ENSG00000040531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000046640 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding protein_coding 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 9.268417 11.910934 7.2954293 0.6299093 0.3134604 -0.70645636 0.41280833 0.54460000 0.36800000 -0.17660000 2.271385e-02 6.280707e-24 FALSE TRUE
ENST00000452111 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding protein_coding 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 1.680032 1.410333 1.3969152 0.3725933 0.4364125 -0.01369403 0.07171250 0.06210000 0.06800000 0.00590000 9.656748e-01 6.280707e-24   FALSE
ENST00000467663 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding nonsense_mediated_decay 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 1.543661 1.319730 2.2271115 0.9618994 0.9582937 0.75050427 0.07086667 0.05370000 0.10806667 0.05436667 6.598245e-01 6.280707e-24   FALSE
ENST00000495445 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding retained_intron 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 2.130523 0.605185 1.3304757 0.6051850 0.7603910 1.12365273 0.08536667 0.02360000 0.06733333 0.04373333 5.652425e-01 6.280707e-24   FALSE
ENST00000576979 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding protein_coding 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 2.395553 0.000000 3.5536946 0.0000000 0.7748506 8.47722989 0.10802083 0.00000000 0.17423333 0.17423333 6.280707e-24 6.280707e-24 FALSE FALSE
ENST00000673669 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding protein_coding 22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 1.159820 1.631511 0.3219208 0.8875189 0.1622010 -2.30611366 0.05092083 0.08253333 0.01570000 -0.06683333 7.707363e-01 6.280707e-24 FALSE TRUE
MSTRG.13432.3 ENSG00000040531 HEK293_OSMI2_2hA HEK293_TMG_2hB CTNS protein_coding   22.71525 22.07301 20.02906 2.015363 1.227756 -0.1401223 2.179312 2.785971 1.8052373 0.3672100 0.1074535 -0.62319111 0.09747083 0.12550000 0.09056667 -0.03493333 1.393963e-01 6.280707e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000040531 E001 0.9598778 0.1483535184 4.751241e-01 6.138763e-01 17 3636459 3636465 7 + 0.152 0.309 1.310
ENSG00000040531 E002 37.4042749 0.0052638982 7.270262e-01 8.198953e-01 17 3636466 3636703 238 + 1.520 1.568 0.164
ENSG00000040531 E003 19.3394364 0.0010511940 1.654132e-03 6.135133e-03 17 3636704 3636708 5 + 1.058 1.358 1.064
ENSG00000040531 E004 22.1460880 0.0065799618 3.044596e-02 7.283617e-02 17 3636709 3636724 16 + 1.182 1.397 0.753
ENSG00000040531 E005 20.0425226 0.0131807381 1.918911e-02 4.974641e-02 17 3636725 3636725 1 + 1.104 1.366 0.925
ENSG00000040531 E006 19.2706788 0.0154730372 2.413059e-02 6.008183e-02 17 3636726 3636728 3 + 1.089 1.351 0.926
ENSG00000040531 E007 22.6127386 0.0100596525 4.243796e-02 9.551549e-02 17 3636729 3636738 10 + 1.194 1.406 0.743
ENSG00000040531 E008 32.0843702 0.0010790601 2.479204e-01 3.834795e-01 17 3636739 3636746 8 + 1.423 1.522 0.340
ENSG00000040531 E009 43.5228444 0.0040379463 1.575130e-01 2.718074e-01 17 3636747 3636757 11 + 1.542 1.656 0.387
ENSG00000040531 E010 43.0540169 0.0053638428 1.727097e-01 2.917280e-01 17 3636758 3636759 2 + 1.537 1.651 0.390
ENSG00000040531 E011 41.4759480 0.0021396037 2.145662e-01 3.439374e-01 17 3636760 3636761 2 + 1.531 1.630 0.337
ENSG00000040531 E012 91.4843294 0.0042501005 1.601294e-01 2.752916e-01 17 3636762 3636828 67 + 1.966 1.923 -0.145
ENSG00000040531 E013 64.9535958 0.0045324046 2.197820e-02 5.562954e-02 17 3636829 3636831 3 + 1.855 1.755 -0.338
ENSG00000040531 E014 6.0508543 0.0330848551 5.325023e-01 6.648584e-01 17 3636832 3636887 56 + 0.861 0.788 -0.288
ENSG00000040531 E015 190.6271481 0.0013913003 5.816969e-04 2.466003e-03 17 3637107 3637316 210 + 2.308 2.226 -0.274
ENSG00000040531 E016 0.4847352 0.2220313430 3.603043e-01 5.046322e-01 17 3640147 3640187 41 + 0.264 0.098 -1.720
ENSG00000040531 E017 118.0473919 0.0059420651 7.809312e-03 2.330027e-02 17 3640188 3640267 80 + 2.116 2.009 -0.356
ENSG00000040531 E018 108.7156459 0.0059916333 2.322426e-03 8.220330e-03 17 3647444 3647522 79 + 2.096 1.967 -0.432
ENSG00000040531 E019 0.7331471 0.0172671820 1.143951e-01 2.119534e-01 17 3647523 3647604 82 + 0.000 0.304 10.073
ENSG00000040531 E020 118.9182970 0.0002981542 1.241670e-07 1.238773e-06 17 3648847 3648931 85 + 2.145 1.993 -0.508
ENSG00000040531 E021 3.9375244 0.0039936045 6.116385e-01 7.307285e-01 17 3650174 3650519 346 + 0.714 0.658 -0.234
ENSG00000040531 E022 159.5650091 0.0010997810 4.467102e-05 2.546885e-04 17 3654998 3655101 104 + 2.244 2.138 -0.356
ENSG00000040531 E023 168.3749418 0.0043624080 1.951541e-03 7.076128e-03 17 3655221 3655326 106 + 2.264 2.162 -0.338
ENSG00000040531 E024 99.2207774 0.0031651421 2.072601e-03 7.448930e-03 17 3655327 3655352 26 + 2.041 1.929 -0.378
ENSG00000040531 E025 161.9322747 0.0002731143 3.074798e-04 1.409927e-03 17 3656487 3656586 100 + 2.235 2.154 -0.270
ENSG00000040531 E026 183.8117036 0.0002195318 2.676888e-02 6.550801e-02 17 3656676 3656795 120 + 2.265 2.228 -0.123
ENSG00000040531 E027 187.6636518 0.0032927215 3.130654e-01 4.555959e-01 17 3658005 3658175 171 + 2.208 2.270 0.210
ENSG00000040531 E028 204.8013754 0.0027287721 2.243979e-01 3.556884e-01 17 3659858 3659975 118 + 2.240 2.308 0.226
ENSG00000040531 E029 236.8664021 0.0002568498 1.660528e-01 2.830707e-01 17 3660236 3660350 115 + 2.310 2.367 0.190
ENSG00000040531 E030 277.7585298 0.0001668398 9.603767e-04 3.823163e-03 17 3660351 3660616 266 + 2.349 2.447 0.325
ENSG00000040531 E031 785.4277870 0.0070368942 1.782072e-04 8.702542e-04 17 3660617 3663103 2487 + 2.758 2.917 0.530