ENSG00000043355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376335 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding protein_coding 64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 12.1665101 12.82011079 10.704944 1.88927577 0.6750638 -0.25990927 0.19638750 0.1364666667 0.26440000 0.12793333 0.003141687 0.002320096 FALSE TRUE
ENST00000468291 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding processed_transcript 64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 5.7143904 14.94368188 2.320555 1.30443679 1.2627205 -2.68175529 0.07845417 0.1588000000 0.05480000 -0.10400000 0.507517785 0.002320096 FALSE FALSE
ENST00000477213 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding processed_transcript 64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 6.2706851 4.64487840 4.484026 0.42119400 0.4333979 -0.05073487 0.10315833 0.0498666667 0.11143333 0.06156667 0.002320096 0.002320096   FALSE
ENST00000481565 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding processed_transcript 64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 26.9617328 46.41902284 12.029271 1.92181737 1.5968967 -1.94727889 0.39522917 0.4959000000 0.29630000 -0.19960000 0.002504804 0.002320096 FALSE FALSE
MSTRG.9022.3 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding   64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 0.8130979 0.08288636 3.827194 0.08288636 2.3224569 5.36844125 0.01917500 0.0009333333 0.09243333 0.09150000 0.271235389 0.002320096 FALSE TRUE
MSTRG.9022.4 ENSG00000043355 HEK293_OSMI2_2hA HEK293_TMG_2hB ZIC2 protein_coding   64.81984 93.76832 40.53171 4.095955 1.695363 -1.209848 9.7235126 12.13409751 4.881066 0.89133666 2.5621085 -1.31203443 0.15310000 0.1291333333 0.12403333 -0.00510000 0.889902271 0.002320096 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000043355 E001 31.09489 0.0253179787 8.578938e-03 2.523608e-02 13 99981784 99981808 25 + 1.605 1.400 -0.706
ENSG00000043355 E002 95.22779 0.0271751541 1.267541e-04 6.445452e-04 13 99981809 99982120 312 + 2.115 1.846 -0.906
ENSG00000043355 E003 71.10954 0.0240744465 2.028553e-06 1.576047e-05 13 99982121 99982235 115 + 2.028 1.680 -1.175
ENSG00000043355 E004 659.24733 0.0029534234 2.133074e-06 1.648935e-05 13 99982236 99983139 904 + 2.838 2.770 -0.228
ENSG00000043355 E005 16.25406 0.0058135575 4.511728e-02 1.004142e-01 13 99984289 99984390 102 + 1.301 1.163 -0.488
ENSG00000043355 E006 10.62967 0.0017208778 1.039179e-01 1.964745e-01 13 99984391 99984409 19 + 1.114 0.988 -0.460
ENSG00000043355 E007 31.33088 0.0127358097 3.641695e-04 1.635357e-03 13 99984410 99984688 279 + 1.635 1.382 -0.865
ENSG00000043355 E008 15.02622 0.0123290762 1.628882e-04 8.043027e-04 13 99984689 99984737 49 + 1.375 1.041 -1.187
ENSG00000043355 E009 22.72090 0.0061436301 2.768193e-03 9.577611e-03 13 99984789 99984945 157 + 1.476 1.282 -0.675
ENSG00000043355 E010 431.21392 0.0017354299 9.625662e-01 9.803764e-01 13 99984946 99985109 164 + 2.578 2.626 0.159
ENSG00000043355 E011 17.28351 0.0010357372 7.762751e-01 8.559425e-01 13 99985286 99985322 37 + 1.223 1.241 0.062
ENSG00000043355 E012 241.98469 0.0002182791 1.959582e-01 3.211619e-01 13 99985323 99985451 129 + 2.350 2.364 0.046
ENSG00000043355 E013 53.23796 0.0192583820 1.403625e-01 2.485303e-01 13 99985452 99985454 3 + 1.754 1.680 -0.249
ENSG00000043355 E014 48.41890 0.0285466753 4.045242e-04 1.791982e-03 13 99985455 99985493 39 + 1.839 1.546 -0.996
ENSG00000043355 E015 19.80411 0.0334512767 2.049254e-15 7.428722e-14 13 99985494 99985542 49 + 1.678 0.731 -3.410
ENSG00000043355 E016 13.44453 0.3066657589 1.584762e-03 5.909465e-03 13 99985543 99985551 9 + 1.462 0.749 -2.603
ENSG00000043355 E017 64.02884 0.0062110469 3.620030e-01 5.064048e-01 13 99985552 99985672 121 + 1.788 1.780 -0.025
ENSG00000043355 E018 110.88336 0.0002701620 1.963543e-15 7.141242e-14 13 99985673 99985865 193 + 1.754 2.111 1.200
ENSG00000043355 E019 1396.51024 0.0068103506 9.244397e-11 1.641045e-09 13 99985866 99986765 900 + 2.962 3.185 0.740