ENSG00000047315

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314595 ENSG00000047315 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2B protein_coding protein_coding 68.73538 19.6229 112.5424 1.281425 3.867413 2.519251 48.964167 13.101963 80.286385 0.4272200 1.887716 2.614451 0.68345417 0.67143333 0.71396667 0.04253333 6.380542e-01 4.457468e-19 FALSE  
ENST00000431623 ENSG00000047315 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2B protein_coding protein_coding 68.73538 19.6229 112.5424 1.281425 3.867413 2.519251 3.693226 1.906423 4.377004 0.6909761 0.504039 1.194820 0.05674167 0.09356667 0.03866667 -0.05490000 1.027221e-01 4.457468e-19 FALSE  
ENST00000450656 ENSG00000047315 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2B protein_coding protein_coding 68.73538 19.6229 112.5424 1.281425 3.867413 2.519251 3.675336 0.000000 9.425827 0.0000000 1.398472 9.882005 0.03190833 0.00000000 0.08353333 0.08353333 4.457468e-19 4.457468e-19    
ENST00000484821 ENSG00000047315 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2B protein_coding retained_intron 68.73538 19.6229 112.5424 1.281425 3.867413 2.519251 7.853947 3.129405 10.855926 0.3157293 1.471534 1.791248 0.14199583 0.15900000 0.09610000 -0.06290000 2.326548e-02 4.457468e-19    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047315 E001 1.9522681 0.1887657944 9.543953e-01 9.754329e-01 4 56976440 56977566 1127 + 0.417 0.386 -0.171
ENSG00000047315 E002 1.6305759 0.0084338240 7.992407e-02 1.594433e-01 4 56977672 56977721 50 + 0.417 0.000 -11.833
ENSG00000047315 E003 2.6646524 0.0063325127 5.154752e-01 6.501540e-01 4 56977722 56977741 20 + 0.505 0.388 -0.608
ENSG00000047315 E004 5.7710770 0.0037059193 8.348025e-01 8.965823e-01 4 56977742 56977781 40 + 0.744 0.727 -0.070
ENSG00000047315 E005 5.6226821 0.0043166266 7.694560e-01 8.511089e-01 4 56977782 56977791 10 + 0.721 0.782 0.248
ENSG00000047315 E006 2.9819645 0.0053732239 6.958296e-01 7.963184e-01 4 56977792 56977808 17 + 0.505 0.590 0.392
ENSG00000047315 E007 1.4705251 0.1614130869 3.056440e-01 4.477645e-01 4 56977809 56978000 192 + 0.274 0.504 1.319
ENSG00000047315 E008 15.4560438 0.0011097317 1.883256e-01 3.116230e-01 4 56978640 56978863 224 + 1.148 1.016 -0.477
ENSG00000047315 E009 6.3342789 0.0026603544 1.443503e-01 2.539347e-01 4 56978864 56978868 5 + 0.818 0.590 -0.950
ENSG00000047315 E010 43.3529908 0.0047497068 2.000685e-06 1.556374e-05 4 56978869 56978895 27 + 1.604 1.189 -1.439
ENSG00000047315 E011 52.4739296 0.0022868871 1.539449e-08 1.832510e-07 4 56978896 56978903 8 + 1.688 1.246 -1.522
ENSG00000047315 E012 291.4739293 0.0051395579 9.401488e-11 1.666277e-09 4 56978904 56979004 101 + 2.411 2.116 -0.984
ENSG00000047315 E013 2.0294591 0.0073102475 8.381986e-01 8.988394e-01 4 56985260 56985279 20 + 0.417 0.388 -0.160
ENSG00000047315 E014 3.8010550 0.0041194035 1.726594e-01 2.916682e-01 4 56985280 56985457 178 + 0.641 0.388 -1.225
ENSG00000047315 E015 315.1534446 0.0085004629 4.500424e-06 3.237731e-05 4 56986354 56986426 73 + 2.438 2.203 -0.785
ENSG00000047315 E016 0.0000000       4 56986427 56986803 377 +      
ENSG00000047315 E017 351.6772263 0.0075507264 1.366141e-05 8.793836e-05 4 56990748 56990898 151 + 2.482 2.275 -0.691
ENSG00000047315 E018 0.0000000       4 56990899 56990906 8 +      
ENSG00000047315 E019 290.2457541 0.0100934048 9.837954e-05 5.143281e-04 4 56994404 56994516 113 + 2.400 2.185 -0.717
ENSG00000047315 E020 408.8432896 0.0002266882 3.735133e-23 3.365495e-21 4 56994647 56994866 220 + 2.552 2.314 -0.793
ENSG00000047315 E021 339.5870743 0.0150333258 2.528578e-04 1.187250e-03 4 56995251 56995409 159 + 2.470 2.248 -0.743
ENSG00000047315 E022 348.2989902 0.0064002175 5.686815e-06 3.995901e-05 4 56999617 56999781 165 + 2.478 2.282 -0.656
ENSG00000047315 E023 384.3397660 0.0003758236 2.829226e-09 3.859641e-08 4 57005246 57005442 197 + 2.512 2.377 -0.451
ENSG00000047315 E024 301.1795728 0.0001700708 6.247443e-05 3.435985e-04 4 57005600 57005719 120 + 2.398 2.308 -0.302
ENSG00000047315 E025 447.7948857 0.0001520592 1.015270e-06 8.409403e-06 4 57006816 57007002 187 + 2.569 2.478 -0.305
ENSG00000047315 E026 16.9077127 0.0115246347 1.878902e-02 4.887174e-02 4 57009559 57010172 614 + 1.204 0.915 -1.055
ENSG00000047315 E027 4.1553807 0.0039903155 1.103574e-01 2.060658e-01 4 57010173 57010200 28 + 0.683 0.388 -1.403
ENSG00000047315 E028 8.2417475 0.0164840561 9.149100e-02 1.774600e-01 4 57010201 57010360 160 + 0.921 0.663 -1.029
ENSG00000047315 E029 415.4771254 0.0003639886 8.369343e-07 7.069498e-06 4 57010361 57010504 144 + 2.539 2.436 -0.343
ENSG00000047315 E030 341.0744982 0.0004240817 1.223012e-03 4.718571e-03 4 57010748 57010887 140 + 2.448 2.380 -0.228
ENSG00000047315 E031 401.0085934 0.0011322637 9.847997e-04 3.907170e-03 4 57010989 57011100 112 + 2.520 2.443 -0.255
ENSG00000047315 E032 494.6077189 0.0005091417 2.852199e-03 9.829890e-03 4 57015502 57015656 155 + 2.606 2.555 -0.169
ENSG00000047315 E033 0.1515154 0.0434557688 1.000000e+00   4 57015657 57015658 2 + 0.059 0.000 -8.374
ENSG00000047315 E034 564.0370907 0.0020812176 7.961144e-01 8.698311e-01 4 57017043 57017241 199 + 2.651 2.660 0.030
ENSG00000047315 E035 513.8508125 0.0008097426 7.261047e-01 8.192142e-01 4 57017560 57017728 169 + 2.611 2.622 0.036
ENSG00000047315 E036 391.1451773 0.0001714390 1.304052e-01 2.347223e-01 4 57020899 57020995 97 + 2.483 2.537 0.179
ENSG00000047315 E037 238.9895621 0.0034495289 4.289005e-02 9.633862e-02 4 57022152 57022182 31 + 2.260 2.358 0.328
ENSG00000047315 E038 346.6431412 0.0001561899 5.032900e-01 6.392549e-01 4 57022183 57022246 64 + 2.442 2.445 0.011
ENSG00000047315 E039 1.4854032 0.0091573414 1.012466e-01 1.923664e-01 4 57023227 57023329 103 + 0.392 0.000 -11.696
ENSG00000047315 E040 558.0378634 0.0003725318 1.943930e-01 3.192757e-01 4 57023330 57023490 161 + 2.640 2.685 0.152
ENSG00000047315 E041 427.3522542 0.0007017692 2.067241e-04 9.928073e-04 4 57023491 57023580 90 + 2.511 2.618 0.359
ENSG00000047315 E042 31.7568599 0.0006591929 4.053597e-01 5.490514e-01 4 57023581 57023661 81 + 1.404 1.486 0.280
ENSG00000047315 E043 409.8634936 0.0011948407 5.337042e-06 3.773556e-05 4 57023662 57023751 90 + 2.486 2.625 0.464
ENSG00000047315 E044 442.9564447 0.0005385392 7.952474e-14 2.294506e-12 4 57024005 57024112 108 + 2.507 2.693 0.617
ENSG00000047315 E045 516.1163528 0.0002027361 7.759029e-15 2.594290e-13 4 57024886 57024999 114 + 2.578 2.747 0.560
ENSG00000047315 E046 614.3643107 0.0025963417 2.198217e-08 2.543801e-07 4 57025377 57025537 161 + 2.649 2.833 0.613
ENSG00000047315 E047 656.9328291 0.0063894915 2.376641e-10 3.927148e-09 4 57030204 57030399 196 + 2.649 2.930 0.936
ENSG00000047315 E048 350.6011778 0.0110062218 3.332165e-12 7.508846e-11 4 57030899 57031337 439 + 2.332 2.742 1.367