ENSG00000044115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302763 ENSG00000044115 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNA1 protein_coding protein_coding 67.25738 68.53264 73.15663 2.054394 0.5935679 0.09418412 51.195949 50.689177 57.1655259 3.6369869 0.6796221 0.1734354 0.7575250 0.73926667 0.7815 0.0422333333 7.624661e-01 3.322942e-05 FALSE TRUE
ENST00000521368 ENSG00000044115 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNA1 protein_coding nonsense_mediated_decay 67.25738 68.53264 73.15663 2.054394 0.5935679 0.09418412 5.308130 2.219516 8.3830068 2.2195164 0.2829614 1.9124569 0.0733000 0.03153333 0.1146 0.0830666667 1.057098e-01 3.322942e-05 FALSE FALSE
ENST00000521387 ENSG00000044115 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNA1 protein_coding retained_intron 67.25738 68.53264 73.15663 2.054394 0.5935679 0.09418412 3.626605 3.124966 3.3522090 0.9714018 0.7598666 0.1009594 0.0584375 0.04636667 0.0459 -0.0004666667 9.849274e-01 3.322942e-05 FALSE TRUE
ENST00000540387 ENSG00000044115 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNNA1 protein_coding protein_coding 67.25738 68.53264 73.15663 2.054394 0.5935679 0.09418412 2.344804 8.137532 0.0294418 3.6517770 0.0294418 -7.6904938 0.0348250 0.11913333 0.0004 -0.1187333333 3.322942e-05 3.322942e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000044115 E001 0.0000000       5 138610967 138610977 11 +      
ENSG00000044115 E002 0.0000000       5 138610978 138611089 112 +      
ENSG00000044115 E003 0.0000000       5 138653064 138653122 59 +      
ENSG00000044115 E004 0.0000000       5 138663837 138663876 40 +      
ENSG00000044115 E005 0.0000000       5 138723467 138723625 159 +      
ENSG00000044115 E006 0.4375944 0.0264866686 7.275798e-02 1.479391e-01 5 138753097 138753171 75 + 0.301 0.000 -13.831
ENSG00000044115 E007 1.0684327 0.0122807911 2.097628e-01 3.382613e-01 5 138753417 138753417 1 + 0.426 0.214 -1.389
ENSG00000044115 E008 1.8789878 0.0076838166 5.798343e-02 1.231727e-01 5 138753418 138753420 3 + 0.602 0.291 -1.651
ENSG00000044115 E009 2.5756033 0.0060021029 2.442378e-01 3.791881e-01 5 138753421 138753424 4 + 0.636 0.464 -0.803
ENSG00000044115 E010 7.6708881 0.0316193731 1.096216e-01 2.050118e-01 5 138753425 138753430 6 + 1.041 0.844 -0.742
ENSG00000044115 E011 60.4376020 0.0021390471 5.227975e-08 5.615286e-07 5 138753431 138753444 14 + 1.908 1.652 -0.863
ENSG00000044115 E012 87.6975206 0.0002889442 2.380928e-04 1.125370e-03 5 138753445 138753445 1 + 2.010 1.890 -0.402
ENSG00000044115 E013 200.9913415 0.0003435860 2.669202e-09 3.658460e-08 5 138753446 138753510 65 + 2.374 2.237 -0.455
ENSG00000044115 E014 0.2214452 0.0420063852 5.225962e-01   5 138753661 138754098 438 + 0.000 0.120 11.853
ENSG00000044115 E015 0.1472490 0.0433357699 4.540797e-01   5 138754369 138754438 70 + 0.125 0.000 -12.257
ENSG00000044115 E016 3.3549277 0.0045023152 1.971866e-05 1.224840e-04 5 138754694 138755163 470 + 0.884 0.214 -3.388
ENSG00000044115 E017 1.1362862 0.0113608077 6.243640e-01 7.406909e-01 5 138761941 138762098 158 + 0.368 0.291 -0.481
ENSG00000044115 E018 357.2640084 0.0001768304 3.509809e-20 2.283388e-18 5 138781923 138782029 107 + 2.634 2.475 -0.529
ENSG00000044115 E019 0.5138669 0.0205935229 5.195253e-01 6.536054e-01 5 138782290 138782403 114 + 0.222 0.120 -1.064
ENSG00000044115 E020 532.9761646 0.0007780395 9.732165e-13 2.394765e-11 5 138783177 138783372 196 + 2.791 2.666 -0.416
ENSG00000044115 E021 0.7415557 0.1128342939 1.743413e-01 2.938247e-01 5 138783373 138783374 2 + 0.368 0.119 -2.076
ENSG00000044115 E022 0.0000000       5 138790926 138791043 118 +      
ENSG00000044115 E023 514.1335496 0.0037396184 2.295659e-03 8.136684e-03 5 138810038 138810204 167 + 2.755 2.669 -0.287
ENSG00000044115 E024 0.2214452 0.0420063852 5.225962e-01   5 138811959 138812182 224 + 0.000 0.120 11.853
ENSG00000044115 E025 482.7122960 0.0025071534 2.947332e-02 7.091677e-02 5 138812183 138812302 120 + 2.707 2.661 -0.154
ENSG00000044115 E026 413.3957248 0.0005429165 2.111211e-02 5.383729e-02 5 138824530 138824676 147 + 2.631 2.602 -0.096
ENSG00000044115 E027 388.6191126 0.0011279094 8.671338e-02 1.701442e-01 5 138824677 138824767 91 + 2.602 2.579 -0.075
ENSG00000044115 E028 285.3160731 0.0001705875 1.292836e-01 2.331858e-01 5 138824768 138824799 32 + 2.464 2.451 -0.044
ENSG00000044115 E029 433.1999914 0.0001543177 2.032697e-03 7.328037e-03 5 138827515 138827626 112 + 2.656 2.621 -0.117
ENSG00000044115 E030 395.3241686 0.0001402872 1.736801e-06 1.369425e-05 5 138827627 138827718 92 + 2.633 2.565 -0.227
ENSG00000044115 E031 1.0674006 0.0121989077 6.207765e-01 7.378563e-01 5 138827719 138828232 514 + 0.368 0.291 -0.483
ENSG00000044115 E032 0.0000000       5 138870275 138870459 185 +      
ENSG00000044115 E033 0.0000000       5 138874038 138874158 121 +      
ENSG00000044115 E034 0.0000000       5 138875230 138875265 36 +      
ENSG00000044115 E035 0.0000000       5 138875266 138875398 133 +      
ENSG00000044115 E036 0.0000000       5 138875399 138875399 1 +      
ENSG00000044115 E037 0.0000000       5 138875400 138875431 32 +      
ENSG00000044115 E038 0.0000000       5 138875432 138875432 1 +      
ENSG00000044115 E039 0.0000000       5 138875433 138875434 2 +      
ENSG00000044115 E040 0.0000000       5 138875435 138875436 2 +      
ENSG00000044115 E041 0.0000000       5 138875437 138875439 3 +      
ENSG00000044115 E042 0.0000000       5 138875440 138875442 3 +      
ENSG00000044115 E043 0.0000000       5 138875443 138875463 21 +      
ENSG00000044115 E044 0.0000000       5 138875464 138875487 24 +      
ENSG00000044115 E045 0.0000000       5 138875488 138875597 110 +      
ENSG00000044115 E046 0.0000000       5 138875598 138875606 9 +      
ENSG00000044115 E047 0.0000000       5 138875607 138875652 46 +      
ENSG00000044115 E048 0.1451727 0.0434171603 4.543885e-01   5 138875653 138875738 86 + 0.125 0.000 -12.256
ENSG00000044115 E049 0.0000000       5 138880190 138880194 5 +      
ENSG00000044115 E050 0.0000000       5 138880195 138880213 19 +      
ENSG00000044115 E051 0.0000000       5 138880214 138880288 75 +      
ENSG00000044115 E052 0.0000000       5 138880681 138880733 53 +      
ENSG00000044115 E053 0.1817044 0.0401159165 5.237419e-01   5 138881042 138881044 3 + 0.000 0.120 11.850
ENSG00000044115 E054 0.1817044 0.0401159165 5.237419e-01   5 138881045 138881137 93 + 0.000 0.120 11.850
ENSG00000044115 E055 0.0000000       5 138881138 138881138 1 +      
ENSG00000044115 E056 237.4641326 0.0001957823 9.210084e-03 2.681002e-02 5 138886212 138886228 17 + 2.400 2.358 -0.140
ENSG00000044115 E057 338.5832669 0.0001669259 7.386472e-03 2.222276e-02 5 138886229 138886292 64 + 2.549 2.515 -0.113
ENSG00000044115 E058 554.5656712 0.0010042428 1.881261e-03 6.856601e-03 5 138887490 138887642 153 + 2.769 2.721 -0.159
ENSG00000044115 E059 1.4986628 0.0912600649 4.183010e-01 5.615853e-01 5 138887643 138887732 90 + 0.300 0.463 0.935
ENSG00000044115 E060 0.1451727 0.0434171603 4.543885e-01   5 138891183 138891211 29 + 0.125 0.000 -12.256
ENSG00000044115 E061 411.5451624 0.0006987320 2.716999e-04 1.264655e-03 5 138904349 138904398 50 + 2.645 2.585 -0.199
ENSG00000044115 E062 339.7050309 0.0001737409 2.560326e-02 6.312744e-02 5 138904399 138904441 43 + 2.544 2.518 -0.085
ENSG00000044115 E063 0.5858876 0.0210945042 2.738663e-01 4.129674e-01 5 138904442 138904792 351 + 0.301 0.120 -1.653
ENSG00000044115 E064 521.4900744 0.0005038728 3.928304e-01 5.367262e-01 5 138917742 138917898 157 + 2.715 2.718 0.009
ENSG00000044115 E065 183.0094321 0.0002002150 8.719903e-01 9.216878e-01 5 138924510 138924529 20 + 2.255 2.270 0.049
ENSG00000044115 E066 301.1340304 0.0001693468 5.151502e-01 6.498490e-01 5 138924530 138924588 59 + 2.459 2.491 0.108
ENSG00000044115 E067 502.8889526 0.0001252583 3.609601e-01 5.053268e-01 5 138924589 138924710 122 + 2.681 2.715 0.112
ENSG00000044115 E068 679.3654335 0.0006440613 3.823032e-01 5.265329e-01 5 138925256 138925407 152 + 2.811 2.844 0.112
ENSG00000044115 E069 0.3729606 0.0328882984 9.516776e-01 9.737328e-01 5 138925408 138925491 84 + 0.125 0.120 -0.063
ENSG00000044115 E070 604.9822136 0.0001306771 4.139367e-01 5.573494e-01 5 138929246 138929356 111 + 2.764 2.795 0.104
ENSG00000044115 E071 704.0241720 0.0001116504 3.289349e-05 1.937618e-04 5 138930473 138930637 165 + 2.803 2.880 0.256
ENSG00000044115 E072 301.8157995 0.0006340054 5.893728e-05 3.262104e-04 5 138930638 138930654 17 + 2.414 2.529 0.382
ENSG00000044115 E073 526.1939782 0.0001511135 8.559841e-11 1.528836e-09 5 138930830 138930935 106 + 2.646 2.771 0.416
ENSG00000044115 E074 11.3516370 0.0273383870 8.006943e-01 8.729678e-01 5 138930936 138931074 139 + 1.091 1.075 -0.057
ENSG00000044115 E075 32.7672948 0.0006747768 9.707663e-02 1.860069e-01 5 138931901 138932577 677 + 1.568 1.485 -0.282
ENSG00000044115 E076 596.0277774 0.0008744013 3.933902e-04 1.749451e-03 5 138932578 138932712 135 + 2.722 2.811 0.297
ENSG00000044115 E077 8.3252916 0.0020811276 4.667772e-01 6.063172e-01 5 138932713 138932887 175 + 1.000 0.936 -0.236
ENSG00000044115 E078 5.7443778 0.0032775979 6.706423e-01 7.770333e-01 5 138932888 138932958 71 + 0.845 0.807 -0.149
ENSG00000044115 E079 1928.8183741 0.0020392786 1.404711e-17 6.766294e-16 5 138933802 138935034 1233 + 3.162 3.359 0.654