ENSG00000047188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000161863 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding protein_coding 11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 7.3684152 1.78284779 13.9243087 0.36500136 0.88258772 2.958317 0.55374583 0.5307000 0.71583333 0.18513333 4.649574e-01 1.329024e-10 FALSE TRUE
ENST00000507567 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding retained_intron 11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 0.9581052 0.00000000 1.0897445 0.00000000 0.20087406 6.781025 0.07127917 0.0000000 0.05613333 0.05613333 1.285403e-04 1.329024e-10 FALSE FALSE
ENST00000512600 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding retained_intron 11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 0.5530591 0.22029326 0.7138917 0.04411491 0.06292766 1.652302 0.06020000 0.0635000 0.03666667 -0.02683333 2.592783e-01 1.329024e-10 FALSE TRUE
MSTRG.26764.1 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding   11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 0.5097234 0.00000000 1.0539316 0.00000000 0.53134958 6.733262 0.03825417 0.0000000 0.05406667 0.05406667 4.364170e-01 1.329024e-10 TRUE TRUE
MSTRG.26764.4 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding   11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 0.3441002 0.03106085 1.4539726 0.03106085 1.04502362 5.155981 0.02175000 0.0098000 0.07480000 0.06500000 6.983242e-01 1.329024e-10 TRUE TRUE
MSTRG.26764.9 ENSG00000047188 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC2 protein_coding   11.65778 3.417313 19.44901 0.1981543 0.1089648 2.505288 0.6244403 1.18458648 0.0000000 0.40373403 0.00000000 -6.900367 0.13932500 0.3373667 0.00000000 -0.33736667 1.329024e-10 1.329024e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047188 E001 4.9045268 0.0046746368 1.726855e-03 6.367462e-03 5 113513694 113513708 15 + 0.725 0.000 -13.543
ENSG00000047188 E002 19.7435768 0.0020401390 7.893948e-03 2.351243e-02 5 113513709 113513732 24 + 1.225 0.960 -0.962
ENSG00000047188 E003 20.6420602 0.0053825278 5.873273e-03 1.827951e-02 5 113513733 113513733 1 + 1.245 0.960 -1.032
ENSG00000047188 E004 23.1886229 0.0034784579 2.461539e-03 8.648465e-03 5 113513734 113513750 17 + 1.294 0.997 -1.065
ENSG00000047188 E005 33.3831757 0.0006436587 5.082367e-03 1.615448e-02 5 113513751 113513817 67 + 1.435 1.236 -0.694
ENSG00000047188 E006 49.2838893 0.0004368220 2.175380e-05 1.337008e-04 5 113513818 113513963 146 + 1.607 1.328 -0.959
ENSG00000047188 E007 46.5088612 0.0004814128 1.361724e-06 1.098606e-05 5 113513964 113514082 119 + 1.588 1.236 -1.218
ENSG00000047188 E008 0.1451727 0.0425297110 1.000000e+00   5 113514146 113514275 130 + 0.053 0.000 -8.489
ENSG00000047188 E009 47.1406745 0.0007370150 9.371671e-05 4.924377e-04 5 113515272 113515362 91 + 1.585 1.328 -0.885
ENSG00000047188 E010 81.7487313 0.0005946341 1.906236e-06 1.489813e-05 5 113524981 113525177 197 + 1.817 1.583 -0.792
ENSG00000047188 E011 81.8396737 0.0035216270 7.958407e-05 4.259029e-04 5 113526586 113526785 200 + 1.815 1.611 -0.693
ENSG00000047188 E012 75.4222342 0.0007716281 1.535453e-07 1.504302e-06 5 113532879 113533045 167 + 1.789 1.503 -0.975
ENSG00000047188 E013 57.4023267 0.0003880765 8.855568e-08 9.080217e-07 5 113534305 113534407 103 + 1.679 1.328 -1.205
ENSG00000047188 E014 55.3324694 0.0004530289 6.045283e-06 4.224651e-05 5 113535642 113535798 157 + 1.657 1.375 -0.967
ENSG00000047188 E015 0.0000000       5 113535799 113535802 4 +      
ENSG00000047188 E016 42.9975980 0.0060578759 4.102811e-04 1.813667e-03 5 113539074 113539181 108 + 1.548 1.276 -0.943
ENSG00000047188 E017 60.9028224 0.0004318930 1.801675e-01 3.013800e-01 5 113540968 113541116 149 + 1.664 1.635 -0.098
ENSG00000047188 E018 70.3790122 0.0004548074 3.000405e-02 7.196801e-02 5 113542368 113542503 136 + 1.733 1.659 -0.252
ENSG00000047188 E019 71.1810979 0.0003605939 1.028654e-04 5.352987e-04 5 113548541 113548667 127 + 1.753 1.565 -0.640
ENSG00000047188 E020 57.9086379 0.0013742383 2.484523e-05 1.508124e-04 5 113548955 113549020 66 + 1.673 1.417 -0.874
ENSG00000047188 E021 75.8663439 0.0003744599 1.007402e-04 5.252923e-04 5 113553181 113553359 179 + 1.781 1.601 -0.610
ENSG00000047188 E022 64.8074113 0.0004890546 1.978051e-04 9.544003e-04 5 113553590 113553686 97 + 1.714 1.524 -0.647
ENSG00000047188 E023 62.8072310 0.0004563173 4.610360e-04 2.010540e-03 5 113553767 113553854 88 + 1.701 1.524 -0.601
ENSG00000047188 E024 52.6829098 0.0004270942 3.135969e-03 1.066453e-02 5 113553942 113554022 81 + 1.623 1.468 -0.530
ENSG00000047188 E025 51.5165042 0.0004185006 5.334740e-03 1.684193e-02 5 113556052 113556134 83 + 1.612 1.468 -0.493
ENSG00000047188 E026 0.7469680 0.0168638195 4.497487e-01 5.909468e-01 5 113556135 113556360 226 + 0.218 0.000 -10.812
ENSG00000047188 E027 30.0936463 0.0014923335 1.617305e-02 4.310545e-02 5 113561080 113561084 5 + 1.389 1.215 -0.608
ENSG00000047188 E028 67.2416085 0.0010724707 1.390687e-02 3.801591e-02 5 113561085 113561185 101 + 1.719 1.619 -0.338
ENSG00000047188 E029 0.1451727 0.0425297110 1.000000e+00   5 113561186 113561196 11 + 0.053 0.000 -8.489
ENSG00000047188 E030 74.4451484 0.0003269836 7.007457e-03 2.124339e-02 5 113563373 113563492 120 + 1.762 1.659 -0.348
ENSG00000047188 E031 74.0960449 0.0003945502 1.996617e-02 5.141335e-02 5 113563859 113563940 82 + 1.755 1.674 -0.273
ENSG00000047188 E032 70.6291398 0.0003561379 7.083487e-02 1.447325e-01 5 113563941 113564041 101 + 1.732 1.682 -0.172
ENSG00000047188 E033 65.1026974 0.0075207627 5.332504e-02 1.150692e-01 5 113564042 113564131 90 + 1.702 1.613 -0.304
ENSG00000047188 E034 1.2512699 0.0102974627 4.891619e-01 6.266457e-01 5 113565719 113565892 174 + 0.251 0.419 1.051
ENSG00000047188 E035 78.3736121 0.0056166153 8.937925e-05 4.720687e-04 5 113565893 113566019 127 + 1.799 1.574 -0.763
ENSG00000047188 E036 104.3234690 0.0024884147 6.287163e-04 2.638352e-03 5 113567092 113567297 206 + 1.913 1.779 -0.452
ENSG00000047188 E037 98.6211440 0.0004362215 2.576605e-01 3.948219e-01 5 113567654 113567849 196 + 1.869 1.869 0.000
ENSG00000047188 E038 85.4476375 0.0007203463 5.973798e-01 7.191552e-01 5 113579586 113579695 110 + 1.802 1.829 0.092
ENSG00000047188 E039 0.0000000       5 113581266 113581416 151 +      
ENSG00000047188 E040 130.5640815 0.0012022015 1.865987e-01 3.094680e-01 5 113581417 113581709 293 + 1.967 2.078 0.372
ENSG00000047188 E041 6.1966079 0.0272251441 1.455978e-01 2.556734e-01 5 113581710 113584301 2592 + 0.776 0.536 -1.028
ENSG00000047188 E042 114.1658642 0.0002884927 4.408976e-01 5.825427e-01 5 113584302 113584479 178 + 1.912 2.000 0.295
ENSG00000047188 E043 104.1718422 0.0003208953 1.094797e-01 2.048031e-01 5 113591041 113591157 117 + 1.868 1.993 0.421
ENSG00000047188 E044 92.3312214 0.0005371711 1.441086e-02 3.915797e-02 5 113591158 113591244 87 + 1.807 1.975 0.565
ENSG00000047188 E045 129.4512323 0.0002390808 1.882074e-07 1.812399e-06 5 113591996 113592178 183 + 1.932 2.182 0.835
ENSG00000047188 E046 36.2156647 0.0014161868 5.160845e-01 6.506592e-01 5 113592179 113593302 1124 + 1.441 1.444 0.008
ENSG00000047188 E047 53.9170440 0.0004362477 3.528529e-04 1.591328e-03 5 113593303 113593317 15 + 1.555 1.814 0.879
ENSG00000047188 E048 85.0374785 0.0003616782 3.266420e-10 5.282232e-09 5 113593318 113593390 73 + 1.727 2.062 1.128
ENSG00000047188 E049 29.5135715 0.0006947867 2.102578e-01 3.388402e-01 5 113593391 113593481 91 + 1.327 1.480 0.529
ENSG00000047188 E050 84.0239205 0.0003077266 3.736132e-10 5.987641e-09 5 113593482 113593550 69 + 1.721 2.056 1.129
ENSG00000047188 E051 113.9067617 0.0005183921 8.495985e-19 4.736724e-17 5 113593551 113593810 260 + 1.831 2.226 1.326
ENSG00000047188 E052 412.7056117 0.0222394882 2.286293e-07 2.167825e-06 5 113593811 113595285 1475 + 2.388 2.794 1.353