ENSG00000044446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379942 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding protein_coding 19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 2.881584 4.315149 2.522785 0.92417127 0.4707348 -0.772025348 0.14997083 0.21050000 0.14933333 -0.06116667 0.6291374823 0.0005493942 FALSE  
ENST00000464455 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding processed_transcript 19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 1.689231 1.011334 2.141250 0.19486750 0.2650499 1.074720888 0.08852083 0.04960000 0.12703333 0.07743333 0.0045638485 0.0005493942 FALSE  
ENST00000469485 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding processed_transcript 19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 5.428609 6.125798 3.958168 0.80338995 0.1048491 -0.628777877 0.27581250 0.29850000 0.23563333 -0.06286667 0.4617167841 0.0005493942 FALSE  
MSTRG.33970.16 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding   19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 1.920772 1.067148 2.277626 0.06013039 0.3088826 1.086635245 0.10388333 0.05206667 0.13590000 0.08383333 0.0005493942 0.0005493942 FALSE  
MSTRG.33970.2 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding   19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 1.361836 1.697731 0.644612 0.52309796 0.3291224 -1.383368496 0.07011667 0.08283333 0.03893333 -0.04390000 0.6385274191 0.0005493942 FALSE  
MSTRG.33970.4 ENSG00000044446 HEK293_OSMI2_2hA HEK293_TMG_2hB PHKA2 protein_coding   19.09242 20.48515 16.80175 0.2779429 0.2753441 -0.2858125 2.790548 2.865104 2.869495 0.48656235 0.4053228 0.002201495 0.15679167 0.14043333 0.17016667 0.02973333 0.7216289871 0.0005493942 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000044446 E001 2.902505 0.0288555353 3.949663e-01 5.388068e-01 X 18892241 18892297 57 - 0.665 0.527 -0.613
ENSG00000044446 E002 87.093461 0.0003416330 2.077878e-04 9.972330e-04 X 18892298 18892971 674 - 1.823 1.979 0.523
ENSG00000044446 E003 19.882710 0.0009126687 2.874007e-01 4.278960e-01 X 18892972 18892972 1 - 1.243 1.333 0.316
ENSG00000044446 E004 292.205383 0.0004492863 2.792997e-22 2.292569e-20 X 18892973 18893447 475 - 2.282 2.519 0.793
ENSG00000044446 E005 123.312327 0.0063096100 4.766545e-06 3.409763e-05 X 18893448 18893521 74 - 1.904 2.148 0.817
ENSG00000044446 E006 145.762616 0.0025993149 2.066023e-06 1.602202e-05 X 18893522 18893655 134 - 2.015 2.209 0.650
ENSG00000044446 E007 3.295412 0.0053332242 6.063351e-01 7.265184e-01 X 18894082 18894203 122 - 0.665 0.591 -0.323
ENSG00000044446 E008 173.826487 0.0052967230 1.313426e-03 5.022095e-03 X 18894204 18894404 201 - 2.121 2.272 0.504
ENSG00000044446 E009 1.213603 0.0108647759 5.581101e-01 6.863982e-01 X 18894405 18895137 733 - 0.256 0.365 0.711
ENSG00000044446 E010 71.831964 0.0043167818 3.913045e-02 8.942924e-02 X 18895138 18895145 8 - 1.764 1.880 0.392
ENSG00000044446 E011 80.733315 0.0045556421 8.552839e-04 3.456434e-03 X 18895146 18895191 46 - 1.767 1.951 0.618
ENSG00000044446 E012 11.866020 0.0014510309 2.643220e-01 4.022800e-01 X 18895192 18896634 1443 - 1.155 1.052 -0.370
ENSG00000044446 E013 137.263570 0.0084723310 3.591377e-03 1.198541e-02 X 18897163 18897333 171 - 2.007 2.174 0.560
ENSG00000044446 E014 75.403999 0.0093265702 4.108090e-02 9.303465e-02 X 18897334 18897823 490 - 1.936 1.816 -0.405
ENSG00000044446 E015 39.860494 0.0190777029 9.439081e-01 9.688285e-01 X 18897824 18897973 150 - 1.589 1.588 -0.003
ENSG00000044446 E016 68.317419 0.0111891961 4.240984e-01 5.670916e-01 X 18897974 18898421 448 - 1.849 1.800 -0.164
ENSG00000044446 E017 29.579191 0.0149262846 1.371486e-01 2.441185e-01 X 18898971 18899148 178 - 1.546 1.418 -0.439
ENSG00000044446 E018 14.761446 0.0311102374 6.019860e-01 7.230312e-01 X 18899149 18899172 24 - 1.142 1.206 0.230
ENSG00000044446 E019 53.921746 0.0047722144 5.615980e-02 1.199863e-01 X 18899173 18899226 54 - 1.644 1.764 0.408
ENSG00000044446 E020 39.627248 0.0102730807 3.290337e-01 4.725244e-01 X 18900670 18900678 9 - 1.541 1.624 0.282
ENSG00000044446 E021 48.778484 0.0082513168 6.000342e-01 7.213273e-01 X 18900679 18900699 21 - 1.655 1.699 0.147
ENSG00000044446 E022 101.393247 0.0003257008 2.385239e-01 3.724265e-01 X 18901485 18901603 119 - 1.963 2.012 0.163
ENSG00000044446 E023 1.471569 0.0448437186 3.584730e-01 5.028815e-01 X 18902792 18902817 26 - 0.479 0.313 -0.931
ENSG00000044446 E024 3.052949 0.0056302031 3.672545e-01 5.116317e-01 X 18902818 18902910 93 - 0.665 0.528 -0.610
ENSG00000044446 E025 97.381372 0.0004537895 1.614891e-01 2.770477e-01 X 18905758 18905859 102 - 1.938 1.996 0.196
ENSG00000044446 E026 98.579288 0.0032678760 3.506270e-02 8.176922e-02 X 18906495 18906624 130 - 1.913 2.016 0.345
ENSG00000044446 E027 84.281005 0.0004947173 5.424494e-02 1.166768e-01 X 18906736 18906814 79 - 1.856 1.940 0.282
ENSG00000044446 E028 75.214588 0.0023422749 7.222204e-02 1.470340e-01 X 18907018 18907097 80 - 1.799 1.889 0.304
ENSG00000044446 E029 103.848760 0.0037301524 8.633882e-01 9.158760e-01 X 18907900 18908056 157 - 1.993 2.005 0.040
ENSG00000044446 E030 98.725464 0.0026477350 5.446573e-01 6.751004e-01 X 18908801 18908934 134 - 1.993 1.971 -0.075
ENSG00000044446 E031 87.225713 0.0003110344 3.276980e-01 4.711738e-01 X 18910872 18910960 89 - 1.948 1.916 -0.109
ENSG00000044446 E032 132.832694 0.0003067901 2.937650e-04 1.354415e-03 X 18918681 18918854 174 - 2.176 2.068 -0.359
ENSG00000044446 E033 118.685819 0.0005046693 3.009567e-03 1.029418e-02 X 18920032 18920201 170 - 2.121 2.027 -0.314
ENSG00000044446 E034 75.549281 0.0007799060 3.500229e-01 4.941981e-01 X 18924056 18924134 79 - 1.891 1.857 -0.114
ENSG00000044446 E035 16.261238 0.0057562968 4.366492e-08 4.765360e-07 X 18924164 18924380 217 - 1.465 0.975 -1.739
ENSG00000044446 E036 93.028664 0.0005638658 1.375472e-01 2.446706e-01 X 18924381 18924525 145 - 1.989 1.938 -0.171
ENSG00000044446 E037 75.633402 0.0032183638 5.885288e-02 1.246646e-01 X 18925668 18925777 110 - 1.919 1.832 -0.295
ENSG00000044446 E038 81.253353 0.0016931965 2.580696e-04 1.208815e-03 X 18926453 18926587 135 - 1.987 1.834 -0.517
ENSG00000044446 E039 64.838180 0.0015192298 4.318283e-03 1.403644e-02 X 18929228 18929306 79 - 1.875 1.745 -0.440
ENSG00000044446 E040 67.690331 0.0023958954 2.928613e-02 7.055688e-02 X 18931641 18931748 108 - 1.877 1.775 -0.345
ENSG00000044446 E041 62.157065 0.0012924133 6.758808e-02 1.393459e-01 X 18936055 18936150 96 - 1.831 1.749 -0.278
ENSG00000044446 E042 2.217416 0.0067589219 4.201831e-01 5.634110e-01 X 18936151 18936201 51 - 0.582 0.454 -0.613
ENSG00000044446 E043 66.014553 0.0063707299 4.089228e-03 1.339232e-02 X 18938627 18938749 123 - 1.904 1.741 -0.550
ENSG00000044446 E044 40.499541 0.0216727459 8.358672e-02 1.651587e-01 X 18939995 18940048 54 - 1.689 1.533 -0.530
ENSG00000044446 E045 70.470945 0.0004276078 2.347109e-05 1.432100e-04 X 18941529 18941675 147 - 1.938 1.764 -0.585
ENSG00000044446 E046 58.652656 0.0003886135 9.339579e-05 4.909148e-04 X 18943710 18943808 99 - 1.861 1.687 -0.587
ENSG00000044446 E047 55.425292 0.0010954152 8.653304e-05 4.588252e-04 X 18945078 18945158 81 - 1.844 1.658 -0.629
ENSG00000044446 E048 49.508700 0.0081963316 2.428300e-04 1.145190e-03 X 18948744 18948826 83 - 1.821 1.584 -0.803
ENSG00000044446 E049 65.821106 0.0095279943 2.936924e-02 7.071394e-02 X 18951104 18951272 169 - 1.887 1.750 -0.461
ENSG00000044446 E050 41.739024 0.0162648853 2.966547e-02 7.130575e-02 X 18952494 18952541 48 - 1.714 1.540 -0.592
ENSG00000044446 E051 62.919907 0.0167494267 1.032815e-02 2.957700e-02 X 18954254 18954412 159 - 1.898 1.711 -0.633
ENSG00000044446 E052 52.364725 0.0017274433 2.133686e-07 2.034325e-06 X 18983855 18984043 189 - 1.861 1.601 -0.879
ENSG00000044446 E053 22.128074 0.0009542005 3.096540e-07 2.856456e-06 X 18984044 18984156 113 - 1.551 1.189 -1.257
ENSG00000044446 E054 4.838624 0.0640830342 1.563885e-01 2.703242e-01 X 18984727 18984835 109 - 0.893 0.647 -0.991