ENSG00000043514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372818 ENSG00000043514 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIT1 protein_coding protein_coding 14.95722 9.105408 19.16128 1.129805 0.7896116 1.072567 1.7828358 1.642053 3.077791 0.36464707 0.7473827 0.9023155 0.12091250 0.18850000 0.16023333 -0.02826667 8.984309e-01 6.811153e-14 FALSE TRUE
ENST00000441669 ENSG00000043514 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIT1 protein_coding protein_coding 14.95722 9.105408 19.16128 1.129805 0.7896116 1.072567 3.6655893 2.570159 2.947307 0.42604216 0.1800505 0.1968242 0.26164167 0.27960000 0.15393333 -0.12566667 4.108647e-05 6.811153e-14 FALSE TRUE
ENST00000537440 ENSG00000043514 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIT1 protein_coding protein_coding 14.95722 9.105408 19.16128 1.129805 0.7896116 1.072567 3.4241390 2.001770 4.136506 0.40234149 0.7642257 1.0434309 0.22667083 0.22150000 0.21820000 -0.00330000 1.000000e+00 6.811153e-14 TRUE TRUE
MSTRG.932.10 ENSG00000043514 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIT1 protein_coding   14.95722 9.105408 19.16128 1.129805 0.7896116 1.072567 0.6030133 0.000000 1.795723 0.00000000 0.2052766 7.4964328 0.03557917 0.00000000 0.09390000 0.09390000 6.811153e-14 6.811153e-14 TRUE TRUE
MSTRG.932.11 ENSG00000043514 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIT1 protein_coding   14.95722 9.105408 19.16128 1.129805 0.7896116 1.072567 1.0019724 0.203251 1.842959 0.01127643 0.6106969 3.1192064 0.05742083 0.02313333 0.09593333 0.07280000 1.756933e-02 6.811153e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000043514 E001 1.1898730 0.1289231624 1.781257e-01 2.987877e-01 1 39838110 39841021 2912 - 0.434 0.155 -2.002
ENSG00000043514 E002 0.3268771 0.0299756825 6.839624e-01   1 39841022 39841050 29 - 0.095 0.156 0.819
ENSG00000043514 E003 179.5774124 0.0018869501 8.263229e-07 6.986094e-06 1 39841051 39841625 575 - 2.182 2.343 0.536
ENSG00000043514 E004 37.1401331 0.0023420781 8.556866e-04 3.457624e-03 1 39841626 39841644 19 - 1.483 1.689 0.703
ENSG00000043514 E005 58.7969721 0.0048248063 1.255445e-02 3.486118e-02 1 39841645 39841713 69 - 1.709 1.850 0.475
ENSG00000043514 E006 89.0848974 0.0003806222 2.859007e-01 4.262682e-01 1 39841714 39841832 119 - 1.930 1.976 0.157
ENSG00000043514 E007 91.2627152 0.0002972729 4.215556e-01 5.646902e-01 1 39841833 39841913 81 - 1.946 1.982 0.123
ENSG00000043514 E008 95.6487625 0.0003110736 6.424535e-01 7.552365e-01 1 39844101 39844195 95 - 1.970 1.994 0.079
ENSG00000043514 E009 62.8939188 0.0004088307 4.934345e-01 6.304651e-01 1 39844196 39844218 23 - 1.809 1.786 -0.080
ENSG00000043514 E010 93.6687633 0.0025490550 3.384060e-01 4.822773e-01 1 39844531 39844640 110 - 1.985 1.949 -0.122
ENSG00000043514 E011 0.6934950 0.1212664548 5.795110e-01 7.044164e-01 1 39847044 39847219 176 - 0.173 0.272 0.834
ENSG00000043514 E012 61.7294338 0.0030614116 6.217072e-01 7.386538e-01 1 39847220 39847280 61 - 1.800 1.779 -0.070
ENSG00000043514 E013 39.5948407 0.0005741281 4.175289e-01 5.608635e-01 1 39847281 39847297 17 - 1.620 1.581 -0.131
ENSG00000043514 E014 50.7365302 0.0004825618 1.469975e-01 2.575940e-01 1 39847548 39847593 46 - 1.736 1.670 -0.223
ENSG00000043514 E015 58.3538002 0.0005243027 5.485538e-02 1.177479e-01 1 39847594 39847660 67 - 1.803 1.719 -0.282
ENSG00000043514 E016 8.3787515 0.0020701515 4.015793e-01 5.452838e-01 1 39847661 39847747 87 - 0.922 1.021 0.370
ENSG00000043514 E017 0.8899626 0.0368573940 8.568587e-01 9.115323e-01 1 39847748 39847757 10 - 0.297 0.270 -0.188
ENSG00000043514 E018 75.3356603 0.0003647517 9.615827e-01 9.797928e-01 1 39847986 39848091 106 - 1.875 1.884 0.030
ENSG00000043514 E019 36.1173904 0.0005509864 8.060906e-01 8.767299e-01 1 39848092 39848097 6 - 1.569 1.561 -0.025
ENSG00000043514 E020 31.1456170 0.0007614460 6.920109e-01 7.933445e-01 1 39850119 39850122 4 - 1.487 1.518 0.109
ENSG00000043514 E021 70.8699815 0.0004294396 6.074566e-02 1.278790e-01 1 39850123 39850261 139 - 1.879 1.807 -0.245
ENSG00000043514 E022 8.7432095 0.0020092900 6.820987e-01 7.856084e-01 1 39851642 39851770 129 - 1.003 0.964 -0.144
ENSG00000043514 E023 1.8217435 0.0092709321 1.336248e-01 2.391913e-01 1 39852558 39852730 173 - 0.538 0.270 -1.505
ENSG00000043514 E024 50.4862833 0.0005311799 6.206365e-03 1.915789e-02 1 39852731 39852876 146 - 1.753 1.619 -0.454
ENSG00000043514 E025 45.2390732 0.0005173039 2.581574e-04 1.209136e-03 1 39853970 39854068 99 - 1.728 1.535 -0.657
ENSG00000043514 E026 52.0627771 0.0004244236 5.404289e-04 2.311381e-03 1 39857277 39857417 141 - 1.782 1.615 -0.568
ENSG00000043514 E027 0.2966881 0.0273867382 4.066955e-01   1 39862788 39862823 36 - 0.173 0.000 -10.468
ENSG00000043514 E028 0.4031496 0.0292474106 8.764340e-02 1.715532e-01 1 39864710 39865667 958 - 0.000 0.271 11.832
ENSG00000043514 E029 0.4449813 0.0213440201 9.477080e-01 9.711113e-01 1 39876062 39876132 71 - 0.173 0.156 -0.184
ENSG00000043514 E030 45.3693433 0.0007476149 6.376935e-02 1.329706e-01 1 39883318 39883511 194 - 1.701 1.610 -0.311