ENSG00000047230

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359276 ENSG00000047230 HEK293_OSMI2_2hA HEK293_TMG_2hB CTPS2 protein_coding protein_coding 12.3745 8.763174 17.33852 1.077177 0.2372953 0.9836417 5.170005 5.0273426 6.4404794 1.0635257 0.1720159 0.356743536 0.4384417 0.56146667 0.37136667 -0.19010000 0.01627328 0.0102525 FALSE TRUE
ENST00000380241 ENSG00000047230 HEK293_OSMI2_2hA HEK293_TMG_2hB CTPS2 protein_coding protein_coding 12.3745 8.763174 17.33852 1.077177 0.2372953 0.9836417 1.937352 0.4707419 2.9831026 0.1873801 0.1804916 2.638307209 0.1398000 0.05286667 0.17190000 0.11903333 0.01663680 0.0102525 FALSE TRUE
ENST00000483053 ENSG00000047230 HEK293_OSMI2_2hA HEK293_TMG_2hB CTPS2 protein_coding processed_transcript 12.3745 8.763174 17.33852 1.077177 0.2372953 0.9836417 1.005664 0.7430004 0.7480128 0.1189497 0.3405440 0.009571486 0.1025958 0.08746667 0.04336667 -0.04410000 0.43549133 0.0102525   FALSE
MSTRG.33942.8 ENSG00000047230 HEK293_OSMI2_2hA HEK293_TMG_2hB CTPS2 protein_coding   12.3745 8.763174 17.33852 1.077177 0.2372953 0.9836417 2.751204 1.9470414 4.5149184 0.2456471 0.3077293 1.209217493 0.2036000 0.23243333 0.26096667 0.02853333 0.81755204 0.0102525 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047230 E001 1.5737920 0.0642050550 4.945702e-01 6.314945e-01 X 16587999 16588002 4 - 0.357 0.487 0.698
ENSG00000047230 E002 78.1351847 0.0039607539 2.462386e-09 3.394889e-08 X 16588003 16588305 303 - 1.749 2.052 1.019
ENSG00000047230 E003 262.8117142 0.0015573473 2.971837e-03 1.017928e-02 X 16588306 16589439 1134 - 2.385 2.472 0.290
ENSG00000047230 E004 55.6865488 0.0004462094 4.069663e-01 5.506038e-01 X 16589440 16589541 102 - 1.772 1.740 -0.109
ENSG00000047230 E005 27.9786398 0.0007319013 2.190988e-02 5.549147e-02 X 16589542 16589548 7 - 1.524 1.377 -0.506
ENSG00000047230 E006 117.5469092 0.0024708851 5.427954e-01 6.735064e-01 X 16589549 16589775 227 - 2.062 2.092 0.100
ENSG00000047230 E007 105.6463586 0.0003313141 4.833477e-02 1.062184e-01 X 16590752 16590862 111 - 1.999 2.073 0.250
ENSG00000047230 E008 4.7658480 0.0295812698 1.009285e-01 1.918834e-01 X 16590863 16591045 183 - 0.635 0.883 0.999
ENSG00000047230 E009 120.3894509 0.0029008975 2.327004e-01 3.656513e-01 X 16609541 16609685 145 - 2.062 2.119 0.191
ENSG00000047230 E010 92.8384961 0.0027897812 1.800598e-02 4.714568e-02 X 16617150 16617246 97 - 1.925 2.038 0.378
ENSG00000047230 E011 68.8351613 0.0077941857 4.689778e-01 6.083039e-01 X 16620277 16620332 56 - 1.822 1.880 0.197
ENSG00000047230 E012 0.8136755 0.0145884041 9.422064e-01 9.677301e-01 X 16638487 16638961 475 - 0.247 0.263 0.118
ENSG00000047230 E013 97.2578166 0.0003019502 1.561692e-01 2.700345e-01 X 16639147 16639243 97 - 1.970 2.027 0.191
ENSG00000047230 E014 78.3404035 0.0010018764 3.091584e-01 4.514285e-01 X 16667514 16667557 44 - 1.881 1.928 0.159
ENSG00000047230 E015 77.2234929 0.0004318537 5.763644e-01 7.018106e-01 X 16667662 16667724 63 - 1.901 1.884 -0.057
ENSG00000047230 E016 102.4449824 0.0003331030 1.507751e-01 2.627337e-01 X 16670580 16670674 95 - 2.033 1.988 -0.151
ENSG00000047230 E017 97.3281371 0.0003536976 4.898489e-01 6.272247e-01 X 16678362 16678450 89 - 2.000 1.981 -0.065
ENSG00000047230 E018 103.1911231 0.0019814236 2.902062e-01 4.309988e-01 X 16683094 16683226 133 - 1.997 2.040 0.141
ENSG00000047230 E019 97.9290891 0.0004757117 3.574577e-01 5.018734e-01 X 16689450 16689601 152 - 2.005 1.977 -0.096
ENSG00000047230 E020 80.8062883 0.0003443714 3.204546e-01 4.635845e-01 X 16691540 16691620 81 - 1.926 1.893 -0.112
ENSG00000047230 E021 81.4338551 0.0003467205 3.096376e-02 7.384549e-02 X 16693141 16693224 84 - 1.951 1.872 -0.265
ENSG00000047230 E022 91.8259460 0.0119311338 2.964778e-01 4.376954e-01 X 16693371 16693487 117 - 1.995 1.926 -0.232
ENSG00000047230 E023 75.7028888 0.0003554355 9.615631e-03 2.781828e-02 X 16698236 16698336 101 - 1.926 1.826 -0.338
ENSG00000047230 E024 93.8551249 0.0012813757 2.665006e-04 1.243173e-03 X 16698923 16699093 171 - 2.031 1.886 -0.487
ENSG00000047230 E025 83.3027487 0.0040069033 1.158650e-05 7.586848e-05 X 16702737 16702941 205 - 2.005 1.785 -0.743
ENSG00000047230 E026 0.9201396 0.0167857066 2.565466e-01 3.935144e-01 X 16707409 16707435 27 - 0.357 0.151 -1.619
ENSG00000047230 E027 1.0373134 0.0119999550 1.930316e-02 4.999166e-02 X 16708419 16708518 100 - 0.445 0.001 -10.428
ENSG00000047230 E028 2.5580998 0.0071107217 5.586647e-01 6.868764e-01 X 16711513 16712334 822 - 0.580 0.488 -0.434
ENSG00000047230 E029 19.1386902 0.0066337165 4.436920e-02 9.905504e-02 X 16712335 16712412 78 - 1.370 1.191 -0.627
ENSG00000047230 E030 12.2712086 0.0033656672 7.934976e-02 1.584912e-01 X 16712413 16712420 8 - 1.191 1.023 -0.608
ENSG00000047230 E031 22.0379979 0.0070075528 1.736357e-01 2.929135e-01 X 16712421 16712557 137 - 1.406 1.293 -0.393
ENSG00000047230 E032 21.3458868 0.0008917782 2.058092e-01 3.334212e-01 X 16712558 16712721 164 - 1.384 1.294 -0.313
ENSG00000047230 E033 13.0741543 0.0013186610 3.954652e-03 1.301593e-02 X 16712722 16712827 106 - 1.245 0.969 -0.998
ENSG00000047230 E034 8.3841439 0.0022856290 2.776793e-02 6.755470e-02 X 16712828 16712936 109 - 1.059 0.806 -0.954