ENSG00000047249

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355221 ENSG00000047249 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1H protein_coding protein_coding 21.91646 18.76997 26.30316 1.917346 0.4382444 0.4865898 3.4204052 2.7242974 3.988477 0.7899969 0.3364194 0.5482804 0.15251250 0.14086667 0.1515333 0.01066667 9.089613e-01 4.123273e-21 FALSE TRUE
ENST00000359530 ENSG00000047249 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1H protein_coding protein_coding 21.91646 18.76997 26.30316 1.917346 0.4382444 0.4865898 12.7493611 12.1139350 14.965790 0.7029137 0.3660452 0.3047741 0.59563750 0.66496667 0.5696333 -0.09533333 6.370060e-01 4.123273e-21 FALSE TRUE
ENST00000396774 ENSG00000047249 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1H protein_coding protein_coding 21.91646 18.76997 26.30316 1.917346 0.4382444 0.4865898 1.6855799 0.7814803 2.573363 0.2950960 0.1720535 1.7066248 0.06982500 0.03993333 0.0981000 0.05816667 4.432000e-02 4.123273e-21 FALSE TRUE
ENST00000520188 ENSG00000047249 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1H protein_coding protein_coding 21.91646 18.76997 26.30316 1.917346 0.4382444 0.4865898 0.9822718 2.0232011 0.000000 1.0789604 0.0000000 -7.6676091 0.04795833 0.10003333 0.0000000 -0.10003333 1.158555e-01 4.123273e-21 FALSE TRUE
ENST00000524164 ENSG00000047249 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1H protein_coding nonsense_mediated_decay 21.91646 18.76997 26.30316 1.917346 0.4382444 0.4865898 1.4984561 0.0000000 3.877808 0.0000000 0.5947466 8.6028131 0.05601250 0.00000000 0.1470667 0.14706667 4.123273e-21 4.123273e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047249 E001 0.0000000       8 53715543 53715556 14 -      
ENSG00000047249 E002 4.3927699 0.1025914265 1.852834e-02 4.829418e-02 8 53715557 53715669 113 - 0.447 0.903 1.964
ENSG00000047249 E003 4.2057801 0.0113882981 9.015948e-04 3.619295e-03 8 53715670 53715672 3 - 0.397 0.906 2.238
ENSG00000047249 E004 10.1162581 0.0179078554 4.271237e-03 1.390284e-02 8 53715673 53715682 10 - 0.844 1.196 1.297
ENSG00000047249 E005 15.6548265 0.0158060031 2.658654e-06 2.013730e-05 8 53715683 53715730 48 - 0.897 1.417 1.866
ENSG00000047249 E006 120.7100951 0.0078568269 4.067024e-04 1.800536e-03 8 53715731 53715899 169 - 1.981 2.174 0.648
ENSG00000047249 E007 197.2433539 0.0063176204 2.164921e-04 1.034709e-03 8 53715900 53716024 125 - 2.203 2.377 0.578
ENSG00000047249 E008 0.0000000       8 53739553 53739623 71 -      
ENSG00000047249 E009 88.8982037 0.0035892175 1.822814e-03 6.672848e-03 8 53743577 53743586 10 - 1.873 2.025 0.510
ENSG00000047249 E010 203.8789969 0.0014151704 6.331752e-07 5.488516e-06 8 53743587 53743690 104 - 2.230 2.384 0.513
ENSG00000047249 E011 0.1515154 0.0424744975 5.719763e-01   8 53743691 53743715 25 - 0.114 0.000 -10.344
ENSG00000047249 E012 1.0393871 0.0376037676 8.481407e-01 9.057276e-01 8 53756262 53756554 293 - 0.278 0.315 0.245
ENSG00000047249 E013 238.5790369 0.0017990885 6.627487e-05 3.620826e-04 8 53756555 53756656 102 - 2.315 2.437 0.406
ENSG00000047249 E014 194.1971351 0.0006303127 2.513091e-03 8.803578e-03 8 53769618 53769653 36 - 2.247 2.334 0.289
ENSG00000047249 E015 206.4004135 0.0002138411 1.578382e-03 5.888651e-03 8 53769654 53769743 90 - 2.277 2.359 0.274
ENSG00000047249 E016 279.5697419 0.0001569255 1.938743e-01 3.186503e-01 8 53771989 53772167 179 - 2.435 2.466 0.105
ENSG00000047249 E017 181.4996314 0.0003148436 8.369806e-01 8.980458e-01 8 53795647 53795749 103 - 2.265 2.263 -0.004
ENSG00000047249 E018 144.5170497 0.0006378657 4.493174e-01 5.905046e-01 8 53795750 53795839 90 - 2.174 2.154 -0.067
ENSG00000047249 E019 161.3273626 0.0020919731 2.249343e-01 3.563430e-01 8 53801799 53801896 98 - 2.231 2.191 -0.133
ENSG00000047249 E020 0.4482035 0.0291351358 1.142357e-01 2.117201e-01 8 53806742 53806858 117 - 0.278 0.000 -11.929
ENSG00000047249 E021 110.6269824 0.0032888374 4.322012e-01 5.746502e-01 8 53811164 53811217 54 - 2.063 2.030 -0.111
ENSG00000047249 E022 82.4631047 0.0003759958 8.396299e-02 1.657483e-01 8 53814662 53814674 13 - 1.954 1.891 -0.212
ENSG00000047249 E023 140.7631232 0.0019299484 3.664878e-03 1.219568e-02 8 53814675 53814731 57 - 2.201 2.098 -0.345
ENSG00000047249 E024 117.6124548 0.0006452676 4.671371e-04 2.034290e-03 8 53814732 53814766 35 - 2.130 2.014 -0.388
ENSG00000047249 E025 180.8909770 0.0029714743 1.295704e-02 3.581112e-02 8 53817417 53817530 114 - 2.304 2.212 -0.305
ENSG00000047249 E026 78.0390764 0.0003856221 1.004675e-01 1.911796e-01 8 53829444 53829445 2 - 1.930 1.868 -0.207
ENSG00000047249 E027 145.3901526 0.0014313359 2.017298e-02 5.184582e-02 8 53829446 53829533 88 - 2.205 2.130 -0.251
ENSG00000047249 E028 0.4482035 0.0291351358 1.142357e-01 2.117201e-01 8 53831789 53832864 1076 - 0.278 0.000 -11.929
ENSG00000047249 E029 0.6727692 0.0611607433 8.788458e-01 9.261642e-01 8 53832865 53832983 119 - 0.204 0.233 0.241
ENSG00000047249 E030 90.5892949 0.0039934419 3.191133e-01 4.621491e-01 8 53832984 53833009 26 - 1.986 1.939 -0.157
ENSG00000047249 E031 109.7089184 0.0003038474 2.550036e-02 6.291469e-02 8 53833010 53833060 51 - 2.082 2.011 -0.238
ENSG00000047249 E032 73.1747532 0.0068046192 4.226010e-02 9.520132e-02 8 53833061 53833086 26 - 1.928 1.814 -0.382
ENSG00000047249 E033 0.0000000       8 53833087 53833189 103 -      
ENSG00000047249 E034 0.0000000       8 53839625 53839961 337 -      
ENSG00000047249 E035 119.6407614 0.0049442125 2.529483e-03 8.851182e-03 8 53841578 53841624 47 - 2.149 2.009 -0.470
ENSG00000047249 E036 150.2612003 0.0049169279 3.527021e-04 1.590837e-03 8 53841625 53841725 101 - 2.254 2.097 -0.524
ENSG00000047249 E037 1.5521107 0.0087363863 8.865802e-02 1.730743e-01 8 53842504 53842870 367 - 0.531 0.232 -1.758
ENSG00000047249 E038 8.7087557 0.0020831766 1.335578e-02 3.674858e-02 8 53842871 53842955 85 - 1.113 0.846 -0.994
ENSG00000047249 E039 1.9208195 0.0074567897 2.017030e-02 5.184034e-02 8 53842956 53843033 78 - 0.633 0.232 -2.219
ENSG00000047249 E040 192.3902124 0.0014558660 1.615478e-08 1.915928e-07 8 53843034 53843558 525 - 2.365 2.193 -0.576