ENSG00000044459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380641 ENSG00000044459 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTLN protein_coding protein_coding 2.513864 0.9631287 3.719068 0.0868401 0.2170238 1.938112 0.5476955 0.2148483 0.8539838 0.03424599 0.06868386 1.942052 0.2248917 0.2269333 0.2292667 0.002333333 0.98922696 0.02121115 FALSE TRUE
ENST00000380647 ENSG00000044459 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTLN protein_coding protein_coding 2.513864 0.9631287 3.719068 0.0868401 0.2170238 1.938112 0.6225595 0.0000000 0.9853488 0.00000000 0.43224004 6.637130 0.2057875 0.0000000 0.2527333 0.252733333 0.02121115 0.02121115 FALSE TRUE
ENST00000484374 ENSG00000044459 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTLN protein_coding processed_transcript 2.513864 0.9631287 3.719068 0.0868401 0.2170238 1.938112 0.6879635 0.3974836 1.0607259 0.02373269 0.13613935 1.393775 0.2869833 0.4153333 0.2832667 -0.132066667 0.26487283 0.02121115 FALSE TRUE
MSTRG.32429.2 ENSG00000044459 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTLN protein_coding   2.513864 0.9631287 3.719068 0.0868401 0.2170238 1.938112 0.6107921 0.3507968 0.8190093 0.07284597 0.40534541 1.200202 0.2646958 0.3577000 0.2347000 -0.123000000 0.64146556 0.02121115 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000044459 E001 1.874835 0.0082799240 6.281279e-01 0.743763468 9 17134982 17135039 58 + 0.385 0.478 0.492
ENSG00000044459 E002 22.815225 0.0009087627 6.706378e-02 0.138482016 9 17135040 17135425 386 + 1.262 1.410 0.518
ENSG00000044459 E003 16.095825 0.0015221639 4.096747e-01 0.553284277 9 17143288 17143376 89 + 1.175 1.092 -0.296
ENSG00000044459 E004 31.937557 0.0010319794 3.096886e-04 0.001418951 9 17166818 17168556 1739 + 1.374 1.614 0.823
ENSG00000044459 E005 13.377210 0.0108705008 3.371682e-01 0.481030064 9 17226203 17226287 85 + 1.099 0.988 -0.407
ENSG00000044459 E006 17.290269 0.0010940744 4.824433e-02 0.106066414 9 17235658 17235792 135 + 1.222 1.015 -0.746
ENSG00000044459 E007 17.070069 0.0012565190 3.086791e-02 0.073660492 9 17236409 17236588 180 + 1.218 0.986 -0.837
ENSG00000044459 E008 11.033525 0.0082784297 3.250134e-02 0.076808556 9 17273733 17273866 134 + 1.053 0.755 -1.135
ENSG00000044459 E009 10.659314 0.0065480706 6.965098e-01 0.796838655 9 17298190 17298352 163 + 1.001 0.956 -0.170
ENSG00000044459 E010 47.376726 0.0159264774 6.959167e-02 0.142675538 9 17298353 17302051 3699 + 1.573 1.716 0.485
ENSG00000044459 E011 7.914497 0.0021881177 2.469444e-01 0.382350543 9 17309058 17309252 195 + 0.837 0.986 0.568
ENSG00000044459 E012 8.179851 0.0022041157 7.344759e-01 0.825414510 9 17330632 17330808 177 + 0.875 0.922 0.179
ENSG00000044459 E013 9.379180 0.0022505758 8.956046e-02 0.174451311 9 17332605 17332730 126 + 0.988 0.754 -0.898
ENSG00000044459 E014 9.656412 0.0257715180 3.760498e-01 0.520421275 9 17340827 17340948 122 + 0.981 0.846 -0.511
ENSG00000044459 E015 8.306618 0.0194218427 4.495812e-01 0.590781702 9 17342325 17342444 120 + 0.919 0.803 -0.447
ENSG00000044459 E016 8.067152 0.0021974055 1.627367e-02 0.043330346 9 17366617 17366717 101 + 0.943 0.565 -1.538
ENSG00000044459 E017 7.409910 0.0046159042 8.917864e-03 0.026075978 9 17388162 17388253 92 + 0.918 0.478 -1.861
ENSG00000044459 E018 18.367579 0.0037428687 2.420873e-03 0.008524669 9 17394534 17395069 536 + 1.266 0.922 -1.245
ENSG00000044459 E019 2.520754 0.1219999673 3.229909e-02 0.076429742 9 17409293 17409295 3 + 0.568 0.000 -11.265
ENSG00000044459 E020 8.475538 0.0091486869 3.513997e-01 0.495623251 9 17409296 17409473 178 + 0.935 0.802 -0.511
ENSG00000044459 E021 2.845339 0.0056755297 6.967028e-01 0.796987236 9 17415788 17415817 30 + 0.548 0.478 -0.340
ENSG00000044459 E022 3.521319 0.0044396520 1.610212e-01 0.276453570 9 17415818 17415881 64 + 0.636 0.369 -1.316
ENSG00000044459 E023 7.782550 0.0023180684 3.706258e-01 0.515033063 9 17415966 17416189 224 + 0.837 0.955 0.453
ENSG00000044459 E024 0.000000       9 17444197 17444246 50 +      
ENSG00000044459 E025 7.505919 0.0267441319 1.117871e-01 0.208181958 9 17457524 17457628 105 + 0.783 1.019 0.898
ENSG00000044459 E026 6.989980 0.0025038208 9.042427e-01 0.943060870 9 17457629 17457715 87 + 0.826 0.846 0.076
ENSG00000044459 E027 7.690966 0.0021455059 3.261656e-01 0.469615681 9 17462916 17463013 98 + 0.893 0.754 -0.542
ENSG00000044459 E028 7.492221 0.0023562118 5.945944e-01 0.716793655 9 17464497 17464623 127 + 0.875 0.803 -0.281
ENSG00000044459 E029 7.236460 0.0026855204 6.452910e-01 0.757412441 9 17465981 17466118 138 + 0.866 0.802 -0.247
ENSG00000044459 E030 9.471218 0.0292793234 3.686785e-01 0.513079781 9 17466706 17466891 186 + 0.980 0.844 -0.515
ENSG00000044459 E031 12.728564 0.0295811704 6.576900e-01 0.767003427 9 17484295 17484480 186 + 1.071 1.018 -0.196
ENSG00000044459 E032 8.725985 0.0019620362 6.878042e-01 0.790061456 9 17486989 17487066 78 + 0.902 0.955 0.202
ENSG00000044459 E033 34.716988 0.0007797434 5.102867e-05 0.000286955 9 17502551 17503923 1373 + 1.397 1.654 0.883