ENSG00000041802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265245 ENSG00000041802 HEK293_OSMI2_2hA HEK293_TMG_2hB LSG1 protein_coding protein_coding 22.35607 13.03445 31.88545 0.6692735 0.4547933 1.289914 16.223769 11.2984396 21.099061 0.81578583 0.6397720 0.9004625 0.75393750 0.8649000 0.6621667 -0.20273333 0.0000151972 1.51972e-05 FALSE TRUE
ENST00000460584 ENSG00000041802 HEK293_OSMI2_2hA HEK293_TMG_2hB LSG1 protein_coding retained_intron 22.35607 13.03445 31.88545 0.6692735 0.4547933 1.289914 2.907024 1.3049542 4.663997 0.32107201 0.3282180 1.8296442 0.12387500 0.1028333 0.1460667 0.04323333 0.5084884379 1.51972e-05 FALSE FALSE
ENST00000461343 ENSG00000041802 HEK293_OSMI2_2hA HEK293_TMG_2hB LSG1 protein_coding retained_intron 22.35607 13.03445 31.88545 0.6692735 0.4547933 1.289914 1.258911 0.1231405 3.189025 0.06171624 0.6441402 4.5866109 0.04126667 0.0090000 0.0995000 0.09050000 0.0001013338 1.51972e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000041802 E001 599.1155696 0.0084193365 2.900216e-07 2.692792e-06 3 194640791 194642112 1322 - 2.662 2.897 0.782
ENSG00000041802 E002 92.1233868 0.0003518468 7.097473e-03 2.148190e-02 3 194642113 194642172 60 - 1.905 2.040 0.452
ENSG00000041802 E003 111.7818606 0.0011947764 3.382961e-03 1.138776e-02 3 194642173 194642247 75 - 1.984 2.126 0.476
ENSG00000041802 E004 126.0654167 0.0017211056 1.633655e-01 2.795562e-01 3 194644573 194644665 93 - 2.059 2.144 0.284
ENSG00000041802 E005 128.6230001 0.0003101163 9.918167e-01 9.989670e-01 3 194644666 194644746 81 - 2.088 2.123 0.116
ENSG00000041802 E006 132.5489647 0.0028345001 9.848538e-02 1.881904e-01 3 194646164 194646243 80 - 2.126 2.092 -0.113
ENSG00000041802 E007 2.7514600 0.0553687714 2.942298e-01 4.353266e-01 3 194646244 194646444 201 - 0.626 0.452 -0.816
ENSG00000041802 E008 120.1610056 0.0014560101 6.670405e-01 7.743782e-01 3 194648681 194648753 73 - 2.064 2.081 0.059
ENSG00000041802 E009 107.1039422 0.0039314410 9.701761e-01 9.853402e-01 3 194648754 194648804 51 - 2.008 2.037 0.099
ENSG00000041802 E010 17.2428539 0.0021584077 2.484553e-02 6.155694e-02 3 194648805 194649019 215 - 1.298 1.129 -0.600
ENSG00000041802 E011 6.9103740 0.0126293972 1.464389e-03 5.520989e-03 3 194650717 194650783 67 - 1.009 0.575 -1.739
ENSG00000041802 E012 9.8945312 0.0025089978 6.640677e-06 4.597655e-05 3 194650784 194650880 97 - 1.163 0.625 -2.075
ENSG00000041802 E013 134.1363138 0.0002480006 1.767625e-01 2.970297e-01 3 194650881 194651024 144 - 2.122 2.114 -0.027
ENSG00000041802 E014 115.5703723 0.0003035866 6.461286e-01 7.581210e-01 3 194651115 194651216 102 - 2.035 2.085 0.167
ENSG00000041802 E015 9.0936403 0.0019227699 8.855594e-06 5.959313e-05 3 194651217 194651597 381 - 1.128 0.575 -2.169
ENSG00000041802 E016 302.3822379 0.0002418553 4.825445e-03 1.544528e-02 3 194652729 194653142 414 - 2.480 2.455 -0.084
ENSG00000041802 E017 167.4035191 0.0002708301 2.101210e-03 7.537594e-03 3 194658957 194659105 149 - 2.234 2.180 -0.180
ENSG00000041802 E018 85.2869542 0.0004319151 4.617750e-03 1.486953e-02 3 194659106 194659133 28 - 1.953 1.873 -0.270
ENSG00000041802 E019 106.4985743 0.0090121794 2.915399e-02 7.029780e-02 3 194660073 194660133 61 - 2.052 1.960 -0.309
ENSG00000041802 E020 0.7363589 0.0155286533 7.692906e-02 1.545810e-01 3 194660742 194660886 145 - 0.332 0.000 -10.272
ENSG00000041802 E021 116.4497807 0.0049082635 9.058695e-02 1.760530e-01 3 194665557 194665643 87 - 2.076 2.030 -0.155
ENSG00000041802 E022 113.6498619 0.0052614799 1.246642e-01 2.266531e-01 3 194666203 194666289 87 - 2.062 2.019 -0.145
ENSG00000041802 E023 123.5421059 0.0117109667 1.452288e-01 2.551463e-01 3 194666452 194666572 121 - 2.102 2.042 -0.202
ENSG00000041802 E024 91.4846944 0.0164784835 1.466011e-01 2.570638e-01 3 194670009 194670062 54 - 1.977 1.902 -0.252
ENSG00000041802 E025 108.1203801 0.0077162193 3.269252e-02 7.718718e-02 3 194670063 194670135 73 - 2.053 1.966 -0.295
ENSG00000041802 E026 0.0000000       3 194671883 194672022 140 -      
ENSG00000041802 E027 95.2619448 0.0035759784 1.500699e-03 5.638023e-03 3 194672064 194672137 74 - 2.010 1.890 -0.403
ENSG00000041802 E028 70.4342787 0.0052228150 1.207366e-01 2.210189e-01 3 194672138 194672463 326 - 1.858 1.802 -0.189