ENSG00000043143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361895 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.08331809 0.06005979 0.03697857 0.03197390 0.03697857 -0.57658388 0.05867500 0.03566667 0.05666667 0.02100000 0.990214725 0.008102052 FALSE TRUE
ENST00000395003 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.06244192 0.18077399 0.04367541 0.06136911 0.02194271 -1.82953136 0.03841250 0.11340000 0.05440000 -0.05900000 0.696261754 0.008102052 FALSE TRUE
ENST00000431355 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.40437060 0.48628553 0.12589112 0.26465724 0.12589112 -1.86871919 0.23742500 0.21696667 0.11626667 -0.10070000 0.723749444 0.008102052 FALSE TRUE
ENST00000453515 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding processed_transcript 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.08148889 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.05292083 0.00000000 0.00000000 0.00000000   0.008102052 FALSE FALSE
ENST00000512386 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.21664063 0.30399555 0.29464079 0.15767017 0.06277396 -0.04363499 0.19084167 0.18370000 0.37976667 0.19606667 0.528264688 0.008102052 FALSE TRUE
ENST00000612830 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.17355417 0.40230989 0.00000000 0.16218831 0.00000000 -5.36565717 0.09891667 0.19106667 0.00000000 -0.19106667 0.008102052 0.008102052 FALSE TRUE
ENST00000681547 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding protein_coding 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.08128827 0.19386648 0.06199538 0.10177550 0.06199538 -1.50164832 0.07722083 0.13313333 0.09696667 -0.03616667 0.806884042 0.008102052 FALSE TRUE
ENST00000681792 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding retained_intron 1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.04857103 0.01265425 0.06170263 0.01265425 0.03139482 1.66224442 0.04144167 0.00590000 0.07783333 0.07193333 0.136000791 0.008102052 FALSE TRUE
MSTRG.26932.1 ENSG00000043143 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE2 protein_coding   1.452714 1.880481 0.791614 0.3471581 0.1456823 -1.237774 0.14456936 0.00000000 0.05868229 0.00000000 0.05868229 2.77993814 0.08905417 0.00000000 0.09180000 0.09180000 0.673827717 0.008102052 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000043143 E001 0.4720498 0.248463413 0.21000625 0.33854722 5 134524312 134524429 118 + 0.316 0.078 -2.440
ENSG00000043143 E002 0.0000000       5 134525657 134525661 5 +      
ENSG00000043143 E003 0.0000000       5 134525662 134525669 8 +      
ENSG00000043143 E004 0.0000000       5 134525670 134525672 3 +      
ENSG00000043143 E005 0.5869318 0.408764451 0.43277802 0.57523678 5 134525673 134525741 69 + 0.316 0.140 -1.497
ENSG00000043143 E006 0.5869318 0.408764451 0.43277802 0.57523678 5 134525742 134525742 1 + 0.316 0.140 -1.497
ENSG00000043143 E007 1.6198875 0.011790660 0.82711185 0.89128339 5 134525743 134525996 254 + 0.417 0.376 -0.228
ENSG00000043143 E008 1.3598328 0.010486105 0.90413580 0.94299438 5 134525997 134526001 5 + 0.317 0.339 0.137
ENSG00000043143 E009 1.3598328 0.010486105 0.90413580 0.94299438 5 134526002 134526011 10 + 0.317 0.339 0.137
ENSG00000043143 E010 0.0000000       5 134526012 134526107 96 +      
ENSG00000043143 E011 0.6589510 0.019122536 0.95811528 0.97774689 5 134526108 134526175 68 + 0.187 0.202 0.136
ENSG00000043143 E012 1.3586869 0.009835445 0.32542398 0.46887219 5 134526176 134526218 43 + 0.187 0.376 1.359
ENSG00000043143 E013 1.9435409 0.007876742 0.14156524 0.25017359 5 134526219 134526249 31 + 0.187 0.473 1.874
ENSG00000043143 E014 2.0929800 0.007369969 0.40439787 0.54810528 5 134526250 134526286 37 + 0.317 0.473 0.874
ENSG00000043143 E015 0.6245948 0.038193257 0.38107551 0.52536540 5 134526637 134526758 122 + 0.000 0.203 10.050
ENSG00000043143 E016 8.2140512 0.049530401 0.63178243 0.74674190 5 134535858 134535915 58 + 0.839 0.919 0.304
ENSG00000043143 E017 0.3268771 0.029269950 0.46536217   5 134535916 134536022 107 + 0.187 0.078 -1.447
ENSG00000043143 E018 0.4482035 0.040476483 0.01046639 0.02990058 5 134536650 134536790 141 + 0.417 0.000 -12.714
ENSG00000043143 E019 11.1096186 0.012719957 0.60549652 0.72587700 5 134537989 134538083 95 + 0.957 1.022 0.239
ENSG00000043143 E020 0.0000000       5 134544436 134544538 103 +      
ENSG00000043143 E021 16.4361790 0.001774962 0.62653270 0.74247787 5 134552052 134552209 158 + 1.126 1.171 0.160
ENSG00000043143 E022 0.0000000       5 134553399 134553496 98 +      
ENSG00000043143 E023 18.0812724 0.001521445 0.95625439 0.97660648 5 134559830 134559990 161 + 1.205 1.199 -0.024
ENSG00000043143 E024 18.7087893 0.001817258 0.68101531 0.78483134 5 134560746 134560957 212 + 1.247 1.209 -0.134
ENSG00000043143 E025 12.7322857 0.001557015 0.43159790 0.57414625 5 134562200 134562367 168 + 1.006 1.087 0.298
ENSG00000043143 E026 0.4847352 0.286470174 0.21819885 0.34823088 5 134562368 134563282 915 + 0.318 0.078 -2.448
ENSG00000043143 E027 0.3697384 0.025199921 0.64001443 0.75334154 5 134564172 134564493 322 + 0.000 0.144 9.545
ENSG00000043143 E028 11.7195494 0.030070477 0.23589431 0.36942894 5 134564494 134564610 117 + 0.902 1.063 0.594
ENSG00000043143 E029 24.7664417 0.001106179 0.18053968 0.30185867 5 134566116 134566580 465 + 1.247 1.352 0.368
ENSG00000043143 E030 10.7411661 0.002299514 0.76760360 0.84980919 5 134573645 134573762 118 + 1.028 0.994 -0.126
ENSG00000043143 E031 2.1682970 0.008076990 0.62884140 0.74431987 5 134573763 134575737 1975 + 0.498 0.412 -0.445
ENSG00000043143 E032 10.0932753 0.001870252 0.97341216 0.98739064 5 134576768 134576896 129 + 0.982 0.976 -0.022
ENSG00000043143 E033 1.3179019 0.199054719 0.92961517 0.95965970 5 134576897 134577038 142 + 0.317 0.336 0.123
ENSG00000043143 E034 3.7726450 0.006454925 0.09229902 0.17871439 5 134578494 134578496 3 + 0.805 0.551 -1.070
ENSG00000043143 E035 122.7834324 0.001071562 0.22117710 0.35183416 5 134578497 134583230 4734 + 2.046 2.010 -0.120