ENSG00000044446

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000379942	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding	protein_coding	19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	2.881584	4.315149	2.522785	0.92417127	0.4707348	-0.772025348	0.14997083	0.21050000	0.14933333	-0.06116667	0.6291374823	0.0005493942	FALSE
ENST00000464455	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding	processed_transcript	19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	1.689231	1.011334	2.141250	0.19486750	0.2650499	1.074720888	0.08852083	0.04960000	0.12703333	0.07743333	0.0045638485	0.0005493942	FALSE
ENST00000469485	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding	processed_transcript	19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	5.428609	6.125798	3.958168	0.80338995	0.1048491	-0.628777877	0.27581250	0.29850000	0.23563333	-0.06286667	0.4617167841	0.0005493942	FALSE
MSTRG.33970.16	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding		19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	1.920772	1.067148	2.277626	0.06013039	0.3088826	1.086635245	0.10388333	0.05206667	0.13590000	0.08383333	0.0005493942	0.0005493942	FALSE
MSTRG.33970.2	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding		19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	1.361836	1.697731	0.644612	0.52309796	0.3291224	-1.383368496	0.07011667	0.08283333	0.03893333	-0.04390000	0.6385274191	0.0005493942	FALSE
MSTRG.33970.4	ENSG00000044446	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PHKA2	protein_coding		19.09242	20.48515	16.80175	0.2779429	0.2753441	-0.2858125	2.790548	2.865104	2.869495	0.48656235	0.4053228	0.002201495	0.15679167	0.14043333	0.17016667	0.02973333	0.7216289871	0.0005493942	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 54
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000044446	E001	2.902505	0.0288555353	3.949663e-01	5.388068e-01	X	18892241	18892297	57	-	0.665	0.527	-0.613
ENSG00000044446	E002	87.093461	0.0003416330	2.077878e-04	9.972330e-04	X	18892298	18892971	674	-	1.823	1.979	0.523
ENSG00000044446	E003	19.882710	0.0009126687	2.874007e-01	4.278960e-01	X	18892972	18892972	1	-	1.243	1.333	0.316
ENSG00000044446	E004	292.205383	0.0004492863	2.792997e-22	2.292569e-20	X	18892973	18893447	475	-	2.282	2.519	0.793
ENSG00000044446	E005	123.312327	0.0063096100	4.766545e-06	3.409763e-05	X	18893448	18893521	74	-	1.904	2.148	0.817
ENSG00000044446	E006	145.762616	0.0025993149	2.066023e-06	1.602202e-05	X	18893522	18893655	134	-	2.015	2.209	0.650
ENSG00000044446	E007	3.295412	0.0053332242	6.063351e-01	7.265184e-01	X	18894082	18894203	122	-	0.665	0.591	-0.323
ENSG00000044446	E008	173.826487	0.0052967230	1.313426e-03	5.022095e-03	X	18894204	18894404	201	-	2.121	2.272	0.504
ENSG00000044446	E009	1.213603	0.0108647759	5.581101e-01	6.863982e-01	X	18894405	18895137	733	-	0.256	0.365	0.711
ENSG00000044446	E010	71.831964	0.0043167818	3.913045e-02	8.942924e-02	X	18895138	18895145	8	-	1.764	1.880	0.392
ENSG00000044446	E011	80.733315	0.0045556421	8.552839e-04	3.456434e-03	X	18895146	18895191	46	-	1.767	1.951	0.618
ENSG00000044446	E012	11.866020	0.0014510309	2.643220e-01	4.022800e-01	X	18895192	18896634	1443	-	1.155	1.052	-0.370
ENSG00000044446	E013	137.263570	0.0084723310	3.591377e-03	1.198541e-02	X	18897163	18897333	171	-	2.007	2.174	0.560
ENSG00000044446	E014	75.403999	0.0093265702	4.108090e-02	9.303465e-02	X	18897334	18897823	490	-	1.936	1.816	-0.405
ENSG00000044446	E015	39.860494	0.0190777029	9.439081e-01	9.688285e-01	X	18897824	18897973	150	-	1.589	1.588	-0.003
ENSG00000044446	E016	68.317419	0.0111891961	4.240984e-01	5.670916e-01	X	18897974	18898421	448	-	1.849	1.800	-0.164
ENSG00000044446	E017	29.579191	0.0149262846	1.371486e-01	2.441185e-01	X	18898971	18899148	178	-	1.546	1.418	-0.439
ENSG00000044446	E018	14.761446	0.0311102374	6.019860e-01	7.230312e-01	X	18899149	18899172	24	-	1.142	1.206	0.230
ENSG00000044446	E019	53.921746	0.0047722144	5.615980e-02	1.199863e-01	X	18899173	18899226	54	-	1.644	1.764	0.408
ENSG00000044446	E020	39.627248	0.0102730807	3.290337e-01	4.725244e-01	X	18900670	18900678	9	-	1.541	1.624	0.282
ENSG00000044446	E021	48.778484	0.0082513168	6.000342e-01	7.213273e-01	X	18900679	18900699	21	-	1.655	1.699	0.147
ENSG00000044446	E022	101.393247	0.0003257008	2.385239e-01	3.724265e-01	X	18901485	18901603	119	-	1.963	2.012	0.163
ENSG00000044446	E023	1.471569	0.0448437186	3.584730e-01	5.028815e-01	X	18902792	18902817	26	-	0.479	0.313	-0.931
ENSG00000044446	E024	3.052949	0.0056302031	3.672545e-01	5.116317e-01	X	18902818	18902910	93	-	0.665	0.528	-0.610
ENSG00000044446	E025	97.381372	0.0004537895	1.614891e-01	2.770477e-01	X	18905758	18905859	102	-	1.938	1.996	0.196
ENSG00000044446	E026	98.579288	0.0032678760	3.506270e-02	8.176922e-02	X	18906495	18906624	130	-	1.913	2.016	0.345
ENSG00000044446	E027	84.281005	0.0004947173	5.424494e-02	1.166768e-01	X	18906736	18906814	79	-	1.856	1.940	0.282
ENSG00000044446	E028	75.214588	0.0023422749	7.222204e-02	1.470340e-01	X	18907018	18907097	80	-	1.799	1.889	0.304
ENSG00000044446	E029	103.848760	0.0037301524	8.633882e-01	9.158760e-01	X	18907900	18908056	157	-	1.993	2.005	0.040
ENSG00000044446	E030	98.725464	0.0026477350	5.446573e-01	6.751004e-01	X	18908801	18908934	134	-	1.993	1.971	-0.075
ENSG00000044446	E031	87.225713	0.0003110344	3.276980e-01	4.711738e-01	X	18910872	18910960	89	-	1.948	1.916	-0.109
ENSG00000044446	E032	132.832694	0.0003067901	2.937650e-04	1.354415e-03	X	18918681	18918854	174	-	2.176	2.068	-0.359
ENSG00000044446	E033	118.685819	0.0005046693	3.009567e-03	1.029418e-02	X	18920032	18920201	170	-	2.121	2.027	-0.314
ENSG00000044446	E034	75.549281	0.0007799060	3.500229e-01	4.941981e-01	X	18924056	18924134	79	-	1.891	1.857	-0.114
ENSG00000044446	E035	16.261238	0.0057562968	4.366492e-08	4.765360e-07	X	18924164	18924380	217	-	1.465	0.975	-1.739
ENSG00000044446	E036	93.028664	0.0005638658	1.375472e-01	2.446706e-01	X	18924381	18924525	145	-	1.989	1.938	-0.171
ENSG00000044446	E037	75.633402	0.0032183638	5.885288e-02	1.246646e-01	X	18925668	18925777	110	-	1.919	1.832	-0.295
ENSG00000044446	E038	81.253353	0.0016931965	2.580696e-04	1.208815e-03	X	18926453	18926587	135	-	1.987	1.834	-0.517
ENSG00000044446	E039	64.838180	0.0015192298	4.318283e-03	1.403644e-02	X	18929228	18929306	79	-	1.875	1.745	-0.440
ENSG00000044446	E040	67.690331	0.0023958954	2.928613e-02	7.055688e-02	X	18931641	18931748	108	-	1.877	1.775	-0.345
ENSG00000044446	E041	62.157065	0.0012924133	6.758808e-02	1.393459e-01	X	18936055	18936150	96	-	1.831	1.749	-0.278
ENSG00000044446	E042	2.217416	0.0067589219	4.201831e-01	5.634110e-01	X	18936151	18936201	51	-	0.582	0.454	-0.613
ENSG00000044446	E043	66.014553	0.0063707299	4.089228e-03	1.339232e-02	X	18938627	18938749	123	-	1.904	1.741	-0.550
ENSG00000044446	E044	40.499541	0.0216727459	8.358672e-02	1.651587e-01	X	18939995	18940048	54	-	1.689	1.533	-0.530
ENSG00000044446	E045	70.470945	0.0004276078	2.347109e-05	1.432100e-04	X	18941529	18941675	147	-	1.938	1.764	-0.585
ENSG00000044446	E046	58.652656	0.0003886135	9.339579e-05	4.909148e-04	X	18943710	18943808	99	-	1.861	1.687	-0.587
ENSG00000044446	E047	55.425292	0.0010954152	8.653304e-05	4.588252e-04	X	18945078	18945158	81	-	1.844	1.658	-0.629
ENSG00000044446	E048	49.508700	0.0081963316	2.428300e-04	1.145190e-03	X	18948744	18948826	83	-	1.821	1.584	-0.803
ENSG00000044446	E049	65.821106	0.0095279943	2.936924e-02	7.071394e-02	X	18951104	18951272	169	-	1.887	1.750	-0.461
ENSG00000044446	E050	41.739024	0.0162648853	2.966547e-02	7.130575e-02	X	18952494	18952541	48	-	1.714	1.540	-0.592
ENSG00000044446	E051	62.919907	0.0167494267	1.032815e-02	2.957700e-02	X	18954254	18954412	159	-	1.898	1.711	-0.633
ENSG00000044446	E052	52.364725	0.0017274433	2.133686e-07	2.034325e-06	X	18983855	18984043	189	-	1.861	1.601	-0.879
ENSG00000044446	E053	22.128074	0.0009542005	3.096540e-07	2.856456e-06	X	18984044	18984156	113	-	1.551	1.189	-1.257
ENSG00000044446	E054	4.838624	0.0640830342	1.563885e-01	2.703242e-01	X	18984727	18984835	109	-	0.893	0.647	-0.991

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000044446

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3