ENSG00000040199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000564884 ENSG00000040199 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP2 protein_coding nonsense_mediated_decay 5.547528 3.156993 8.869283 0.2217489 0.2684099 1.487329 0.1123847 0.30729390 0.03477697 0.10782718 0.03477697 -2.824991 0.03117917 0.09386667 0.003733333 -0.09013333 9.180672e-04 3.562947e-05 TRUE TRUE
ENST00000568004 ENSG00000040199 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP2 protein_coding nonsense_mediated_decay 5.547528 3.156993 8.869283 0.2217489 0.2684099 1.487329 0.3566688 0.12236817 0.51023938 0.04343805 0.12196448 1.974619 0.06220000 0.03796667 0.057066667 0.01910000 7.662381e-01 3.562947e-05 TRUE TRUE
ENST00000568954 ENSG00000040199 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP2 protein_coding protein_coding 5.547528 3.156993 8.869283 0.2217489 0.2684099 1.487329 4.0205292 2.65825049 6.37391891 0.09710120 0.18760568 1.258548 0.74786250 0.84653333 0.718800000 -0.12773333 3.199222e-02 3.562947e-05 FALSE TRUE
MSTRG.12960.6 ENSG00000040199 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLPP2 protein_coding   5.547528 3.156993 8.869283 0.2217489 0.2684099 1.487329 0.6533404 0.04362673 1.30256147 0.02484888 0.23994901 4.613289 0.09777500 0.01286667 0.145533333 0.13266667 3.562947e-05 3.562947e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000040199 E001 0.5932745 0.0250980918 3.575011e-01 5.018972e-01 16 71637835 71637835 1 - 0.143 0.319 1.479
ENSG00000040199 E002 12.6777371 0.0498090707 3.512594e-03 1.176268e-02 16 71637836 71638383 548 - 0.925 1.367 1.587
ENSG00000040199 E003 10.5067190 0.0489504156 2.959697e-03 1.014356e-02 16 71640522 71641040 519 - 0.848 1.285 1.596
ENSG00000040199 E004 0.1515154 0.0432593286 1.000000e+00   16 71644751 71644855 105 - 0.077 0.000 -8.589
ENSG00000040199 E005 0.0000000       16 71644924 71644927 4 -      
ENSG00000040199 E006 521.2784712 0.0008584280 8.612956e-54 6.606067e-51 16 71644928 71648169 3242 - 2.583 2.851 0.894
ENSG00000040199 E007 193.8107984 0.0011418966 3.772654e-06 2.761661e-05 16 71648170 71649723 1554 - 2.284 2.170 -0.380
ENSG00000040199 E008 57.4001276 0.0016799921 9.642591e-04 3.836280e-03 16 71649724 71650044 321 - 1.774 1.621 -0.518
ENSG00000040199 E009 48.2864710 0.0004446133 1.163409e-01 2.147332e-01 16 71652790 71653021 232 - 1.673 1.616 -0.196
ENSG00000040199 E010 41.2317279 0.0005007591 5.639618e-01 6.913566e-01 16 71655240 71655434 195 - 1.590 1.586 -0.015
ENSG00000040199 E011 38.9810962 0.0005918655 1.373119e-02 3.761108e-02 16 71656571 71656681 111 - 1.601 1.475 -0.432
ENSG00000040199 E012 42.2976607 0.0005268463 1.548842e-03 5.793845e-03 16 71658233 71658363 131 - 1.647 1.483 -0.563
ENSG00000040199 E013 41.8906641 0.0005417816 1.579021e-02 4.226347e-02 16 71658653 71658815 163 - 1.630 1.513 -0.400
ENSG00000040199 E014 35.0134712 0.0007764908 2.714817e-01 4.102500e-01 16 71663899 71664099 201 - 1.533 1.490 -0.144
ENSG00000040199 E015 34.1245171 0.0006464958 1.997647e-01 3.259421e-01 16 71667178 71667333 156 - 1.523 1.467 -0.191
ENSG00000040199 E016 33.5731395 0.0020345623 7.763498e-02 1.556677e-01 16 71669275 71669370 96 - 1.528 1.433 -0.324
ENSG00000040199 E017 29.0094018 0.0007636561 4.893225e-02 1.072586e-01 16 71672262 71672322 61 - 1.471 1.357 -0.394
ENSG00000040199 E018 36.1474533 0.0006189487 4.047627e-03 1.327473e-02 16 71676447 71676587 141 - 1.577 1.416 -0.555
ENSG00000040199 E019 25.4208500 0.0007986325 9.345448e-03 2.714566e-02 16 71676588 71676649 62 - 1.429 1.252 -0.617
ENSG00000040199 E020 0.4470576 0.0215309917 8.279145e-01 8.918236e-01 16 71676650 71678754 2105 - 0.143 0.189 0.482
ENSG00000040199 E021 36.4873177 0.0006553150 5.305186e-03 1.676148e-02 16 71678755 71678922 168 - 1.579 1.424 -0.532
ENSG00000040199 E022 30.1370821 0.0007272167 8.306201e-03 2.456002e-02 16 71678923 71678985 63 - 1.499 1.336 -0.563
ENSG00000040199 E023 39.5345714 0.0005842820 6.333376e-05 3.477190e-04 16 71679389 71679535 147 - 1.630 1.397 -0.798
ENSG00000040199 E024 38.2484093 0.0005771141 2.931268e-06 2.198242e-05 16 71681751 71681905 155 - 1.626 1.336 -0.996
ENSG00000040199 E025 26.6394433 0.0006900817 5.513498e-04 2.351903e-03 16 71684476 71684601 126 - 1.469 1.225 -0.849
ENSG00000040199 E026 0.0000000       16 71684602 71684657 56 -      
ENSG00000040199 E027 34.2034337 0.0049602150 4.868993e-04 2.110068e-03 16 71690519 71690709 191 - 1.575 1.335 -0.827
ENSG00000040199 E028 27.3272589 0.0007562140 1.012910e-01 1.924355e-01 16 71702598 71702731 134 - 1.448 1.357 -0.314
ENSG00000040199 E029 39.0594831 0.0169938925 1.437191e-02 3.907288e-02 16 71714512 71714801 290 - 1.618 1.430 -0.645
ENSG00000040199 E030 0.2924217 0.0272836782 6.258354e-01   16 71714802 71715529 728 - 0.143 0.000 -9.740
ENSG00000040199 E031 11.2929270 0.0018320844 1.214159e-04 6.203983e-04 16 71723769 71723908 140 - 1.147 0.682 -1.775
ENSG00000040199 E032 0.0000000       16 71724329 71724701 373 -