 1.024 -0.612
ENSG00000048342 E053 15.6560036 0.0016495339 7.256116e-02 1.476134e-01 4 15567677 15567786 110 + 1.284 1.139 -0.513
ENSG00000048342 E054 18.3748050 0.0011659248 1.659959e-02 4.406006e-02 4 15569293 15569389 97 + 1.364 1.182 -0.639
ENSG00000048342 E055 16.2375997 0.0016857101 1.987707e-02 5.122917e-02 4 15570398 15570496 99 + 1.316 1.128 -0.667
ENSG00000048342 E056 16.7185450 0.0011597762 9.296184e-02 1.797626e-01 4 15574150 15574326 177 + 1.310 1.181 -0.453
ENSG00000048342 E057 0.0000000       4 15576604 15576624 21 +      
ENSG00000048342 E058 0.0000000       4 15576625 15577094 470 +      
ENSG00000048342 E059 17.9413304 0.0247116764 8.162189e-01 8.837160e-01 4 15579968 15580171 204 + 1.290 1.265 -0.087
ENSG00000048342 E060 0.0000000       4 15580172 15580534 363 +      
ENSG00000048342 E061 15.1941569 0.0014146554 1.818639e-01 3.035690e-01 4 15586157 15586246 90 + 1.256 1.150 -0.376
ENSG00000048342 E062 18.2908683 0.0010362665 7.069643e-02 1.445011e-01 4 15587816 15587929 114 + 1.352 1.220 -0.464
ENSG00000048342 E063 16.4837042 0.0011358321 3.487805e-01 4.930045e-01 4 15589545 15589679 135 + 1.202 1.288 0.303
ENSG00000048342 E064 0.8449086 0.0144629278 1.259017e-01 2.284295e-01 4 15590764 15591676 913 + 0.114 0.383 2.247
ENSG00000048342 E065 0.1472490 0.0434292294 5.605251e-01   4 15595872 15596084 213 + 0.114 0.000 -13.513
ENSG00000048342 E066 8.7013095 0.0139993752 1.499738e-01 2.616359e-01 4 15596085 15596143 59 + 0.896 1.077 0.670
ENSG00000048342 E067 9.3226584 0.0496074035 3.709237e-01 5.153449e-01 4 15596144 15596207 64 + 0.942 1.085 0.527
ENSG00000048342 E068 11.1664745 0.0167250563 9.739415e-01 9.877432e-01 4 15597407 15597465 59 + 1.081 1.091 0.037
ENSG00000048342 E069 18.6920560 0.0290619182 4.926232e-01 6.297639e-01 4 15599529 15599706 178 + 1.255 1.337 0.287
ENSG00000048342 E070 1.4684618 0.0110605721 4.387484e-01 5.805939e-01 4 15599707 15600887 1181 + 0.446 0.315 -0.751
ENSG00000048342 E071 19.4482808 0.0020642151 5.213200e-02 1.129541e-01 4 15601237 15601552 316 + 1.226 1.387 0.563