ENSG00000043093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292782 ENSG00000043093 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D1 protein_coding protein_coding 7.274849 1.32352 13.06127 0.144499 0.4000936 3.293088 0.8185510 0.3634570 1.4678776 0.06286455 0.07165717 1.984513 0.15480833 0.2734 0.11290000 -0.16050000 0.0019049011 0.0001141025 FALSE TRUE
ENST00000460412 ENSG00000043093 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D1 protein_coding protein_coding 7.274849 1.32352 13.06127 0.144499 0.4000936 3.293088 0.9307433 0.1021720 1.8424952 0.07168400 0.28006900 4.045685 0.13800000 0.0926 0.14170000 0.04910000 0.6029106127 0.0001141025 FALSE TRUE
ENST00000469954 ENSG00000043093 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D1 protein_coding protein_coding 7.274849 1.32352 13.06127 0.144499 0.4000936 3.293088 0.9018791 0.0000000 0.4206517 0.00000000 0.42065175 5.428450 0.07291250 0.0000 0.03063333 0.03063333 0.9935316048 0.0001141025 FALSE TRUE
ENST00000492563 ENSG00000043093 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D1 protein_coding nonsense_mediated_decay 7.274849 1.32352 13.06127 0.144499 0.4000936 3.293088 0.6382724 0.0000000 2.3308715 0.00000000 0.45976586 7.870902 0.06075833 0.0000 0.18040000 0.18040000 0.0001141025 0.0001141025 FALSE FALSE
ENST00000632685 ENSG00000043093 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D1 protein_coding protein_coding 7.274849 1.32352 13.06127 0.144499 0.4000936 3.293088 3.6933410 0.8057744 6.8425524 0.14144176 0.45511384 3.070399 0.53827917 0.5989 0.52293333 -0.07596667 0.4808352887 0.0001141025 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000043093 E001 88.5943472 0.0019917117 3.358294e-10 5.416933e-09 3 182938074 182942775 4702 - 1.756 2.053 1.000
ENSG00000043093 E002 80.4359874 0.0003692983 3.831387e-03 1.266922e-02 3 182942776 182943775 1000 - 1.748 1.894 0.493
ENSG00000043093 E003 194.1150686 0.0002337742 3.255057e-01 4.689435e-01 3 182943776 182945033 1258 - 2.157 2.130 -0.091
ENSG00000043093 E004 44.4024855 0.0006451242 9.875448e-01 9.962921e-01 3 182945034 182945103 70 - 1.521 1.524 0.012
ENSG00000043093 E005 50.9144219 0.0022274488 2.570973e-01 3.941406e-01 3 182945104 182945173 70 - 1.592 1.513 -0.268
ENSG00000043093 E006 53.2830647 0.0023193667 3.516662e-01 4.959030e-01 3 182947238 182947334 97 - 1.608 1.545 -0.214
ENSG00000043093 E007 43.4722764 0.0005396557 8.211964e-01 8.872811e-01 3 182947550 182947632 83 - 1.514 1.502 -0.041
ENSG00000043093 E008 55.4616921 0.0004752588 4.274336e-01 5.702858e-01 3 182961226 182961314 89 - 1.623 1.575 -0.162
ENSG00000043093 E009 45.0405994 0.0005329635 1.532744e-01 2.661343e-01 3 182961315 182961356 42 - 1.544 1.441 -0.352
ENSG00000043093 E010 49.2288321 0.0015178927 4.415871e-01 5.832295e-01 3 182963881 182963947 67 - 1.574 1.524 -0.171
ENSG00000043093 E011 39.5404446 0.0005380649 8.573331e-01 9.118936e-01 3 182963948 182963999 52 - 1.475 1.467 -0.030
ENSG00000043093 E012 37.0237278 0.0006004243 4.826722e-02 1.061106e-01 3 182964000 182964049 50 - 1.468 1.304 -0.568
ENSG00000043093 E013 52.4760740 0.0004397510 2.000273e-02 5.149549e-02 3 182965537 182965678 142 - 1.616 1.454 -0.555
ENSG00000043093 E014 34.4329800 0.0005733667 4.939407e-02 1.080837e-01 3 182965679 182965753 75 - 1.437 1.267 -0.592
ENSG00000043093 E015 0.3666179 0.0294668415 1.741048e-01 2.934958e-01 3 182980076 182980151 76 - 0.052 0.263 2.707
ENSG00000043093 E016 21.4089165 0.0008928783 3.215200e-01 4.647779e-01 3 182980487 182980538 52 - 1.231 1.130 -0.361
ENSG00000043093 E017 0.0000000       3 182980835 182980935 101 -      
ENSG00000043093 E018 0.0000000       3 182985504 182985622 119 -      
ENSG00000043093 E019 0.0000000       3 182985792 182985820 29 -      
ENSG00000043093 E020 0.0000000       3 182985821 182985953 133 -