ENSG00000041988

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000054650 ENSG00000041988 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP3 protein_coding protein_coding 35.2077 55.54427 21.39801 2.020806 0.7774907 -1.375747 21.709390 35.308969 11.719174 1.9473741 0.9433263 -1.5903418 0.60461667 0.63480000 0.54760000 -0.08720000 0.266329036 7.811279e-09 FALSE  
ENST00000307896 ENSG00000041988 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP3 protein_coding protein_coding 35.2077 55.54427 21.39801 2.020806 0.7774907 -1.375747 2.443861 3.374601 1.327238 1.7346837 1.0310226 -1.3397298 0.06789167 0.06206667 0.06576667 0.00370000 0.970055472 7.811279e-09 FALSE  
ENST00000472925 ENSG00000041988 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP3 protein_coding protein_coding 35.2077 55.54427 21.39801 2.020806 0.7774907 -1.375747 3.422922 4.717965 2.505982 0.2304356 0.2892951 -0.9100977 0.10197083 0.08510000 0.11643333 0.03133333 0.153538923 7.811279e-09 FALSE  
MSTRG.208.10 ENSG00000041988 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP3 protein_coding   35.2077 55.54427 21.39801 2.020806 0.7774907 -1.375747 2.715905 5.160722 1.449018 1.1890289 0.7256922 -1.8253679 0.07610417 0.09246667 0.06550000 -0.02696667 0.787418113 7.811279e-09 FALSE  
MSTRG.208.12 ENSG00000041988 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP3 protein_coding   35.2077 55.54427 21.39801 2.020806 0.7774907 -1.375747 1.772503 2.643482 2.123803 0.3161581 0.3307925 -0.3144594 0.05684583 0.04730000 0.09850000 0.05120000 0.003651128 7.811279e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000041988 E001 1.722286 0.0544746338 1.255078e-01 2.278807e-01 1 6624868 6624881 14 + 0.576 0.294 -1.517
ENSG00000041988 E002 6.477622 0.0027639716 3.483666e-01 4.925984e-01 1 6624882 6624954 73 + 0.883 0.763 -0.471
ENSG00000041988 E003 6.074469 0.0032108265 7.981132e-01 8.711581e-01 1 6625150 6625168 19 + 0.735 0.777 0.171
ENSG00000041988 E004 4.123381 0.0039705479 1.155654e-01 2.136578e-01 1 6625169 6625170 2 + 0.815 0.588 -0.947
ENSG00000041988 E005 4.604894 0.0034716300 1.122335e-01 2.088061e-01 1 6625171 6625172 2 + 0.850 0.629 -0.904
ENSG00000041988 E006 6.298964 0.0026264260 5.586950e-01 6.868923e-01 1 6625173 6625180 8 + 0.850 0.776 -0.291
ENSG00000041988 E007 9.862479 0.0017226473 8.801841e-01 9.271569e-01 1 6625181 6625191 11 + 0.969 0.956 -0.046
ENSG00000041988 E008 13.697675 0.0013556954 4.575332e-01 5.978679e-01 1 6625192 6625197 6 + 1.017 1.103 0.312
ENSG00000041988 E009 93.595079 0.0018642537 1.724350e-01 2.913678e-01 1 6625198 6625224 27 + 1.933 1.877 -0.187
ENSG00000041988 E010 95.251687 0.0025476869 1.509548e-01 2.629599e-01 1 6625225 6625229 5 + 1.944 1.884 -0.203
ENSG00000041988 E011 161.532224 0.0042989002 8.575312e-01 9.120259e-01 1 6625230 6625292 63 + 2.128 2.127 -0.003
ENSG00000041988 E012 12.668494 0.0015632511 1.318823e-04 6.670949e-04 1 6627763 6628394 632 + 1.309 0.947 -1.303
ENSG00000041988 E013 4.808823 0.0037237309 6.452599e-02 1.342572e-01 1 6628395 6628498 104 + 0.883 0.629 -1.030
ENSG00000041988 E014 372.762935 0.0007044326 1.266584e-01 2.294904e-01 1 6628499 6628691 193 + 2.511 2.483 -0.093
ENSG00000041988 E015 11.671066 0.0016099454 7.165558e-06 4.921665e-05 1 6629643 6629724 82 + 1.321 0.886 -1.572
ENSG00000041988 E016 145.619480 0.0002610303 1.163441e-01 2.147370e-01 1 6630288 6630290 3 + 2.117 2.071 -0.155
ENSG00000041988 E017 249.620738 0.0001771313 3.830038e-01 5.271607e-01 1 6630291 6630353 63 + 2.328 2.312 -0.053
ENSG00000041988 E018 8.069318 0.0022171997 5.625991e-01 6.901729e-01 1 6632370 6632390 21 + 0.815 0.897 0.317
ENSG00000041988 E019 281.971371 0.0001620845 9.694165e-02 1.858164e-01 1 6632391 6632495 105 + 2.333 2.380 0.157
ENSG00000041988 E020 51.770961 0.0005154116 1.880390e-02 4.890304e-02 1 6632496 6632795 300 + 1.733 1.613 -0.409
ENSG00000041988 E021 248.989649 0.0018287584 1.302647e-03 4.985911e-03 1 6632796 6632913 118 + 2.227 2.341 0.380
ENSG00000041988 E022 187.875030 0.0014947163 2.703632e-02 6.607093e-02 1 6632914 6632948 35 + 2.130 2.215 0.284
ENSG00000041988 E023 664.213995 0.0011537158 2.932769e-04 1.352296e-03 1 6632949 6633454 506 + 2.678 2.759 0.268
ENSG00000041988 E024 120.117266 0.0003007621 1.457899e-01 2.559324e-01 1 6633455 6633562 108 + 1.955 2.017 0.209
ENSG00000041988 E025 14.217740 0.0794224767 3.871943e-01 5.313380e-01 1 6633593 6633652 60 + 1.230 1.065 -0.593
ENSG00000041988 E026 165.113615 0.0003897956 7.815300e-09 9.823416e-08 1 6634020 6635586 1567 + 2.266 2.098 -0.563