ENSG00000047056

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358220 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding protein_coding 6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 1.7713822 1.1804472 2.1518169 0.12028076 0.7823077 0.8607406 0.26441667 0.23660000 0.29953333 0.06293333 9.061637e-01 4.639457e-19 FALSE TRUE
ENST00000436154 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding protein_coding 6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 0.1097121 0.0000000 0.4333228 0.00000000 0.3356696 5.4702855 0.01514167 0.00000000 0.05366667 0.05366667 2.960028e-01 4.639457e-19 FALSE FALSE
ENST00000482165 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding processed_transcript 6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 0.9426953 2.0095404 0.0000000 0.37690927 0.0000000 -7.6578832 0.16906667 0.39696667 0.00000000 -0.39696667 4.639457e-19 4.639457e-19   FALSE
ENST00000650072 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding protein_coding 6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 0.3938776 0.1894310 0.3959173 0.10247291 0.2175417 1.0252961 0.05987500 0.04026667 0.05110000 0.01083333 9.833717e-01 4.639457e-19 FALSE TRUE
MSTRG.3478.1 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding   6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 0.7035063 0.3827681 0.7794974 0.04709736 0.3090919 1.0072568 0.10762083 0.07743333 0.10893333 0.03150000 8.445375e-01 4.639457e-19 FALSE TRUE
MSTRG.3478.4 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding   6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 0.8717521 0.7126115 1.4141474 0.13049376 0.4104912 0.9788064 0.13560417 0.14336667 0.18960000 0.04623333 8.110567e-01 4.639457e-19 FALSE TRUE
MSTRG.3478.9 ENSG00000047056 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR37 protein_coding   6.521234 5.012353 7.395309 0.2824006 0.4713171 0.5601964 1.0551969 0.3061745 1.3211360 0.15735916 0.3728770 2.0738650 0.15201250 0.05846667 0.17460000 0.11613333 3.073271e-01 4.639457e-19   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000047056 E001 1.1070397 0.0142776522 1.097982e-01 2.052650e-01 10 1049479 1049494 16 + 0.176 0.493 2.078
ENSG00000047056 E002 1.4402595 0.0099284607 1.258979e-01 2.284248e-01 10 1049495 1049498 4 + 0.243 0.549 1.757
ENSG00000047056 E003 4.3596891 0.0037341320 3.669367e-02 8.489664e-02 10 1049499 1049537 39 + 0.544 0.891 1.437
ENSG00000047056 E004 12.2650256 0.0124970644 9.539581e-04 3.801445e-03 10 1049538 1049641 104 + 0.890 1.304 1.502
ENSG00000047056 E005 5.7132624 0.0027941047 1.639311e-01 2.802710e-01 10 1050298 1055615 5318 + 0.875 0.752 -0.483
ENSG00000047056 E006 2.6037159 0.0080721603 8.158431e-01 8.834368e-01 10 1056348 1056384 37 + 0.512 0.598 0.397
ENSG00000047056 E007 2.5056735 0.0058858422 4.318828e-01 5.743814e-01 10 1056385 1056403 19 + 0.574 0.494 -0.379
ENSG00000047056 E008 3.4936796 0.0141434077 4.064011e-01 5.500491e-01 10 1056404 1056466 63 + 0.677 0.598 -0.339
ENSG00000047056 E009 4.7460057 0.0042346986 9.219352e-01 9.547485e-01 10 1056467 1056564 98 + 0.741 0.784 0.174
ENSG00000047056 E010 1.1866507 0.1317887219 3.972052e-01 5.409807e-01 10 1056565 1056824 260 + 0.398 0.264 -0.848
ENSG00000047056 E011 4.8705533 0.1227377855 9.273143e-01 9.582370e-01 10 1056825 1056846 22 + 0.760 0.779 0.077
ENSG00000047056 E012 7.7396104 0.0031956486 3.831470e-01 5.273232e-01 10 1056847 1056879 33 + 0.954 0.914 -0.154
ENSG00000047056 E013 12.6563381 0.0017041312 2.652469e-02 6.500087e-02 10 1056880 1056968 89 + 1.184 1.031 -0.550
ENSG00000047056 E014 13.0487184 0.0020784376 3.801965e-02 8.738924e-02 10 1072116 1072125 10 + 1.198 1.064 -0.481
ENSG00000047056 E015 31.7295668 0.0015621656 2.517498e-03 8.815920e-03 10 1072126 1072293 168 + 1.563 1.435 -0.438
ENSG00000047056 E016 0.6611159 0.0189227783 5.171655e-01 6.516188e-01 10 1074383 1074508 126 + 0.243 0.153 -0.824
ENSG00000047056 E017 20.8733766 0.0008950305 2.735455e-03 9.479817e-03 10 1077907 1078003 97 + 1.398 1.233 -0.579
ENSG00000047056 E018 35.4508625 0.0030864399 1.017882e-05 6.752863e-05 10 1080011 1080106 96 + 1.634 1.408 -0.775
ENSG00000047056 E019 34.4597034 0.0157516500 4.521248e-03 1.460296e-02 10 1080412 1080476 65 + 1.608 1.425 -0.626
ENSG00000047056 E020 45.6843771 0.0144565549 1.417181e-03 5.364124e-03 10 1084403 1084538 136 + 1.730 1.544 -0.634
ENSG00000047056 E021 27.5259887 0.0008670322 1.053563e-02 3.005623e-02 10 1086286 1086357 72 + 1.492 1.385 -0.367
ENSG00000047056 E022 15.7196223 0.0011700289 6.948329e-02 1.425012e-01 10 1093452 1093496 45 + 1.256 1.163 -0.329
ENSG00000047056 E023 19.3740896 0.0124512481 1.004575e-01 1.911624e-01 10 1096170 1096246 77 + 1.338 1.245 -0.325
ENSG00000047056 E024 4.2845280 0.0039775962 1.096336e-01 2.050261e-01 10 1096247 1096626 380 + 0.778 0.598 -0.755
ENSG00000047056 E025 2.1035655 0.0070509604 3.551990e-01 4.995686e-01 10 1102458 1102577 120 + 0.398 0.598 0.980
ENSG00000047056 E026 2.6538492 0.2158452859 1.583725e-01 2.729548e-01 10 1102856 1102978 123 + 0.352 0.748 1.882
ENSG00000047056 E027 2.6810075 0.1630522338 7.814230e-01 8.595816e-01 10 1103535 1103598 64 + 0.511 0.605 0.434
ENSG00000047056 E028 8.4654354 0.0321250749 8.661463e-02 1.699839e-01 10 1103599 1103601 3 + 1.031 0.845 -0.702
ENSG00000047056 E029 36.8855173 0.0006288227 3.562872e-03 1.190622e-02 10 1103602 1103836 235 + 1.613 1.510 -0.354
ENSG00000047056 E030 37.4721834 0.0005571828 1.811097e-03 6.634314e-03 10 1105126 1105267 142 + 1.624 1.510 -0.389
ENSG00000047056 E031 0.6966155 0.0168708330 1.706091e-01 2.889543e-01 10 1123807 1124102 296 + 0.097 0.356 2.345
ENSG00000047056 E032 42.2122836 0.0005838136 8.994702e-03 2.626600e-02 10 1124218 1124352 135 + 1.658 1.583 -0.257
ENSG00000047056 E033 38.8370931 0.0006238462 7.713484e-01 8.523909e-01 10 1124910 1125024 115 + 1.577 1.628 0.173
ENSG00000047056 E034 510.2550482 0.0038614424 5.314862e-14 1.571293e-12 10 1129213 1132384 3172 + 2.606 2.812 0.683