ENSG00000042493

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409275 ENSG00000042493 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPG protein_coding protein_coding 15.79371 25.75296 19.80116 0.190732 0.8955225 -0.378985 2.883563 1.006253 7.754624 1.0062533 1.10234413 2.93365615 0.19629583 0.03913333 0.39183333 0.35270000 3.430327e-02 6.341994e-05 FALSE FALSE
ENST00000483659 ENSG00000042493 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPG protein_coding processed_transcript 15.79371 25.75296 19.80116 0.190732 0.8955225 -0.378985 1.551866 2.442364 2.926028 1.7952818 1.48331017 0.25969254 0.10658750 0.09403333 0.14380000 0.04976667 9.144927e-01 6.341994e-05 FALSE TRUE
MSTRG.18766.1 ENSG00000042493 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPG protein_coding   15.79371 25.75296 19.80116 0.190732 0.8955225 -0.378985 8.053596 17.201994 4.523909 1.5402818 0.68234091 -1.92458693 0.47983750 0.66886667 0.22986667 -0.43900000 6.341994e-05 6.341994e-05 FALSE TRUE
MSTRG.18766.2 ENSG00000042493 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPG protein_coding   15.79371 25.75296 19.80116 0.190732 0.8955225 -0.378985 1.392576 2.350207 1.337588 0.5960370 0.11595170 -0.80853361 0.09432917 0.09116667 0.06833333 -0.02283333 7.410770e-01 6.341994e-05 FALSE TRUE
MSTRG.18766.3 ENSG00000042493 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPG protein_coding   15.79371 25.75296 19.80116 0.190732 0.8955225 -0.378985 1.431122 2.404208 2.381994 0.3835593 0.04853453 -0.01333614 0.08038750 0.09320000 0.12083333 0.02763333 5.061699e-01 6.341994e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000042493 E001 1.2136174 0.0780418890 3.727143e-01 5.171313e-01 2 85394728 85394748 21 - 0.455 0.280 -1.031
ENSG00000042493 E002 1.0674006 0.0120779351 2.054574e-01 3.329801e-01 2 85394749 85394752 4 - 0.455 0.227 -1.432
ENSG00000042493 E003 2.6988145 0.0529951252 8.247758e-01 8.896111e-01 2 85394753 85394766 14 - 0.577 0.542 -0.161
ENSG00000042493 E004 22.2286650 0.0349302637 1.263391e-01 2.290499e-01 2 85394767 85394827 61 - 1.186 1.376 0.665
ENSG00000042493 E005 45.3016522 0.0052537063 1.218653e-05 7.935862e-05 2 85394828 85394892 65 - 1.391 1.697 1.047
ENSG00000042493 E006 35.8056404 0.0009103237 2.924742e-06 2.193696e-05 2 85394893 85394894 2 - 1.280 1.601 1.107
ENSG00000042493 E007 54.9974085 0.0009248516 2.227093e-04 1.060757e-03 2 85394895 85394958 64 - 1.564 1.760 0.665
ENSG00000042493 E008 45.8488390 0.0187267370 5.735267e-02 1.220806e-01 2 85395538 85395574 37 - 1.511 1.673 0.553
ENSG00000042493 E009 73.2520985 0.0020725612 1.910750e-03 6.949240e-03 2 85395575 85395626 52 - 1.719 1.868 0.503
ENSG00000042493 E010 0.6256415 0.0175565387 9.368288e-02 1.808800e-01 2 85395980 85396010 31 - 0.378 0.090 -2.600
ENSG00000042493 E011 153.2740934 0.0002620611 1.446722e-02 3.928464e-02 2 85398020 85398131 112 - 2.095 2.164 0.230
ENSG00000042493 E012 96.1383945 0.0004552787 1.179091e-01 2.169365e-01 2 85398132 85398152 21 - 1.906 1.961 0.184
ENSG00000042493 E013 0.3697384 0.0247049372 4.578624e-01 5.981867e-01 2 85398153 85398352 200 - 0.000 0.164 11.932
ENSG00000042493 E014 100.0501672 0.0003623468 3.822583e-02 8.777310e-02 2 85398690 85398719 30 - 1.911 1.984 0.245
ENSG00000042493 E015 136.8051813 0.0002723164 4.420191e-02 9.876536e-02 2 85398720 85398782 63 - 2.055 2.113 0.197
ENSG00000042493 E016 85.5235153 0.0003726683 2.694880e-01 4.079990e-01 2 85399136 85399145 10 - 1.867 1.905 0.129
ENSG00000042493 E017 120.5329208 0.0002865727 1.913539e-01 3.154327e-01 2 85399146 85399180 35 - 2.014 2.052 0.128
ENSG00000042493 E018 181.8714362 0.0002446771 5.706308e-01 6.970677e-01 2 85399181 85399285 105 - 2.215 2.223 0.029
ENSG00000042493 E019 97.9988715 0.0002756641 4.900005e-01 6.273637e-01 2 85401165 85401171 7 - 1.940 1.959 0.064
ENSG00000042493 E020 210.4935681 0.0006664449 9.780052e-02 1.871517e-01 2 85401172 85401329 158 - 2.322 2.270 -0.172
ENSG00000042493 E021 115.1016599 0.0007648018 2.400179e-02 5.981488e-02 2 85401529 85401588 60 - 2.085 1.998 -0.293
ENSG00000042493 E022 103.3356146 0.0037489682 2.422558e-01 3.768497e-01 2 85401589 85401644 56 - 2.019 1.959 -0.204
ENSG00000042493 E023 59.2310569 0.0004619016 2.919712e-01 4.329044e-01 2 85401645 85401650 6 - 1.776 1.718 -0.196
ENSG00000042493 E024 85.7824843 0.0004196124 8.292254e-02 1.641220e-01 2 85401651 85401683 33 - 1.947 1.870 -0.259
ENSG00000042493 E025 1.1156597 0.3432545524 9.909039e-01 9.984419e-01 2 85401684 85401784 101 - 0.285 0.290 0.034
ENSG00000042493 E026 177.3914627 0.0049357163 4.282230e-02 9.621838e-02 2 85401785 85401957 173 - 2.270 2.178 -0.309
ENSG00000042493 E027 0.6986918 0.0172671820 7.202889e-01 8.149277e-01 2 85401958 85402122 165 - 0.165 0.227 0.570
ENSG00000042493 E028 85.8031823 0.0076486382 3.058348e-02 7.311254e-02 2 85402123 85402137 15 - 1.981 1.851 -0.437
ENSG00000042493 E029 83.1469087 0.0016112889 2.040461e-03 7.352389e-03 2 85402138 85402150 13 - 1.975 1.834 -0.476
ENSG00000042493 E030 82.7324191 0.0053357993 1.075310e-02 3.057534e-02 2 85402151 85402158 8 - 1.973 1.832 -0.476
ENSG00000042493 E031 0.0000000       2 85408723 85408815 93 -      
ENSG00000042493 E032 0.1817044 0.0404137253 1.000000e+00   2 85409766 85409832 67 - 0.000 0.090 10.864
ENSG00000042493 E033 0.3289534 0.0298722793 6.177802e-01   2 85410317 85410370 54 - 0.165 0.090 -1.015
ENSG00000042493 E034 0.1817044 0.0404137253 1.000000e+00   2 85413143 85413244 102 - 0.000 0.090 10.864
ENSG00000042493 E035 0.2214452 0.0396262561 1.000000e+00   2 85413833 85413976 144 - 0.000 0.090 10.870
ENSG00000042493 E036 0.2214452 0.0396262561 1.000000e+00   2 85413977 85413983 7 - 0.000 0.090 10.870
ENSG00000042493 E037 0.2214452 0.0396262561 1.000000e+00   2 85413984 85414074 91 - 0.000 0.090 10.870
ENSG00000042493 E038 23.2398790 0.0008452877 6.857511e-04 2.847294e-03 2 85415808 85416025 218 - 1.505 1.254 -0.872
ENSG00000042493 E039 108.2151778 0.0082924458 1.009791e-01 1.919641e-01 2 85418267 85418439 173 - 2.061 1.963 -0.330
ENSG00000042493 E040 16.8609529 0.0284791881 8.223791e-01 8.880221e-01 2 85419407 85419662 256 - 1.186 1.212 0.094