ENSG00000046889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288368 ENSG00000046889 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX2 protein_coding protein_coding 0.5582796 0.1704607 1.02406 0.06143318 0.1389265 2.518563 0.29309077 0.10275944 0.51767661 0.008279718 0.005522442 2.226406 0.6535250 0.7688667 0.52883333 -0.24003333 0.6385274 0.03443 FALSE TRUE
ENST00000517617 ENSG00000046889 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX2 protein_coding processed_transcript 0.5582796 0.1704607 1.02406 0.06143318 0.1389265 2.518563 0.12239993 0.00000000 0.29209566 0.000000000 0.032571772 4.916934 0.1282458 0.0000000 0.28740000 0.28740000 0.0344300 0.03443 FALSE TRUE
ENST00000522247 ENSG00000046889 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX2 protein_coding processed_transcript 0.5582796 0.1704607 1.02406 0.06143318 0.1389265 2.518563 0.11750110 0.06770131 0.18781373 0.067701308 0.108811704 1.348132 0.1430875 0.2311333 0.15973333 -0.07140000 0.9712155 0.03443 FALSE FALSE
ENST00000529398 ENSG00000046889 HEK293_OSMI2_2hA HEK293_TMG_2hB PREX2 protein_coding processed_transcript 0.5582796 0.1704607 1.02406 0.06143318 0.1389265 2.518563 0.01447293 0.00000000 0.02647379 0.000000000 0.026473792 1.866860 0.0524750 0.0000000 0.02403333 0.02403333 1.0000000 0.03443 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000046889 E001 1.5971752 0.0098164261 0.241797264 0.37631249 8 67952046 67952367 322 + 0.311 0.495 1.020
ENSG00000046889 E002 1.4790604 0.0091426534 0.142166850 0.25098859 8 67952368 67952488 121 + 0.397 0.000 -13.290
ENSG00000046889 E003 1.9229976 0.0073974570 0.076009849 0.15312949 8 67952489 67952535 47 + 0.469 0.000 -13.514
ENSG00000046889 E004 1.9272640 0.0073706665 0.076013551 0.15313369 8 68017846 68017917 72 + 0.469 0.000 -13.514
ENSG00000046889 E005 3.1137890 0.0221281800 0.018161856 0.04747967 8 68019549 68019671 123 + 0.617 0.000 -13.892
ENSG00000046889 E006 3.2526189 0.0057145570 0.013267508 0.03654231 8 68022036 68022140 105 + 0.633 0.000 -13.934
ENSG00000046889 E007 2.8128345 0.0906822712 0.040320086 0.09162082 8 68027222 68027323 102 + 0.585 0.000 -13.786
ENSG00000046889 E008 3.9264454 0.0048044923 0.582166402 0.70658200 8 68030497 68030658 162 + 0.648 0.495 -0.697
ENSG00000046889 E009 3.4459766 0.0046313458 0.345845407 0.48998904 8 68038159 68038292 134 + 0.617 0.383 -1.151
ENSG00000046889 E010 4.7318051 0.0036656504 0.112896394 0.20977305 8 68044487 68044590 104 + 0.739 0.383 -1.665
ENSG00000046889 E011 5.0465910 0.0054312090 0.017481228 0.04600314 8 68053097 68053246 150 + 0.774 0.232 -2.803
ENSG00000046889 E012 3.0473063 0.0108243745 0.152383478 0.26492085 8 68055830 68055974 145 + 0.585 0.233 -2.005
ENSG00000046889 E013 3.4635688 0.0048158828 0.094127456 0.18158472 8 68060679 68060779 101 + 0.633 0.233 -2.216
ENSG00000046889 E014 3.8566043 0.0043514695 0.006225431 0.01920695 8 68069033 68069136 104 + 0.689 0.000 -14.062
ENSG00000046889 E015 2.8172146 0.0056070593 0.023344309 0.05846709 8 68069835 68069884 50 + 0.585 0.000 -13.821
ENSG00000046889 E016 2.8956772 0.0055815743 0.171944775 0.29073452 8 68072495 68072570 76 + 0.567 0.233 -1.927
ENSG00000046889 E017 2.4735099 0.0061791743 0.754558004 0.84016333 8 68077397 68077469 73 + 0.491 0.383 -0.564
ENSG00000046889 E018 3.5754571 0.0074017405 0.081918966 0.16257047 8 68080443 68080585 143 + 0.647 0.232 -2.281
ENSG00000046889 E019 3.9066006 0.0408764655 0.277448149 0.41701084 8 68080746 68080838 93 + 0.662 0.383 -1.340
ENSG00000046889 E020 4.5194549 0.0078735045 0.834152548 0.89613409 8 68083240 68083388 149 + 0.676 0.657 -0.080
ENSG00000046889 E021 1.6919979 0.0085248651 0.311261820 0.45371518 8 68087724 68087809 86 + 0.342 0.495 0.827
ENSG00000046889 E022 2.2821399 0.0076022474 0.832189263 0.89483077 8 68090579 68090715 137 + 0.469 0.383 -0.458
ENSG00000046889 E023 2.8484477 0.0053295483 0.546109480 0.67634278 8 68093605 68093722 118 + 0.549 0.383 -0.846
ENSG00000046889 E024 3.7416325 0.0044513637 0.637798471 0.75160255 8 68097017 68097201 185 + 0.633 0.495 -0.633
ENSG00000046889 E025 3.6107291 0.0046896669 0.697778939 0.79782322 8 68099682 68099843 162 + 0.617 0.495 -0.565
ENSG00000046889 E026 0.1515154 0.0436868209 1.000000000   8 68105138 68106007 870 + 0.061 0.000 -10.803
ENSG00000046889 E027 3.3527628 0.0051176390 0.711764662 0.80866071 8 68108109 68108331 223 + 0.567 0.583 0.072
ENSG00000046889 E028 5.1787726 0.0035350821 0.705597864 0.80392479 8 68109416 68109623 208 + 0.715 0.720 0.019
ENSG00000046889 E029 0.0000000       8 68110932 68111089 158 +      
ENSG00000046889 E030 5.8240826 0.0030994710 0.927876378 0.95860066 8 68115753 68115932 180 + 0.762 0.720 -0.172
ENSG00000046889 E031 3.3790015 0.0925921088 0.931685324 0.96096360 8 68118550 68118644 95 + 0.584 0.497 -0.405
ENSG00000046889 E032 2.4724778 0.0089433296 0.704913581 0.80336741 8 68119432 68119514 83 + 0.469 0.495 0.127
ENSG00000046889 E033 2.6991224 0.0057122359 0.609289041 0.72881032 8 68120196 68120286 91 + 0.531 0.383 -0.758
ENSG00000046889 E034 4.8143317 0.0036227517 0.956755871 0.97688165 8 68120921 68121049 129 + 0.702 0.657 -0.192
ENSG00000046889 E035 3.1365118 0.0049968774 0.029784737 0.07154069 8 68127378 68127419 42 + 0.469 0.775 1.349
ENSG00000046889 E036 5.6390397 0.0099194198 0.133652928 0.23922137 8 68134059 68134276 218 + 0.702 0.868 0.659
ENSG00000046889 E037 4.0827618 0.0457592980 0.050871605 0.11072719 8 68138415 68138517 103 + 0.549 0.828 1.172
ENSG00000046889 E038 4.1537528 0.0045752482 0.339569651 0.48350220 8 68146209 68146352 144 + 0.617 0.720 0.435
ENSG00000046889 E039 2.2444743 0.0075304287 0.260372132 0.39788597 8 68157322 68157374 53 + 0.422 0.583 0.781
ENSG00000046889 E040 2.0993016 0.0073907409 0.208895496 0.33720135 8 68157375 68157406 32 + 0.397 0.583 0.919
ENSG00000046889 E041 1.8800319 0.0076576902 0.121588892 0.22219849 8 68157407 68157436 30 + 0.342 0.583 1.242
ENSG00000046889 E042 2.5421921 0.0061513255 0.030304245 0.07256586 8 68191722 68191788 67 + 0.397 0.720 1.505
ENSG00000046889 E043 3.1386888 0.0054117237 0.029729185 0.07142628 8 68192335 68192525 191 + 0.469 0.775 1.349
ENSG00000046889 E044 0.5901540 0.0203376177 0.595191283 0.71732401 8 68192526 68192630 105 + 0.161 0.232 0.656
ENSG00000046889 E045 0.5954526 0.0185743725 0.638489146 0.75211628 8 68217616 68217718 103 + 0.204 0.000 -12.415
ENSG00000046889 E046 0.0000000       8 68220176 68220350 175 +      
ENSG00000046889 E047 0.5922303 0.0181968269 0.595412293 0.71751940 8 68224559 68224626 68 + 0.161 0.232 0.656
ENSG00000046889 E048 35.1232629 0.0008021709 0.004693863 0.01507874 8 68231333 68237032 5700 + 1.441 1.552 0.381