ENSG00000047578

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261588 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding protein_coding 6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 1.2858220 0.6487796 0.8715622 0.25829552 0.2098273 0.42026651 0.21193750 0.07343333 0.22060000 0.14716667 0.05538518 0.00572012 FALSE TRUE
ENST00000568622 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding retained_intron 6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 2.1484456 3.6156901 0.6158743 0.69812820 0.1182974 -2.53431070 0.28970000 0.41503333 0.15676667 -0.25826667 0.00572012 0.00572012 FALSE TRUE
ENST00000618117 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding protein_coding 6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.6386231 1.7151245 0.3344489 0.32865733 0.1865149 -2.32433866 0.08601250 0.20043333 0.08066667 -0.11976667 0.41596431 0.00572012 FALSE FALSE
MSTRG.12333.1 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding   6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.3794485 0.8073654 0.7939309 0.28776810 0.3987253 -0.02390965 0.07162083 0.09270000 0.21923333 0.12653333 0.88172767 0.00572012 FALSE TRUE
MSTRG.12333.3 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding   6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.2388377 0.2849724 0.4309757 0.07297225 0.2449886 0.58011932 0.04116250 0.03256667 0.10776667 0.07520000 0.77102993 0.00572012 FALSE TRUE
MSTRG.12333.5 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding   6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.4363660 0.5536183 0.2283753 0.55361829 0.2283753 -1.24148385 0.07404167 0.07060000 0.05266667 -0.01793333 0.95059980 0.00572012 FALSE TRUE
MSTRG.12333.6 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding   6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.6187917 0.5477295 0.2088679 0.37839193 0.1164685 -1.34950477 0.10845833 0.06786667 0.05036667 -0.01750000 1.00000000 0.00572012 FALSE TRUE
MSTRG.12333.7 ENSG00000047578 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNIP protein_coding   6.486699 8.595465 3.874092 0.3778731 0.2581003 -1.147676 0.3602748 0.3862272 0.2733141 0.38622724 0.2733141 -0.48392571 0.05372500 0.04313333 0.07936667 0.03623333 0.98065783 0.00572012 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047578 E001 0.8513531 0.0174936042 3.633777e-01 5.077879e-01 16 27550105 27550132 28 + 0.334 0.190 -1.078
ENSG00000047578 E002 0.8513531 0.0174936042 3.633777e-01 5.077879e-01 16 27550133 27550143 11 + 0.334 0.190 -1.078
ENSG00000047578 E003 1.0727983 0.0388356281 6.203295e-01 7.375304e-01 16 27550144 27550148 5 + 0.334 0.262 -0.487
ENSG00000047578 E004 3.2755532 0.0744141462 3.345674e-01 4.783066e-01 16 27550149 27550157 9 + 0.687 0.547 -0.616
ENSG00000047578 E005 11.9801733 0.0016093418 7.609650e-02 1.532649e-01 16 27550158 27550177 20 + 1.173 1.036 -0.494
ENSG00000047578 E006 14.8511257 0.0012250178 4.141636e-01 5.575717e-01 16 27573901 27573906 6 + 1.206 1.168 -0.136
ENSG00000047578 E007 16.3592518 0.0011442543 6.428690e-01 7.555565e-01 16 27573907 27573921 15 + 1.226 1.221 -0.019
ENSG00000047578 E008 18.7113309 0.0009866465 6.011411e-01 7.222775e-01 16 27573922 27573956 35 + 1.282 1.275 -0.027
ENSG00000047578 E009 0.0000000       16 27573957 27574295 339 +      
ENSG00000047578 E010 21.8621294 0.0008707733 3.703799e-01 5.148183e-01 16 27618425 27618469 45 + 1.273 1.376 0.357
ENSG00000047578 E011 20.9158834 0.0009717481 7.480250e-01 8.353860e-01 16 27618470 27618501 32 + 1.291 1.350 0.205
ENSG00000047578 E012 0.2998086 0.0296763650 7.550822e-01   16 27628588 27628660 73 + 0.142 0.105 -0.498
ENSG00000047578 E013 40.4951864 0.0005729008 4.608585e-01 6.008455e-01 16 27628661 27628830 170 + 1.554 1.630 0.261
ENSG00000047578 E014 29.9139417 0.0006874443 7.761264e-01 8.558438e-01 16 27631065 27631162 98 + 1.465 1.482 0.057
ENSG00000047578 E015 3.8620660 0.0531615899 2.387817e-01 3.727340e-01 16 27631163 27631254 92 + 0.521 0.751 1.001
ENSG00000047578 E016 0.1472490 0.0431416324 3.262052e-01   16 27632464 27632603 140 + 0.142 0.000 -10.650
ENSG00000047578 E017 16.3823300 0.0170627235 3.953827e-01 5.391898e-01 16 27648604 27648735 132 + 1.246 1.197 -0.174
ENSG00000047578 E018 13.0719768 0.0399486188 5.492396e-01 6.789943e-01 16 27654608 27654736 129 + 1.043 1.168 0.453
ENSG00000047578 E019 42.0224942 0.0006378622 3.319269e-01 4.755545e-01 16 27677729 27677996 268 + 1.623 1.605 -0.062
ENSG00000047578 E020 27.9244919 0.0168308302 1.437771e-01 2.531496e-01 16 27681399 27681530 132 + 1.493 1.403 -0.310
ENSG00000047578 E021 24.3798010 0.0017229700 3.867983e-02 8.858853e-02 16 27698328 27698500 173 + 1.448 1.334 -0.393
ENSG00000047578 E022 10.9900643 0.0023085381 1.210066e-01 2.213736e-01 16 27699534 27699599 66 + 1.126 1.003 -0.449
ENSG00000047578 E023 0.1515154 0.0432678610 3.258683e-01   16 27701434 27701588 155 + 0.142 0.000 -10.650
ENSG00000047578 E024 16.7583168 0.0145745326 2.814055e-01 4.213076e-01 16 27701589 27701695 107 + 1.283 1.212 -0.250
ENSG00000047578 E025 18.1108671 0.0106811152 5.074926e-02 1.105040e-01 16 27703896 27703998 103 + 1.355 1.212 -0.500
ENSG00000047578 E026 11.9192797 0.0105664600 6.280117e-02 1.313769e-01 16 27708705 27708713 9 + 1.195 1.035 -0.577
ENSG00000047578 E027 28.1463550 0.0008832757 4.304140e-04 1.891411e-03 16 27708714 27708920 207 + 1.563 1.371 -0.661
ENSG00000047578 E028 24.9304189 0.0008046776 3.496228e-02 8.158453e-02 16 27721558 27721695 138 + 1.465 1.355 -0.381
ENSG00000047578 E029 0.7749789 0.0154496996 9.806447e-01 9.918805e-01 16 27727216 27727873 658 + 0.249 0.260 0.088
ENSG00000047578 E030 84.8663954 0.0032498620 3.238733e-03 1.096890e-02 16 27740041 27740920 880 + 1.972 1.876 -0.322
ENSG00000047578 E031 68.5236770 0.0048801145 1.085539e-01 2.034085e-01 16 27749584 27750306 723 + 1.853 1.804 -0.165
ENSG00000047578 E032 33.8378128 0.0006304703 2.694504e-01 4.079614e-01 16 27751719 27751924 206 + 1.544 1.512 -0.108
ENSG00000047578 E033 19.3208863 0.0010223242 5.932087e-01 7.156538e-01 16 27754173 27754251 79 + 1.246 1.322 0.268
ENSG00000047578 E034 0.5181333 0.0206829589 3.497112e-01 4.939111e-01 16 27754252 27755752 1501 + 0.249 0.105 -1.493
ENSG00000047578 E035 32.6408554 0.0006272595 9.353831e-01 9.633300e-01 16 27761413 27761590 178 + 1.493 1.523 0.102
ENSG00000047578 E036 29.9755803 0.0006917380 6.639354e-01 7.718730e-01 16 27766309 27766474 166 + 1.471 1.478 0.024
ENSG00000047578 E037 32.9984886 0.0006707676 3.460584e-01 4.902101e-01 16 27769861 27770018 158 + 1.524 1.501 -0.079
ENSG00000047578 E038 23.1744326 0.0008743925 7.597258e-03 2.276402e-02 16 27771588 27771652 65 + 1.460 1.305 -0.536
ENSG00000047578 E039 28.8750762 0.0106629256 5.520715e-01 6.814458e-01 16 27773099 27773209 111 + 1.471 1.460 -0.040
ENSG00000047578 E040 38.8360727 0.0055431257 2.540440e-01 3.906755e-01 16 27774945 27775084 140 + 1.514 1.626 0.383
ENSG00000047578 E041 5.8887283 0.0727613911 8.082951e-01 8.782049e-01 16 27776866 27776927 62 + 0.751 0.842 0.357
ENSG00000047578 E042 34.7588762 0.0009387226 2.731766e-01 4.121766e-01 16 27776928 27777029 102 + 1.471 1.574 0.351
ENSG00000047578 E043 45.3283164 0.0008253999 5.624253e-01 6.900220e-01 16 27777610 27777770 161 + 1.606 1.673 0.225
ENSG00000047578 E044 44.8711646 0.0119824460 7.740295e-01 8.542823e-01 16 27777881 27777969 89 + 1.606 1.663 0.194
ENSG00000047578 E045 269.3145737 0.0119925630 4.471408e-06 3.219301e-05 16 27778574 27780344 1771 + 2.233 2.496 0.879